top of page

Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

lab-scientists-blood-urine-test-analysis

Eicosapentaenoic Acid-to-Arachidonic Acid Ratio

examining-blood-sample-with-microscope

EPA / AA

Description

"Eicosapentaenoic Acid-to-Arachidonic Acid (EPA/AA) Ratio" test measures the relationship between anti-inflammatory omega-3 and pro-inflammatory omega-6 fats in your blood. It’s used to evaluate chronic inflammation and cardiovascular risk. Doctors may recommend this test if you have fatigue, joint discomfort, or signs of immune imbalance. A low ratio can suggest insufficient omega-3 intake, while higher values typically indicate better inflammatory control. Results guide anti-inflammatory nutrition plans. This test supports long-term strategies for reducing metabolic and cardiovascular risk.

"Eicosapentaenoic Acid-to-Arachidonic Acid (EPA/AA) Ratio" test measures the relationship between anti-inflammatory omega-3 and pro-inflammatory omega-6 fats in your blood. It’s used to evaluate chronic inflammation and cardiovascular risk. Doctors may recommend this test if you have fatigue, joint discomfort, or signs of immune imbalance. A low ratio can suggest insufficient omega-3 intake, while higher values typically indicate better inflammatory control. Results guide anti-inflammatory nutrition plans. This test supports long-term strategies for reducing metabolic and cardiovascular risk.

Category

Fatty Acids

Procedure

Invasive

Sample Type

Blood – Plasma

Units

Ratio

Procedure Category

Blood Draw

Test Group

Omega Fatty Acid Group, Fatty Acid Group, Cognitive Health Group

Test Group Description

Cognitive Health Group: This group of tailored tests is aimed at evaluating cognitive function and assessing markers related to cognitive health, providing valuable insights for cognitive well-being and potential cognitive disorders. Fatty Acid Group: Evaluates fatty acid levels, offering insights into lipid metabolism and associated health conditions. Omega Fatty Acid Group: By evaluating the levels of essential omega fatty acids, this group provides insights into their presence and balance in the body, crucial for supporting cardiovascular health, brain function, and inflammation regulation.

Optimal Range

For All Individuals:

  • Conventional Unit: 0.25–0.40 R

  • SI Unit: Not Frequently Used

Normal Range

For All Individuals:

  • Conventional Unit: >0.17 R

  • SI Unit: Not Frequently Used

Results That Differ From The Norm (Direct and Indirect Causes)

Abnormal results may indicate:


  • Anxiety (Psychological condition characterized by excessive worry and fear)

  • Cancer

  • Cardiovascular disease (Conditions affecting the heart and blood vessels, including heart disease and stroke)

  • Depression

  • Dietary imbalance

  • Genetic factors (Inherited traits that can influence various aspects of health, inclu...

Key Reasons For Testing

  • Omega-3 to Omega-6 Balance: The EPA:AA ratio reflects the balance between these essential fatty acids in the body.

  • Inflammation Modulation: A higher ratio supports an anti-inflammatory state, reducing inflammation-related health risks.

  • Cardiovascular Health: Linked to reduced risks of coronary artery disease and atherosclerosis through anti-inflammatory effects.

  • Brain and Mood Support: Influences brain function, cognitive performance, and mood, benefiting conditions like depression.

  • Dietary Assessment: Guides dietary changes to optimize omega-3 and omega-6 intake for better health.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Harris WS, Von Schacky C. The Omega-3 Index: A new risk factor for death from coronary heart disease? Prev Med.2004;39(1):212-220.
[2] Siscovick DS, Barringer TA, Fretts AM, et al. Omega-3 polyunsaturated fatty acid (fish oil) supplementation and the prevention of clinical cardiovascular disease: A science advisory from the American Heart Association. Circulation.2017;135(15).
[3] Calder PC. Omega-3 fatty acids and inflammatory processes: From molecules to man. Biochem Soc Trans.2017;45(5):1105-1115.
[4] Mori TA, Woodman RJ. The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans. Curr Opin Clin Nutr Metab Care. 2006;9(2):95-104.
[5] Harris WS, Mozaffarian D, Rimm E, et al. Omega-6 fatty acids and risk for cardiovascular disease: A science advisory from the American Heart Association Nutrition Subcommittee. Circulation. 2009;119(6):902-907.
[6] Kiecolt-Glaser JK, Belury MA, Andridge R, et al. Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: A randomized controlled trial. Brain Behav Immun. 2012;26(6):988-995.
[7] Simopoulos AP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood). 2008;233(6):674-688.
[8] Blasbalg TL, Hibbeln JR, Ramsden CE, Majchrzak SF, Rawlings RR. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am J Clin Nutr. 2011;93(5):950-962.
[9] Balk EM, Lichtenstein AH, Chung M, Kupelnick B, Chew P, Lau J. Effects of omega-3 fatty acids on coronary restenosis, arrhythmias, and exercise tolerance: A systematic review. Atherosclerosis. 2006;185(1):1-20.
[10] Flock MR, Skulas-Ray AC, Harris WS, et al. Omega-3 fatty acid supplementation and risk for cardiovascular disease. Curr Atheroscler Rep. 2013;15(6):406.
[11] Albert CM, Campos H, Stampfer MJ, et al. Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med. 2002;346(15):1113-1118.
[12] Lands WE. Dietary fat and health: The evidence and the politics of prevention. Adv Nutr. 2012;3(3):321-332.
[13] MacLean CH, Newberry SJ, Mojica WA, et al. Effects of omega-3 fatty acids on cancer risk: A systematic review. JAMA. 2006;295(4):403-415.
[14] Yamagishi K, Iso H, Date C, et al. Fish, omega-3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwide community-based cohort of Japanese men and women. J Am Coll Cardiol. 2008;52(12):988-996.
[15] Jump DB, Depner CM, Tripathy S, Lytle KA. Potential for dietary omega-3 fatty acids to prevent nonalcoholic fatty liver disease and reduce the risk of primary liver cancer. Adv Nutr. 2015;6(6):694-702.
[16] Brown MD, Stojanovska L, Pilkington S, Byles J. Omega-3 fatty acids, bone health, and osteoporosis. Curr Osteoporos Rep. 2016;14(6):528-537.
[17] Wu JH, Lemaitre RN, King IB, et al. Association of plasma phospholipid long-chain omega-3 fatty acids with incident atrial fibrillation in older adults: The Cardiovascular Health Study. Circulation. 2012;125(9):1084-1093.

If You Found This Test Helpful, You Might Also Like..

bottom of page