Immunoglobulin A
IGA
Description
"Immunoglobulin A" (IgA) test measures the amount of IgA antibodies in your blood, which play a vital role in protecting mucous membranes in the respiratory and digestive tracts. It’s typically ordered when symptoms like frequent infections, gut issues, or suspected immune deficiency appear. Low IgA may suggest an immune disorder, while high levels can be linked to autoimmune disease or liver conditions. The results support diagnosis and care planning. Regular testing helps track immune function and guide treatment effectiveness.
Category
Antibodies
Procedure
Invasive
Sample Type
Blood – Serum
Units
Milligrams Per Deciliter
Procedure Category
Blood Draw
Test Group
Immune System Group
Test Group Description
Immune System Group: By evaluating various aspects of immune system function and health, this group offers insights into immune responses and related health considerations.
Optimal Range
For All Individuals:
Conventional Unit: Not Available
SI Unit: Not Available
Normal Range
For All Individuals:
Conventional Unit: 70.00–400.00 mg/dL
SI Unit: 70.00–400.00 mg/dL
Results That Differ From The Norm (Direct and Indirect Causes)
Increased levels may indicate:
Chronic infections
Cirrhosis (Liver scarring)
Hepatitis (Inflammation of the liver)
Inflammatory bowel disease (Chronic inflammation of the digestive tract)
Chronic lymphocytic leukemia (Cancer affecting white blood cells)
Lymphoma (Cancer of the lymphatic system)
- ...
Key Reasons For Testing
Mucosal Immunity: Evaluates IgA to assess defenses at respiratory and gastrointestinal surfaces.
IgA Deficiency: Detects low levels linked to recurrent infections and immunodeficiency.
Autoimmune Diseases: Measures IgA to monitor lupus, rheumatoid arthritis, or related conditions.
Allergic Conditions: Identifies elevated IgA in asthma, dermatitis, or allergic responses.
Gastrointestinal Disorders: Screens for celiac disease and other digestive issues.
Therapy Monitoring: Tracks IgA during treatment for conditions like IgA nephropathy.
Health Status Conditions It May Be Used To Assess
Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.
Some Prominent Medical Labs That May Offer This Test
Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.
References
Important Note
Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.
Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.
Disclaimer
This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.
Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.
[1] Yang J, Chen S, Chen L, Ouyang M, Li F. Chronic diarrhea associated with high serum level of immunoglobulin A and diffuse infiltration of plasma cells in small intestine: A case report. Medicine (Baltimore). 2017;96(5).
[2] Conley ME, Cooper MD. Immune dysregulation and IgA deficiency. J Clin Immunol. 1981;1(1):13-23.
[3] Tomasi TB Jr, Tan EM, Solomon A, Prendergast RA. Characteristics of an immune system common to certain external secretions. J Exp Med. 1965;121:101-124.
[4] Brandtzaeg P. The mucosal immune system and its integration with the mammary glands. J Pediatr Gastroenterol Nutr. 2013;56(Suppl 1).
[5] Janzi M, Kull I, Sjöberg R, et al. Selective IgA deficiency in early life: association to infections and allergic diseases during childhood. Clin Immunol. 2009;133(1):78-85.
[6] Boes M. Role of natural and immune IgM antibodies in immune responses. Mol Immunol. 2000;37(18):1141-1149.
[7] Kutteh WH, Prince SJ, Hammond KR, Kutteh CC, Mestecky J. Variations in immunoglobulins and protein profiles in human cervical mucus. Am J Obstet Gynecol. 1990;163(2):341-346.
[8] Natvig IB, Trondsen M, Brandtzaeg P. Function of secretory immunoglobulin A in immune exclusion at mucosal surfaces. Ann NY Acad Sci. 1974;235:81-93.
[9] Brandtzaeg P, Farstad IN. The human mucosal B-cell system in health and disease. Immunol Rev. 1999;171:45-87.
[10] Macpherson AJ, Geuking MB, Slack E, Hapfelmeier S, McCoy KD. The habitat of intestinal bacteria in the absence of secretory IgA. Gastroenterology. 2008;135(2):527-538.