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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Anti-Thyroid Peroxidase Antibodies

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ANTI-TPO

Description

"Anti-Thyroid Peroxidase Antibodies" (anti-TPO) test detects antibodies that target thyroid peroxidase, an enzyme essential for hormone production. Doctors may recommend this test when unexplained fatigue, weight gain, or cold sensitivity becomes a concern. Elevated anti-TPO levels may indicate autoimmune thyroid conditions such as Hashimoto’s thyroiditis or Graves’ disease. The results help clarify the cause of thyroid dysfunction and guide treatment decisions. Ongoing testing supports early detection, helps monitor disease progression, and aids in long-term thyroid health management.

"Anti-Thyroid Peroxidase Antibodies" (anti-TPO) test detects antibodies that target thyroid peroxidase, an enzyme essential for hormone production. Doctors may recommend this test when unexplained fatigue, weight gain, or cold sensitivity becomes a concern. Elevated anti-TPO levels may indicate autoimmune thyroid conditions such as Hashimoto’s thyroiditis or Graves’ disease. The results help clarify the cause of thyroid dysfunction and guide treatment decisions. Ongoing testing supports early detection, helps monitor disease progression, and aids in long-term thyroid health management.

Category

Autoantibodies

Procedure

Invasive

Sample Type

Blood – Serum

Units

International Units Per Milliliter

Procedure Category

Blood Draw

Test Group

Basic Thyroid Group, Complete Thyroid Group

Test Group Description

Basic Thyroid Group: This group includes essential tests for evaluating thyroid function and detecting common thyroid disorders. Complete Thyroid Group: A comprehensive array of tests for a thorough evaluation of thyroid function, providing detailed insights into thyroid health and associated conditions.

Optimal Range

For All Individuals:

  • Conventional Unit: < 0.20 IU/mL

  • SI Unit: < 0.20 IU/mL

Normal Range

For All Individuals:

  • Conventional Unit: 0.00–34.00 IU/mL

  • SI Unit: 0.00–34.00 IU/mL

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Chronic lymphocytic thyroiditis (Autoimmune inflammation of the thyroid gland)

  • Graves' disease (Autoimmune hyperthyroidism)

  • Hashimoto's disease (Autoimmune hypothyroidism)

  • Postpartum thyroiditis (Thyroid inflammation after childbirth)

  • Subclinical hypothyroidism (Mild thyroid underactivity without noticeable symptoms)

Key Reasons For Testing

  • Autoimmune Thyroid Disease Diagnosis: Detects antibodies to identify conditions like Hashimoto's or Graves' disease.

  • Differential Diagnosis: Distinguishes autoimmune thyroid disorders from other causes of thyroid dysfunction.

  • Prognostic Indicator: Predicts the progression of thyroid issues, including hypothyroidism or hyperthyroidism.

  • Prediction of Postpartum Thyroiditis: Identifies pregnant individuals at risk for thyroid issues after childbirth.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Hage MP, Azar ST. The link between thyroid function and depression. J Thyroid Res. 2012;2012:590648.
[2] McLachlan SM, Rapoport B. Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity. Endocr Rev. 2014;35(1):59-105.
[3] Burek CL, Rose NR. Autoimmune thyroiditis and ROS-induced thyroid cell damage. Clin Exp Immunol.2008;153(1):142-146.
[4] Effraimidis G, Wiersinga WM. Mechanisms in endocrinology: autoimmune thyroid disease in the elderly. Eur J Endocrinol. 2014;171(3):R13-R20.
[5] Vanderpump MP, Tunbridge WM, French JM, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf). 1995;43(1):55-68.
[6] Weetman AP. Chronic autoimmune thyroiditis (Hashimoto's disease). Horm Metab Res. 1997;29(10):397-401.
[7] Antonelli A, Ferrari SM, Corrado A, Di Domenicantonio A, Fallahi P. Autoimmune thyroid disorders. Autoimmun Rev. 2015;14(2):174-180.
[8] Prummel MF, Strieder T, Wiersinga WM. The environment and autoimmune thyroid diseases. Eur J Endocrinol.2004;150(5):605-618.
[9] Das G, Ojha P, von Schoultz B, Lambe M, Albertsson-Wikland K, et al. High prevalence of goiter in healthy girls from iodine-replete area: associations with thyroid antibodies and thyroglobulin. Eur J Clin Nutr. 2011;65(7):828-834.
[10] Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab.2002;87(2):489-499.
[11] Spencer CA, LoPresti JS, Patel A, et al. Detection of antibodies against thyroglobulin and thyroid peroxidase in serum: effects on free thyroid hormone measurement. J Clin Endocrinol Metab. 1996;81(2):667-674.
[12] Amino N, Miyai K. Thyroid autoantibodies and pregnancy: significance of testing and diagnostic challenges. Best Pract Res Clin Endocrinol Metab. 2007;21(2):259-270.

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