Bilirubin Indirect
BR I
Description
"Bilirubin Indirect" test measures the level of indirect (unconjugated) bilirubin in your blood, often used to detect hemolytic anemia or liver conditions affecting bilirubin processing. High levels may result from increased red blood cell breakdown or impaired liver metabolism. This test is helpful when patients present with unexplained jaundice, fatigue, or anemia. The results support diagnosis and guide decisions on treatment or further testing. Monitoring indirect bilirubin helps detect issues related to red blood cell turnover or early liver dysfunction.
Test Category
Breakdown Byproducts, Waste Metabolites
Procedure
Invasive
Sample Type
Blood – Serum
Units
Milligrams Per Deciliter | Micromoles Per Liter
Procedure Category
Blood Draw
Test Group
Basic Liver Group, Complete Liver Group, Gallbladder Group
Test Group Description
Basic Liver Group: This set of tests is fundamental for evaluating liver function and detecting common liver disorders. Complete Liver Group: A thorough array of tests aimed at assessing liver function, providing detailed insights into hepatic health and related conditions. Gallbladder Group: This group of tests evaluates gallbladder function and health, providing insights into digestive well-being and related conditions.
Optimal Range
For All Individuals:
Conventional Unit: 0.20–0.80 mg/dL
SI Unit: 3.42–13.68 µmol/L
Normal Range
For All Individuals:
Conventional Unit: 0.20–1.00 mg/dL
SI Unit: 3.42–17.10 µmol/L
Results That Differ From The Norm (Direct and Indirect Causes)
Increased levels may indicate:
Gilbert syndrome (a genetic liver disorder)
Hepatitis (inflammation of the liver)
Hemolytic anemia (accelerated breakdown of red blood cells)
Hemolytic jaundice (jaundice due to excessive breakdown of red blood cells)
Injury-induced skin bleeding
Pernicious anemia (a type of vitamin B12 deficiency anemia)
Pulmonary embolism (blockage of a pulmonary artery)
Sepsis (severe bloodstream infection)
Sickle cell anemia (a genetic blood disorder)
Key Reasons For Testing
Assessment of Hemolysis: Detects elevated levels caused by rapid red blood cell breakdown, aiding in conditions like hemolytic anemia.
Evaluation of Liver Function: Assesses the liver's ability to process indirect bilirubin, highlighting potential dysfunction.
Assessment of Neonatal Jaundice: Identifies elevated levels in newborns to guide treatments like phototherapy.
Diagnosis of Gilbert Syndrome: Detects high levels associated with this benign genetic condition.
Health Status Conditions It May Be Used To Assess
Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.
Some Prominent Medical Labs That May Offer This Test
Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.
References
Important Note
Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.
Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.
Disclaimer
This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.
Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.
[1] Ostrow JD, Pascolo L, Shapiro SM, Tiribelli C. New concepts in bilirubin neurotoxicity and the role of bilirubin in health and disease. Trends Mol Med. 2004;10(2):65-70.
[2] Berk PD, Howe RB, Bloomer JR, Berlin NI. Studies of bilirubin kinetics in normal adults. J Clin Invest.1969;48(11):2176-2190.
[3] Schmid R, Hammaker L. The congenital dyserythropoietic anemias. J Clin Invest. 1963;42(5):736-745.
[4] Felsher BF, Rickards EP. Bilirubin metabolism in the newborn infant. Am J Dis Child. 1962;103(6):667-679.
[5] Jansen PL, Sturm E. Genetic cholestasis and hepatocellular transport. Clin Liver Dis. 2006;10(2):209-223.
[6] Shapiro SM. Bilirubin toxicity in the developing nervous system. Pediatrics. 2003;112(6):176-180.
[7] Watchko JF, Tiribelli C. Bilirubin-induced neurologic damage—mechanisms and management approaches. N Engl J Med. 2013;369(21):2021-2030.
[8] Maisels MJ. Managing the jaundiced newborn: a persistent challenge. Clin Perinatol. 2015;42(2):429-438.
[9] Wennberg RP, Ahlfors CE, Bhutani VK, Johnson LH, Shapiro SM. Toward understanding kernicterus: a challenge to improve the management of jaundiced newborns. Pediatrics. 2006;117(2):474-485.
[10] Vitek L, Ostrow JD. Bilirubin chemistry and metabolism; harmful and protective aspects. Curr Pharm Des.2009;15(25):2869-2873.
[11] McDonagh AF. Is bilirubin good for you? Clin Perinatol. 1990;17(2):359-369.