top of page

Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

lab-scientists-blood-urine-test-analysis

High-Density Lipoprotein Cholesterol Size

different-type-serum-containing-blood-samples

HDL C S

Description

"High-Density Lipoprotein (HDL) Cholesterol Size" test analyzes whether your HDL particles are large or small—key for understanding cardiovascular protection. Larger particles are considered more effective at removing cholesterol, while smaller ones may increase heart disease risk. Doctors recommend this test when deeper insight is needed beyond standard cholesterol panels. Results help refine care plans, including exercise, diet, or medications. Tracking HDL particle size provides a more complete picture of lipid health and supports proactive cardiovascular care.

"High-Density Lipoprotein (HDL) Cholesterol Size" test analyzes whether your HDL particles are large or small—key for understanding cardiovascular protection. Larger particles are considered more effective at removing cholesterol, while smaller ones may increase heart disease risk. Doctors recommend this test when deeper insight is needed beyond standard cholesterol panels. Results help refine care plans, including exercise, diet, or medications. Tracking HDL particle size provides a more complete picture of lipid health and supports proactive cardiovascular care.

Test Category

Lipids, Proteins

Procedure

Invasive

Sample Type

Blood – Serum

Units

Nanometers

Procedure Category

Blood Draw

Test Group

Complete Cardiovascular Group, Lipoprotein Fractionation Group

Test Group Description

Complete Cardiovascular Group: This group contains comprehensive tests for an extensive evaluation of cardiovascular health, providing thorough insights into heart-related conditions beyond basic assessments. Lipoprotein Fractionation Group: Analyzes lipoprotein fractions through NMR technology, providing detailed insights into lipid metabolism and cardiovascular health.

Optimal Range

For All Individuals:

  • Conventional Unit: Large HDL: ≥9.0 nm

  • SI Unit: Not Applicable

Normal Range

For All Individuals:

  • Conventional Unit: Small HDL: 7.3–8.2 nm | Medium HDL: 8.3–9.3 nm | Large HDL: 9.4–14.0 nm

  • SI Unit: Not Applicable

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Alcohol consumption (Excessive intake of alcoholic beverages)

  • Cholestasis (Impaired bile flow from the liver)

  • Estrogen replacement therapy

  • Genetic factors (Inherited traits affecting HDL particle number)

  • Healthy fat consumption

  • Medications (such as nicotinic acid and fibrates)

  • ...

Key Reasons For Testing

  • Cardiovascular Risk Insights: HDL cholesterol size offers a refined evaluation of cardiovascular risk, enhancing traditional lipid profile assessments.

  • Atherosclerosis Risk Evaluation: Larger HDL particles are linked to greater cardiovascular protection, aiding in atherosclerosis risk prediction.

  • Lipid Subtype Analysis: Measures HDL particle distribution, offering insights into varied impacts on cardiovascular health.

  • ...

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Kontush A, Chapman MJ. Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis. Pharmacol Rev. 2006;58(3):342-374.
[2] Rosenson RS, Brewer HB Jr, Ansell BJ, et al. Dysfunctional HDL and atherosclerotic cardiovascular disease. Nat Rev Cardiol. 2016;13(1):48-60.
[3] Mackey RH, Greenland P, Goff DC Jr, Lloyd-Jones D, Sibley CT, Mora S. High-density lipoprotein cholesterol and particle concentrations, factor VII, and the risk of coronary heart disease. Arterioscler Thromb Vasc Biol.2012;32(9):2282-2290.
[4] deGoma EM, deGoma RL, Rader DJ. Beyond high-density lipoprotein cholesterol levels: evaluating high-density lipoprotein function as influenced by novel therapeutic approaches. J Am Coll Cardiol. 2008;51(23):2199-2211.
[5] Khera AV, Cuchel M, de la Llera-Moya M, et al. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med. 2011;364(2):127-135.
[6] Rosenson RS, Otvos JD, Freedman DS. Relations of lipoprotein subclass levels and low-density lipoprotein size to progression of coronary artery disease in the Pravastatin Limitation of Atherosclerosis in the Coronaries (PLAC-I) trial. Am J Cardiol. 2002;90(2):89-94.
[7] Barter PJ, Nicholls S. HDL and atherosclerosis: the negative clinical trial. J Am Coll Cardiol. 2006;47(7):1323-1326.
[8] Mora S, Otvos JD, Rosenson RS, et al. Lipoprotein particle size and concentrations by nuclear magnetic resonance and incident type 2 diabetes in women. Diabetes. 2010;59(5):1153-1160.
[9] Otvos JD, Mora S, Shalaurova I, Greenland P, Mackey RH, Goff DC Jr. Clinical implications of discordance between low-density lipoprotein cholesterol and particle number. J Clin Lipidol. 2011;5(2):105-113.
[10] Hoenig MR. LDL-C vs HDL particle size and density in assessing cardiovascular risk: what is the role of particle size analysis? Clin Chem. 2010;56(11):1527-1529.
[11] Matyus SP, Braun PJ, Wolak-Dinsmore J, et al. HDL particle number measured on the Vantera® Clinical Analyzer accurately predicts cardiovascular events in women: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Clin Chem. 2015;61(3):539-548.
[12] Lamarche B, Tchernof A, Moorjani S, Cantin B, Dagenais GR, Lupien PJ. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Circulation. 1997;95(1):69-75.
[13] Heinecke JW. The HDL proteome: a marker—and perhaps mediator—of coronary artery disease. J Lipid Res.2009;50(Suppl):S167-S171.

If You Found This Test Helpful, You Might Also Like..

bottom of page