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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Blood Urea Nitrogen-to-Creatinine Ratio

different-type-serum-containing-blood-samples

BUN / CR

Description

"Blood Urea Nitrogen-to-Creatinine Ratio" test compares the concentration of urea nitrogen and creatinine in your blood to assess kidney health and hydration status. It’s especially helpful in evaluating whether kidney changes stem from fluid loss, low blood flow, or broader systemic issues. A high ratio may point to dehydration or heart failure, while a low ratio could indicate liver dysfunction. This ratio supports personalized care adjustments and helps guide long-term kidney monitoring and treatment planning.

"Blood Urea Nitrogen-to-Creatinine Ratio" test compares the concentration of urea nitrogen and creatinine in your blood to assess kidney health and hydration status. It’s especially helpful in evaluating whether kidney changes stem from fluid loss, low blood flow, or broader systemic issues. A high ratio may point to dehydration or heart failure, while a low ratio could indicate liver dysfunction. This ratio supports personalized care adjustments and helps guide long-term kidney monitoring and treatment planning.

Category

Waste Metabolites

Procedure

Invasive

Sample Type

Blood – Serum

Units

Ratio

Procedure Category

Blood Draw

Test Group

Complete Metabolic Group, Basic Kidney Group, Complete Kidney Group

Test Group Description

Basic Kidney Group: This group includes tests essential for assessing kidney function and detecting common kidney disorders. Complete Kidney Group: Comprehensive tests provide a thorough assessment of kidney function, yielding detailed insights into renal health and associated conditions. Complete Metabolic Group: A comprehensive suite of tests designed to evaluate metabolic function, offering detailed insights into various aspects of metabolism and associated health conditions.

Optimal Range

For All Individuals:

  • Conventional Unit: 10.0–16.0 R

  • SI Unit: Not Applicable

Normal Range

For All Individuals:

  • Conventional Unit: 10.0–20.0 R

  • SI Unit: Not Applicable

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Dehydration (loss of body water)

  • Heart failure (inability of the heart to pump blood effectively)

  • High protein intake

  • Hyperthyroidism (overactive thyroid gland)

  • Intestinal bleeding

  • Kidney diseases

  • Nephrotoxic substance use (substances harmful to the kidneys)

  • Urinary tract obstruction


Decreased levels may indicate:


  • Kidney damage

  • Liver disease

  • Malnutrition

  • Particular prescription uses

  • Rhabdomyolysis (rapid breakdown of muscle tissue)

  • Sickle cell anemia (genetic blood disorder)

Key Reasons For Testing

  • Kidney Function Assessment: Evaluates kidney health by comparing BUN and creatinine levels.

  • Dehydration Evaluation: A high ratio indicates fluid imbalance, aiding in diagnosis and treatment.

  • GI Bleeding Screening: Suggests gastrointestinal bleeding when the ratio is elevated, guiding further investigation.

  • Renal Perfusion Monitoring: Assesses kidney blood flow in critically ill patients to support clinical decisions.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Gounden V, Bhatt H, Jialal I. Renal Function Tests. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
[2] Hosten AO. BUN and Creatinine. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990.
[3] Moran SM, Myers BD. Course of acute renal failure studied by a model of creatinine kinetics. Kidney Int.1985;27(6):928-937.
[4] Gowda S, Desai PB, Kulkarni SS, Hull VV, Math AA, Vernekar SN. Markers of renal function tests. N Am J Med Sci.2010;2(4):170-173.
[5] Johnson DW, Craven AM, Isbel NM. Modification of diet in renal disease (MDRD) study equation to estimate glomerular filtration rate. Nephrology. 2005;10(5):497-504.
[6] Macedo E, Mehta RL. Assessing the response to acute therapies in acute kidney injury: more than just recovery of renal function. Nephron Clin Pract. 2009;113(3).
[7] Thomas L, Huber AR. Renal function--estimation of glomerular filtration rate. Clin Chem Lab Med.2006;44(11):1295-1302.
[8] Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16(11):3365-3370.
[9] Waikar SS, Bonventre JV. Biomarkers for the diagnosis of acute kidney injury. Nephron Clin Pract.2008;109(4):c192-c197.
[10] McGee S, Boyko EJ. BUN-to-creatinine ratio: a guide to interpretation in acute illness. Am J Med Sci.2000;319(4):235-239.
[11] Prowle JR, Bellomo R. Sepsis-associated acute kidney injury: macrohemodynamic and microhemodynamic alterations in the renal circulation. Semin Nephrol. 2015;35(1):64-74.
[12] Chua HR, Bailey M, Bellomo R. BUN: Creatinine ratio and mortality in critically ill patients with acute kidney injury from sepsis: A retrospective cohort study. Nephrology. 2012;17(2):91-96.
[13] Kimmel PL, Phillips TM. Immune-mediated renal disease. JAMA. 1996;275(20):1617-1626.

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