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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Creatinine Clearance

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CRCL

Description

"Creatinine Clearance" test evaluates how efficiently your kidneys clear creatinine from your bloodstream by combining blood and 24-hour urine measurements. It’s used to assess kidney performance and track conditions like diabetes or high blood pressure. Abnormal clearance rates may signal impaired filtration, dehydration, or early-stage kidney disease. Doctors rely on this test to uncover subtle changes in kidney health and refine care strategies. Regular testing provides a detailed picture of kidney function over time.

"Creatinine Clearance" test evaluates how efficiently your kidneys clear creatinine from your bloodstream by combining blood and 24-hour urine measurements. It’s used to assess kidney performance and track conditions like diabetes or high blood pressure. Abnormal clearance rates may signal impaired filtration, dehydration, or early-stage kidney disease. Doctors rely on this test to uncover subtle changes in kidney health and refine care strategies. Regular testing provides a detailed picture of kidney function over time.

Test Category

Waste Metabolites

Procedure

Invasive

Sample Type

Blood – Serum

Units

Milliliters Per Minute

Procedure Category

Blood Draw

Test Group

Basic Kidney Group, Complete Kidney Group, Complete Prostate Group, Gastrointestinal System Group

Test Group Description

Basic Kidney Group: This group includes tests essential for assessing kidney function and detecting common kidney disorders. Complete Kidney Group: Comprehensive tests provide a thorough assessment of kidney function, yielding detailed insights into renal health and associated conditions. Complete Prostate Group: Extensive tests offering a comprehensive assessment of prostate health, providing detailed insights into prostate function and associated conditions. Gastrointestinal Health Group: This group assesses different facets of gastrointestinal function and health, providing insights into digestive well-being and related conditions.

Optimal Range

For Men:

  • Conventional Unit: 107–139 mL/min

  • SI Unit: 1.78–2.32 mL/s


For Women:

  • Conventional Unit: 87–107 mL/min

  • SI Unit: 1.45–1.78 mL/s

Normal Range

For Men:

  • Conventional Unit: 97–137 mL/min

  • SI Unit: 1.62–2.28 mL/s


For Women:

  • Conventional Unit: 88–128 mL/min

  • SI Unit: 1.47–2.13 mL/s

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Pregnancy


Decreased levels may indicate:


  • Dehydration

  • Glomerular disease (damage to the kidney's filtering units)

  • Heart failure (inability of the heart to pump blood effectively)

  • Kidney damage

  • Kidney failure

  • Lower urinary tract obstruction (blockage in the urinary tract)

  • Renal artery stenosis (narrowing of the renal arteries)

Key Reasons For Testing

  • Kidney Function: Measures how effectively the kidneys filter creatinine to assess overall function.

  • GFR Estimation: Provides a key indicator of kidney health for diagnosing and staging disease.

  • Chronic Kidney Disease (CKD): Monitors CKD progression and evaluates treatment effectiveness.

  • Acute Kidney Injury (AKI): Detects early signs of AKI to guide timely interventions.

  • Drug Dosage Adjustment: Helps tailor dosages for medications cleared through the kidneys.

  • Renal Blood Flow: Offers insights into kidney perfusion and hemodynamics.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41.
[2] Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem. 1992;38(10):1933-1953.
[3] Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med.1999;130(6):461-470.
[4] Myers GL, Miller WG, Coresh J, et al. Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem. 2006;52(1):5-18.
[5] Stevens LA, Coresh J, Greene T, Levey AS. Assessing kidney function—measured and estimated glomerular filtration rate. N Engl J Med. 2006;354(23):2473-2483.
[6] Inker LA, Schmid CH, Tighiouart H, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367(1):20-29.
[7] Granerus G, Aurell M. Reference values for 51Cr-EDTA clearance as a measure of glomerular filtration rate. Scand J Clin Lab Invest. 1981;41(6):611-616.
[8] Shemesh O, Golbetz H, Kriss JP, Myers BD. Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int. 1985;28(5):830-838.
[9] Lin J, Knight EL, Hogan ML, Singh AK. A comparison of prediction equations for estimating glomerular filtration rate in adults without kidney disease. J Am Soc Nephrol. 2003;14(10):2573-2580.
[10] Pierratos A, Ouwendyk M, Francoeur R, et al. Nocturnal hemodialysis: three-year experience. J Am Soc Nephrol.1998;9(5):859-868.
[11] Lamb EJ, Tomson CR, Roderick PJ. Estimating kidney function in adults using formulae. Ann Clin Biochem.2005;42(Pt 5):321-345.
[12] Coresh J, Astor BC, Greene T, et al. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 2003;41(1):1-12.
[13] Waikar SS, Bonventre JV. Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol.2009;20(3):672-679.
[14] Rigalleau V, Lasseur C, Raffaitin C, et al. Estimation of renal function in patients with diabetes. Diabetes Metab.2006;32(6):618-623.
[15] Rule AD, Teo BW. GFR estimation in Japan and China: what accounts for the difference? Clin J Am Soc Nephrol.2009;4(5):832-835.

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