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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Immunoglobulin G

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IGG

Description

"Immunoglobulin G" (IgG) test evaluates the most abundant type of antibody in your blood, which helps fight infections and build long-term immune memory. Doctors often use this test to investigate chronic illness, immune deficiency, or autoimmune conditions. Low IgG may point to immune suppression, while high levels can reflect persistent inflammation or immune overactivity. It’s particularly helpful for patients with recurrent infections or vaccine response concerns. Results guide personalized care and support long-term immune system monitoring.

"Immunoglobulin G" (IgG) test evaluates the most abundant type of antibody in your blood, which helps fight infections and build long-term immune memory. Doctors often use this test to investigate chronic illness, immune deficiency, or autoimmune conditions. Low IgG may point to immune suppression, while high levels can reflect persistent inflammation or immune overactivity. It’s particularly helpful for patients with recurrent infections or vaccine response concerns. Results guide personalized care and support long-term immune system monitoring.

Test Category

Antibodies

Procedure

Invasive

Sample Type

Blood – Serum

Units

Milligrams Per Deciliter

Procedure Category

Blood Draw

Test Group

Immune System Group

Test Group Description

Immune System Group: By evaluating various aspects of immune system function and health, this group offers insights into immune responses and related health considerations.

Optimal Range

For All Individuals:

  • Conventional Unit: 700–1600 mg/dL

  • SI Unit: 700–1600 mg/dL

Normal Range

For All Individuals:

  • Conventional Unit: 600–1700 mg/dL

  • SI Unit: 600–1700 mg/dL

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Chronic infections

  • Cirrhosis (Liver scarring)

  • Hepatitis (Inflammation of the liver)

  • Inflammatory bowel disease (Chronic inflammation of the digestive tract)

  • Chronic lymphocytic leukemia (Cancer affecting white blood cells)

  • Lymphoma (Cancer of the lymphatic system)

  • ...

Key Reasons For Testing

  • Primary Immune Response: Evaluates IgG as the primary antibody in long-term immunity.

  • Infection Detection: Identifies past or ongoing infections through specific antibody levels.

  • Immune Status: Assesses IgG levels to evaluate immune function and susceptibility to infections.

  • Autoimmune Disorders: Detects abnormal IgG levels associated with autoimmune conditions.

  • Allergy Testing (Limited Role): Explores IgG involvement in allergic responses, though it is less prominent than IgE.

  • Vaccination Monitoring: Tracks IgG levels post-vaccination to evaluate immunity development and vaccine efficacy.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Vidarsson G, Dekkers G, Rispens T. IgG subclasses and allotypes: from structure to effector functions. Front Immunol. 2014;5:520.
[2] Ballow M. Primary immunodeficiency disorders: antibody deficiency. J Allergy Clin Immunol. 2002;109(4):581-591.
[3] Schroeder HW Jr, Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol. 2010;125(2 Suppl 2).
[4] Burton DR, Woof JM. Human antibody effector function. Adv Immunol. 1992;51:1-84.
[5] Wrammert J, Koutsonanos D, Li GM, et al. Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. J Exp Med. 2011;208(1):181-193.
[6] Shakib F, Stanworth DR. Human immunoglobulin subclasses in health and disease. Clin Exp Immunol.1980;40(3):347-358.
[7] McLean GR, Torres M, Elguezabal N, Nakouzi A, Casadevall A. Isotype can affect the fine specificity of an antibody for a polysaccharide antigen. J Immunol. 2002;169(3):1379-1386.
[8] Jefferis R. Glycosylation of human IgG antibodies: relevance to therapeutic antibodies. J Clin Immunol.2001;21(6):399-408.
[9] Vidarsson G, Stemerding AM, Stapels DA, et al. FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis. Blood. 2006;108(10):3573-3579.
[10] Parameswaran N, Patial S. Tumor necrosis factor-α signaling in macrophages. Crit Rev Eukaryot Gene Expr.2010;20(2):87-103.
[11] Aalberse RC, Stapel SO, Schuurman J, Rispens T. Immunoglobulin G4: an odd antibody. Clin Exp Allergy.2009;39(4):469-477.
[12] Bloch-Michel E, Nussenblatt RB. International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease. Am J Ophthalmol. 1987;103(2):234-235.
[13] Vidarsson G, Foss S, Øynebråten I. The Antibody Fc Receptor Family. Handb Exp Pharmacol. 2018;243:155-174.

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