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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Cystatin C

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CYSC

Description

"Cystatin C" test measures the level of cystatin C, a protein filtered by the kidneys that reflects kidney function more precisely than creatinine in some cases. It’s especially useful for detecting early kidney damage or assessing cardiovascular risk in people with muscle loss or borderline kidney function. High levels suggest impaired filtration, while stable levels confirm healthy function. Doctors use this test to support individualized care and track changes in kidney or heart health over time.

"Cystatin C" test measures the level of cystatin C, a protein filtered by the kidneys that reflects kidney function more precisely than creatinine in some cases. It’s especially useful for detecting early kidney damage or assessing cardiovascular risk in people with muscle loss or borderline kidney function. High levels suggest impaired filtration, while stable levels confirm healthy function. Doctors use this test to support individualized care and track changes in kidney or heart health over time.

Test Category

Proteins

Procedure

Invasive

Sample Type

Blood – Serum

Units

Milligrams Per Liter

Procedure Category

Blood Draw

Test Group

Basic Kidney Group, Complete Kidney Group

Test Group Description

Basic Kidney Group: This group includes tests essential for assessing kidney function and detecting common kidney disorders. Complete Kidney Group: Comprehensive tests provide a thorough assessment of kidney function, yielding detailed insights into renal health and associated conditions.

Optimal Range

For All Individuals:

  • Conventional Unit: Not Available

  • SI Unit: Not Available

Normal Range

For All Individuals:

  • Conventional Unit: 0.62–1.15 mg/L

  • SI Unit: 0.62–1.15 mg/L

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Cancer

  • Chronic kidney disease

  • Diabetes (metabolic disorder affecting blood sugar levels)

  • Heart disease

  • Heart failure (inability of the heart to pump blood effectively)

  • Human immunodeficiency virus (Virus causing HIV/AIDS)

  • Hyperhomocysteinemia (elevated levels of homocysteine in the blood)

  • Hyperthyroidism (overactive thyroid gland)

  • Hypothyroidism (underactive thyroid gland)

Key Reasons For Testing

  • Kidney Function: Estimates GFR to assess renal health, especially in those with low muscle mass.

  • Early Detection of Kidney Dysfunction: Identifies mild impairment more accurately than creatinine.

  • CKD Monitoring: Tracks progression of chronic kidney disease over time.

  • Acute Kidney Injury (AKI): Detects rapid changes in kidney function for timely intervention.

  • Cardiovascular Risk: Links elevated levels to heart failure, stroke, and coronary disease.

  • Special Populations: Provides reliable GFR estimates in pediatrics, obesity, or elderly patients.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Murty MS, Sharma UK, Pandey VB, Kankare SB. Serum cystatin C as a marker of renal function in detection of early acute kidney injury. Indian J Nephrol. 2013;23(3):180-183.
[2] Grubb AO. Cystatin C—properties and use as diagnostic marker. Adv Clin Chem. 2000;35:63-99.
[3] Laterza OF, Price CP, Scott MG. Cystatin C: an improved estimator of glomerular filtration rate? Clin Chem.2002;48(5):699-707.
[4] Peralta CA, Katz R, Sarnak MJ, et al. Cystatin C identifies chronic kidney disease patients at higher risk for complications. J Am Soc Nephrol. 2011;22(1):147-155.
[5] Shlipak MG, Katz R, Cushman M, et al. Cystatin-C and inflammatory markers in the elderly: the Cardiovascular Health Study. Kidney Int. 2005;68(5):2281-2287.
[6] Randers E, Erlandsen EJ. Serum cystatin C as an endogenous marker of the renal function—a review. Clin Chem Lab Med. 1999;37(4):389-395.
[7] Hojs R, Bevc S, Ekart R, et al. Serum cystatin C-based formulas for estimation of glomerular filtration rate in patients with chronic kidney disease. Nephron Clin Pract. 2010;114(2).
[8] Roos JF, Doust J, Tett SE, Kirkpatrick CM. Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children—a meta-analysis. Clin Biochem. 2007;40(5-6):383-391.
[9] Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis. 2002;40(2):221-226.
[10] Tangri N, Stevens LA, Griffith J, et al. A predictive model for progression of chronic kidney disease to kidney failure. JAMA. 2011;305(15):1553-1559.
[11] Christensson AG, Grubb A, Nilsson JA, et al. Serum cystatin C advantageous compared with serum creatinine as a marker of GFR in patients with reduced glomerular filtration rate, and in renal transplant recipients. Nephrol Dial Transplant. 2003;18(4):681-686.
[12] Shlipak MG, Sarnak MJ, Katz R, et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med. 2005;352(20):2049-2060.
[13] Astor BC, Shafi T, Hoogeveen RC, et al. Novel markers of kidney function as predictors of ESRD, cardiovascular disease, and mortality in the general population. Am J Kidney Dis. 2012;59(5):653-662.
[14] Zahran A, Elsayad H, Ghareeb M, et al. The value of cystatin C as a marker of early renal impairment in type 2 diabetes. Saudi J Kidney Dis Transpl. 2007;18(4):551-555.
[15] Poge U, Gerhardt T, Stoffel-Wagner B, et al. Cystatin C as an endogenous marker of renal function in renal transplant patients. Kidney Int. 2004;66(1):623-631.

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