1,5-Anhydroglucitol GlycoMark
1,5 AG
Description
"1,5-Anhydroglucitol" test measures a glucose-like molecule to assess short-term blood sugar fluctuations over the past one to two weeks. Doctors use it to evaluate glycemic variability in people with diabetes, especially when standard tests miss spikes. Low levels may indicate frequent post-meal glucose surges. This test helps tailor diabetes management by identifying patterns that affect overall control. Results guide treatment adjustments and support more precise monitoring of blood sugar stability over time.
Test Category
Sugars
Procedure
Invasive
Sample Type
Blood – Serum
Units
Micrograms Per Milliliter | Micromoles Per Liter
Procedure Category
Blood Draw
Test Group
Complete Blood Sugar Group
Test Group Description
Complete Blood Sugar Group: This expanded group includes a more comprehensive set of tests, offering a thorough evaluation of diverse facets of blood sugar levels for a more detailed understanding of metabolic health.
Optimal Range
For All Individuals:
Conventional Unit: 24.00–36.60 µg/mL
SI Unit: Not Frequently Used
Normal Range
For All Individuals:
Conventional Unit: 7.30–36.60 µg/mL
SI Unit: Not Frequently Used
Results That Differ From The Norm (Direct and Indirect Causes)
Decreased levels may indicate:
Cardiovascular disease (heart and blood vessel condition)
Kidney disease (renal impairment)
Medication (such as diabetics)
Microvascular disease (small blood vessel damage)
Type 2 diabetes (metabolic disorder)
Key Reasons For Testing
Management of Diabetes: Provides insights into short-term blood sugar control.
Postprandial Glucose Monitoring: Tracks blood sugar spikes after meals over 1–2 weeks.
Detection of Glycemic Variability: Identifies fluctuations in blood sugar levels to assess complication risk.
Identifying Glycemic Excursions: Spots high blood sugar episodes missed by HbA1c tests.
Assessment of Treatment Efficacy: Evaluates how well diabetes treatments are controlling blood sugar.
Health Status Conditions It May Be Used To Assess
Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.
Some Prominent Medical Labs That May Offer This Test
Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.
References
Important Note
Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.
Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.
Disclaimer
This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.
Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.
[1] McGill JB, Cole TG, Nowatzke W, et al. Circulating 1,5-anhydroglucitol levels in adult patients with diabetes reflect longitudinal changes of glycemia: a U.S. trial of the GlycoMark assay. Diabetes Care. 2004;27(8):1859-1865.
[2] Buse JB, Freeman JL, Edelman SV, et al. Serum 1,5-anhydroglucitol (GlycoMark): a short-term glycemic marker. Diabetes Technol Ther. 2003;5(3):355-363.
[3] Yamanouchi T, Minoda S, Yabuuchi M, et al. Plasma 1,5-anhydro-D-glucitol as a new clinical marker of glycemic control in NIDDM patients. Lancet. 1989;338(8770):723-729.
[4] Dungan KM, Buse JB, Largay J, et al. 1,5-anhydroglucitol and postprandial hyperglycemia as measured by continuous glucose monitoring system in moderately controlled patients with diabetes. Diabetes Care. 2006;29(6):1214-1219.
[5] Pal A, Farmer AJ, Dudley C, et al. Evaluation of serum 1,5-anhydroglucitol levels as a clinical test to differentiate subtypes of diabetes. Diabetes Care. 2010;33(2):252-257.
[6] Herman WH, Dungan KM, Wolffenbuttel BH, et al. Racial and ethnic differences in mean plasma glucose, hemoglobin A1c, and 1,5-anhydroglucitol in over 2000 patients with type 2 diabetes. J Clin Endocrinol Metab. 2009;94(5):1689-1694.
[7] Koga M, Saito H, Mukai M, et al. Serum glycated albumin levels are influenced by smoking status, independent of plasma glucose levels. Acta Diabetol. 2010;46(3):141-144.
[8] Yamanouchi T, Shinohara T, Ogata N, et al. Common reabsorption system of 1,5-anhydro-D-glucitol, fructose, and mannose in rat renal tubule. Biochim Biophys Acta. 1996;1291(1):89-95.
[9] Dungan KM, Buse JB, Wittlin S, et al. Glycemic variability, 1,5-anhydroglucitol, and diabetes control: A closer look. Clin Diabetes. 2012;30(4):173-179.
[10] Nowatzke W, Cole TG. Stability of 1,5-anhydroglucitol in serum. Clin Chim Acta. 2006;365(1-2):337-341.