
Cystathionine

CYSTA
Description
"Cystathionine" test measures the amount of cystathionine in your blood, which plays a key role in converting methionine to cysteine. Doctors may recommend this test to evaluate methylation activity or investigate metabolic concerns like homocystinuria or low vitamin B6. Elevated levels may point to enzyme dysfunction or transsulfuration issues. Results help guide targeted care such as dietary changes, supplementation, or additional testing. Monitoring cystathionine levels supports methylation balance and early detection of related metabolic conditions.
Category
Metabolites
Procedure
Invasive
Sample Type
Blood – Plasma
Units
Micromoles Per Liter
Procedure Category
Blood Draw
Test Group
Methylation Group
Test Group Description
Methylation Group: Centered on evaluating methylation levels and associated parameters, this group provides insights into methylation processes and their related health implications.
Optimal Range
For All Individuals:
Conventional Unit: Not Available
SI Unit: Not Available
Normal Range
For All Individuals:
Conventional Unit: 0.00–0.30 µmol/L
SI Unit: 0.00–0.30 µmol/L
Results That Differ From The Norm (Direct and Indirect Causes)
Abnormal results may indicate:
Cystathionine Beta-Synthase Deficiency (Genetic disorder affecting enzyme function)
Homocystinuria (Elevated homocysteine levels due to genetic disorder)
Methionine Adenosyltransferase Deficiency (Rare genetic disorder affecting enzyme function)
Key Reasons For Testing
Homocysteine Metabolism: Evaluates how your body processes homocysteine, a key factor in cardiovascular and neurological health.
Screening for Homocystinuria: Detects elevated cystathionine levels linked to this rare genetic disorder.
Vitamin B6 Status: Reflects deficiencies or excesses of vitamin B6, essential for homocysteine metabolism.
Cardiovascular Risk: Identifies abnormalities in cystathionine leve...
Health Status Conditions It May Be Used To Assess
Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.
Some Prominent Medical Labs That May Offer This Test
Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.
References
Important Note
Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.
Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.
Disclaimer
This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.
Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.
[1] Finkelstein JD. Pathways and regulation of homocysteine metabolism in mammals. Semin Thromb Hemost.2000;26(3):219-225.
[2] Ueland PM, Refsum H, Stabler SP, et al. Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem. 1993;39(9):1764-1779.
[3] Stabler SP, Marcell PD, Podell ER, Allen RH. Elevation of plasma cystathionine levels in patients with cobalamin and folate deficiency. Blood. 1988;71(2):460-465.
[4] Finkelstein JD, Martin JJ. Homocysteine. Int J Biochem Cell Biol. 2000;32(4):385-389.
[5] Mudd SH, Levy HL, Kraus JP. Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. 8th ed. New York, NY: McGraw-Hill; 2001:2007-2056.
[6] Refsum H, Ueland PM, Nygård O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med. 1998;49:31-62.
[7] Smolin LA, Benevenga NJ. Accumulation of cystathionine in vitamin B6-deficient rats. J Nutr. 1977;107(2):361-371.
[8] Kraus JP, Rosenberg LE. Cystathionine beta-synthase deficiency: new mutation and polymorphism data for the transsulfuration pathway. Hum Mutat. 1991;1(2):113-123.
[9] Allen RH, Stabler SP, Savage DG, Lindenbaum J. Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J. 1993;7(14):1344-1353.
[10] Sakuta H, Suzuki T. Hyperhomocysteinemia, B vitamins, and vascular disease: a Japanese perspective. J Nutr Sci Vitaminol (Tokyo). 2005;51(3):177-181.
[11] Brenton DP. Homocystinuria and cystathionine synthase deficiency. J Inherit Metab Dis. 1990;13(4):562-570.
[12] Mudd SH, Levy HL, Skovby F. Disorders of transsulfuration: Clinical and molecular genetics. Am J Hum Genet.1995;57(3):609-620.
[13] Robinson K, Mayer EL, Miller DP, et al. Hyperhomocysteinemia and low pyridoxal phosphate: common and independent reversible risk factors for coronary artery disease. Circulation. 1995;92(10):2825-2830.
[14] Zeng Q, Li X, Ding L, et al. Elevated plasma homocysteine, cystathionine, and methylmalonic acid concentrations are associated with cognitive impairment in elderly Chinese. Mol Nutr Food Res. 2018;62(1):1700608.
[15] Stabler SP. Clinical practice. Vitamin B12 deficiency. N Engl J Med. 2013;368(2):149-160.