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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Anion Gap

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AG

Description

"Anion Gap" test evaluates the acid-base balance in your blood by calculating differences between electrolytes such as sodium, chloride, and bicarbonate. Often included in routine blood panels, this measurement helps detect metabolic conditions like kidney disease, dehydration, or metabolic acidosis. While not diagnostic on its own, the results guide further evaluation and inform treatment decisions. Regular anion gap checks are particularly beneficial when managing chronic illnesses that affect electrolyte stability or your body's acid-base balance.

"Anion Gap" test evaluates the acid-base balance in your blood by calculating differences between electrolytes such as sodium, chloride, and bicarbonate. Often included in routine blood panels, this measurement helps detect metabolic conditions like kidney disease, dehydration, or metabolic acidosis. While not diagnostic on its own, the results guide further evaluation and inform treatment decisions. Regular anion gap checks are particularly beneficial when managing chronic illnesses that affect electrolyte stability or your body's acid-base balance.

Test Category

Electrolytes

Procedure

Invasive

Sample Type

Blood – Serum

Units

Millimoles Per Liter

Procedure Category

Blood Draw

Test Group

Acid-Base Group

Test Group Description

Acid-Based: Tests in this group focus on evaluating the body's acid-base balance, providing essential insights into pH levels and bicarbonate measurements.

Optimal Range

For All Individuals:

  • Conventional Unit: 7.00–12.00 mmol/L

  • SI Unit: 7.00–12.00 mmol/L

Normal Range

For All Individuals:

  • Conventional Unit: 6.00–16.00 mmol/L

  • SI Unit: 6.00–16.00 mmol/L

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Alcoholic acidosis (Resulting from alcohol consumption)

  • Diabetic ketoacidosis (Life-threatening complication of diabetes)

  • Hypoaldosteronism (Decreased production of aldosterone hormone)

  • Increased gastrointestinal losses of bicarbonate

  • Lactic acidosis (Build-up of lactic acid in the bloodstream)

  • ...

Key Reasons For Testing

  • Acid-Base Status Assessment: Evaluates the balance of acids and bases in the blood.

  • Diagnosis of Metabolic Acidosis: Identifies conditions like ketoacidosis, lactic acidosis, or kidney failure.

  • Evaluation of Electrolyte Imbalance: Detects abnormalities in electrolytes like chloride or lactate.

  • Toxin Ingestion Detection: Identifies harmful substances like methanol or ethylene glycol that cause metabolic acidosis.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Lambert DC, Abramowitz MK. Obesity, anion accumulation, and anion gap metabolic acidosis: a cohort study. Kidney360. 2021;2(11):1706-1715.
[2] Winter SD, Pearson JR, Gabow PA, Schultz AL, Lepoff RB. The fall of the serum anion gap. Arch Intern Med.1990;150(2):311-313.
[3] Emmett M, Narins RG. Clinical use of the anion gap. Medicine (Baltimore). 1977;56(1):38-54.
[4] Figge J, Mydosh T, Fencl V. Serum proteins and acid-base equilibria: a follow-up. J Lab Clin Med. 1992;120(5):713-719.
[5] Kraut JA, Madias NE. Serum anion gap: its uses and limitations in clinical medicine. Clin J Am Soc Nephrol.2007;2(1):162-174.
[6] Gabow PA, Kaehny WD, Fennessey PV. Diagnostic importance of an increased serum anion gap. N Engl J Med.1980;303(15):854-858.
[7] Figge J, Jabor A, Kazda A, Fencl V. Anion gap and hypoalbuminemia. Crit Care Med. 1998;26(11):1807-1810.
[8] Kraut JA, Madias NE. Metabolic acidosis: pathophysiology, diagnosis, and management. Nat Rev Nephrol.2010;6(5):274-285.
[9] Weiner ID, Wingo CS. Hypokalemia - consequences, causes, and correction. J Am Soc Nephrol. 1997;8(7):1179-1188.
[10] Berend K, de Vries AP, Gans RO. Physiological approach to assessment of acid-base disturbances. N Engl J Med.2014;371(15):1434-1445.
[11] Kraut JA, Madias NE. Lactic acidosis. N Engl J Med. 2014;371(24):2309-2319.

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