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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Adrenocorticotropic Hormone

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ACTH

Description

"Adrenocorticotropic Hormone" (ACTH) test measures ACTH levels in your blood to assess how your pituitary gland regulates cortisol production. Doctors use it when symptoms like fatigue, low blood pressure, or unexplained weight changes suggest adrenal or pituitary disorders. Elevated ACTH may indicate Addison’s disease, while low levels could suggest Cushing’s syndrome or pituitary dysfunction. Results help clarify hormone-related symptoms and guide next steps such as imaging or further testing. Regular monitoring supports accurate diagnosis and personalized endocrine care.

"Adrenocorticotropic Hormone" (ACTH) test measures ACTH levels in your blood to assess how your pituitary gland regulates cortisol production. Doctors use it when symptoms like fatigue, low blood pressure, or unexplained weight changes suggest adrenal or pituitary disorders. Elevated ACTH may indicate Addison’s disease, while low levels could suggest Cushing’s syndrome or pituitary dysfunction. Results help clarify hormone-related symptoms and guide next steps such as imaging or further testing. Regular monitoring supports accurate diagnosis and personalized endocrine care.

Category

Hormones

Procedure

Invasive

Sample Type

Blood – Serum

Units

Picograms Per Milliliter | Picomoles Per Liter

Procedure Category

Blood Draw

Test Group

Complete Adrenal Group

Test Group Description

Complete Adrenal Group: Essential tests for a comprehensive evaluation of adrenal gland function, aiding in the diagnosis and management of adrenal disorders.

Optimal Range

For All Individuals:

  • Conventional Unit: Not Available

  • SI Unit: Not Available

Normal Range

For All Individuals:

  • Conventional Unit: 10.00–60.00 pg/mL (Morning) | < 20.00 pg/mL (Afternoon)

  • SI Unit: 2.20–13.20 pmol/L (Morning) | < 4.40 pmol/L (Afternoon)

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Addison's disease (adrenal insufficiency due to damage to the adrenal glands)

  • Cushing's syndrome (excessive cortisol production)

  • Ectopic ACTH syndrome (ACTH production by tumors outside the pituitary gland)

  • Stress-adrenogenital syndrome (adrenal gland overactivity due to stress)


Decre...

Key Reasons For Testing

  • Assessment of Adrenal Function: Evaluates adrenal gland performance by analyzing ACTH and cortisol levels.

  • Diagnosis of Adrenal Insufficiency: Identifies adrenal dysfunction by measuring ACTH and cortisol.

  • Cushing's Syndrome Evaluation: Detects abnormal ACTH levels to diagnose Cushing’s syndrome.

  • Adrenal Tumor Localization: Helps locate ACTH-producing tumors in ACTH-dependent Cushing’s syndrome.

  • Pituitary Function Assessment: Evaluates how well the pituitary gland regulates ACTH production.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Aron DC, Findling JW, Tyrrell JB. Hypothalamus and pituitary. In: Gardner DG, Shoback D, eds. Greenspan’s Basic and Clinical Endocrinology. 9th ed. New York, NY: McGraw-Hill; 2011:95-156.
[2] Nieman LK, Biller BM, Findling JW, et al. The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2008;93(5):1526-1540.
[3] Raff H, Findling JW. A physiologic approach to diagnosis of the Cushing syndrome. Ann Intern Med.2003;138(12):980-991.
[4] El-Farhan N, Pickett A, Ducroq DH, et al. Method-specific serum cortisol responses to the adrenocorticotrophin test: comparison of gas chromatography–mass spectrometry and five automated immunoassays. Clin Endocrinol (Oxf).2013;78(5):673-680.
[5] Lamberts SW, de Jong FH, de Moor P, et al. Plasma ACTH and cortisol in Cushing's disease. Clin Endocrinol (Oxf).1978;9(3):241-247.
[6] Chrousos GP, Gold PW. The concepts of stress and stress system disorders: overview of physical and behavioral homeostasis. JAMA. 1992;267(9):1244-1252.
[7] Orth DN, Kovacs WJ. The adrenal cortex. In: Wilson JD, Foster DW, Kronenberg HM, et al., eds. Williams Textbook of Endocrinology. 9th ed. Philadelphia, PA: WB Saunders; 1998:517-664.
[8] Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and treatment of primary adrenal insufficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(2):364-389.
[9] Charmandari E, Nicolaides NC, Chrousos GP. Adrenal insufficiency. Lancet. 2014;383(9935):2152-2167.
[10] Pecori Giraldi F, Cavagnini F. Recent advances in diagnosis and therapy of Cushing's syndrome. Endocrinol Metab Clin North Am. 2002;31(3):791-808.
[11] Newell-Price J, Bertagna X, Grossman AB, Nieman LK. Cushing's syndrome. Lancet. 2006;367(9522):1605-1617.
[12] Clayton RN. Differential diagnosis of Cushing's syndrome. Endocrinol Metab Clin North Am. 1994;23(3):529-548.

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