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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Ceruloplasmin

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CP

Description

"Ceruloplasmin" test measures a copper-carrying protein made by the liver and is used to evaluate copper metabolism. It helps detect Wilson’s disease, liver dysfunction, or malnutrition. Low results may indicate copper buildup, while higher levels can relate to inflammation or rheumatoid issues. Doctors may order this test when symptoms like tremors, jaundice, or fatigue appear. Based on findings, care may include medications, dietary changes, or further testing. Monitoring ceruloplasmin supports early detection and management of copper-related conditions.

"Ceruloplasmin" test measures a copper-carrying protein made by the liver and is used to evaluate copper metabolism. It helps detect Wilson’s disease, liver dysfunction, or malnutrition. Low results may indicate copper buildup, while higher levels can relate to inflammation or rheumatoid issues. Doctors may order this test when symptoms like tremors, jaundice, or fatigue appear. Based on findings, care may include medications, dietary changes, or further testing. Monitoring ceruloplasmin supports early detection and management of copper-related conditions.

Category

Proteins

Procedure

Invasive

Sample Type

Blood – Serum

Units

Milligrams Per Deciliter | Grams Per Liter

Procedure Category

Blood Draw

Test Group

Complete Metabolic Group

Test Group Description

Complete Metabolic Group: A comprehensive suite of tests designed to evaluate metabolic function, offering detailed insights into various aspects of metabolism and associated health conditions.

Optimal Range

For All Individuals:

  • Conventional Unit: 20.00–35.00 mg/dL

  • SI Unit: 0.20–0.35 g/L

Normal Range

For All Individuals:

  • Conventional Unit: 18.00–45.00 mg/dL

  • SI Unit: 0.18–0.45 g/L

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Copper toxicity

  • Wilson's disease (genetic disorder causing copper buildup in the body)


Decreased levels may indicate:


  • Copper deficiency

  • Menkes' disease (genetic disorder leading to impaired copper absorption)

Key Reasons For Testing

  • Assessment of Wilson’s Disease: Helps identify this genetic disorder where copper builds up in the body due to improper processing.

  • Evaluation of Copper Metabolism: Assesses how well the body processes copper by measuring ceruloplasmin levels.

  • Screening for Copper Deficiency: Detects low levels of ceruloplasmin, indicating insufficient copper intake or absorption.

  • Identification of Liver Disease: Evaluates liver function and severity of conditions like cirrhosis or hepatitis.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Harris ED. Basic and clinical aspects of copper in humans. Crit Rev Clin Lab Sci. 2003;40(5):547-586.
[2] Linder MC. Ceruloplasmin and other copper transport proteins: roles in copper homeostasis and oxidative stress. Toxicol Appl Pharmacol. 1991;110(3):212-227.
[3] Holmberg CG, Laurell CB. Investigations in serum copper. II. Isolation of the copper-containing protein, and a description of its properties. Acta Chem Scand. 1948;2(5):550-556.
[4] Walshe JM. Wilson's disease: the importance of measuring serum ceruloplasmin non-immunologically. Ann Clin Biochem. 2003;40(Pt 2):115-121.
[5] Brewer GJ. Recognition, diagnosis, and management of Wilson's disease. Proc Soc Exp Biol Med. 2000;223(1):39-46.
[6] Dzieżyc K, Karliński M, Litwin T, Chabik G, Członkowska A. Neurological and hepatic symptoms in patients with Wilson’s disease. J Neurol Sci. 2014;342(1-2):38-43.
[7] Ferenci P, Caca K, Loudianos G, et al. Diagnosis and phenotypic classification of Wilson disease. Liver Int.2003;23(3):139-142.
[8] Gitlin JD. Wilson disease. Gastroenterology. 2003;125(6):1868-1877.
[9] Roberts EA, Schilsky ML. A practice guideline on Wilson disease. Hepatology. 2008;47(6):2089-2111.
[10] Gaggini M, Carli F, Pingitore A, et al. Altered amino acid concentrations in nonalcoholic fatty liver disease and their associations with clinical features. Am J Clin Nutr. 2018;108(2):261-270.
[11] Hellman NE, Gitlin JD. Ceruloplasmin metabolism and function. Annu Rev Nutr. 2002;22:439-458.
[12] Zatta P, Frank P. Copper deficiency and neurological disorders in humans: possible implications for ceruloplasmin dysfunction. Neurotoxicology. 2007;28(1):93-100.

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