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Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Anti-Cyclic Citrullinated Peptide Antibody

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ACCP

Description

"Anti-Cyclic Citrullinated Peptide Antibody" test detects anti-CCP antibodies linked to rheumatoid arthritis. These antibodies can mistakenly target joint tissue, causing inflammation, pain, and stiffness. Doctors use this test to confirm RA in patients with joint symptoms and guide early treatment. High anti-CCP levels signal increased risk of joint damage. Results help shape personalized care plans and medication strategies. Ongoing testing may also track disease progression and support timely adjustments to improve joint function and quality of life.

"Anti-Cyclic Citrullinated Peptide Antibody" test detects anti-CCP antibodies linked to rheumatoid arthritis. These antibodies can mistakenly target joint tissue, causing inflammation, pain, and stiffness. Doctors use this test to confirm RA in patients with joint symptoms and guide early treatment. High anti-CCP levels signal increased risk of joint damage. Results help shape personalized care plans and medication strategies. Ongoing testing may also track disease progression and support timely adjustments to improve joint function and quality of life.

Test Category

Autoantibodies

Procedure

Invasive

Sample Type

Blood – Serum

Units

Units Per Milliliter

Procedure Category

Blood Draw

Test Group

Chronic Illness Group, Autoimmune Condition Group

Test Group Description

Chronic Illness Group: This group encompasses a range of tests specifically tailored to assess markers associated with chronic health conditions, providing comprehensive insights into the management and monitoring of chronic illnesses. Autoimmune Condition Group: Tests within this group focus on markers associated with autoimmune diseases, providing insights into the body's immune response against its own tissues.

Optimal Range

For All Individuals:

  • Conventional Unit: < 20.00 U/mL

  • SI Unit: < 20.00 U/mL

Normal Range

For All Individuals:

  • Conventional Unit: < 20.00 U/mL

  • SI Unit: < 20.00 U/mL

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Rheumatoid Arthritis (Autoimmune disease causing inflammation and pain in the joints)

Key Reasons For Testing

  • Early Detection of Rheumatoid Arthritis (RA): Identifies antibodies that detect RA before symptoms appear.

  • Prognostic Indicator: Predicts disease severity and progression in RA.

  • Differential Diagnosis: Distinguishes RA from other types of arthritis.

  • Predictive Marker for Joint Damage: Assesses the likelihood of joint damage severity.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Nienhuis RL, Mandema E. A new serum factor in patients with rheumatoid arthritis; the antiperinuclear factor. Ann Rheum Dis. 1964;23(4):302-305.
[2] Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest.1998;101(1):273-281.
[3] van Venrooij WJ, Zendman AJ, Pruijn GJ. Autoantibodies to citrullinated antigens in (early) rheumatoid arthritis. Autoimmun Rev. 2006;6(1):37-41.
[4] Rantapää-Dahlqvist S, de Jong BA, Berglin E, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48(10):2741-2749.
[5] Meyer O, Labarre C, Dougados M, et al. Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five-year radiographic damage. Ann Rheum Dis. 2003;62(2):120-126.
[6] van Gaalen FA, Linn-Rasker SP, van Venrooij WJ, et al. Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis. Arthritis Rheum. 2004;50(3):709-715.
[7] Innala L, Kokkonen H, Eriksson C, et al. Antibodies to citrullinated peptides before onset of rheumatoid arthritis. Arthritis Rheum. 2008;58(6):1567-1571.
[8] Kastbom A, Strandberg G, Lindroos A, Skogh T. Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project). Ann Rheum Dis. 2004;63(9):1085-1089.
[9] Nishimura K, Sugiyama D, Kogata Y, et al. Meta-analysis: diagnostic accuracy of anti–cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med. 2007;146(11):797-808.
[10] Visser H, le Cessie S, Vos K, Breedveld FC, Hazes JM. How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis. Arthritis Rheum. 2002;46(2):357-365.
[11] Schett G, Redlich K, Smolen JS. The role of citrullinated proteins in the immunopathogenesis of rheumatoid arthritis. Nat Rev Immunol. 2008;8(6):383-389.

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