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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Insulin Tolerance

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ITT

Description

"Insulin Tolerance" test measures how your body responds to insulin by monitoring blood sugar changes after a controlled insulin dose. Doctors use it to investigate insulin sensitivity and detect adrenal or metabolic dysfunction. Low glucose response may suggest insulin resistance, while extreme drops could indicate adrenal issues. This test helps evaluate symptoms like fatigue, dizziness, or blood sugar instability. Results support treatment adjustments and provide insight into how your body handles insulin over time.

"Insulin Tolerance" test measures how your body responds to insulin by monitoring blood sugar changes after a controlled insulin dose. Doctors use it to investigate insulin sensitivity and detect adrenal or metabolic dysfunction. Low glucose response may suggest insulin resistance, while extreme drops could indicate adrenal issues. This test helps evaluate symptoms like fatigue, dizziness, or blood sugar instability. Results support treatment adjustments and provide insight into how your body handles insulin over time.

Test Category

Hormones

Procedure

Invasive

Sample Type

Blood – Serum

Units

Milligrams Per Deciliter | Millimoles Per Liter | Micrograms Per Deciliter | Nanomoles Per Liter | Micrograms Per Liter

Procedure Category

Inject, Blood Draw

Test Group

Complete Blood Sugar Group, Pancreas Group, Complete Metabolic Group

Test Group Description

Complete Blood Sugar Group: This expanded group includes a more comprehensive set of tests, offering a thorough evaluation of diverse facets of blood sugar levels for a more detailed understanding of metabolic health. Pancreas Group: Tests within this group focus on assessing the function and health of the pancreas, a vital organ involved in digestion and blood sugar regulation. These tests provide insights into pancreatic enzymes, hormone levels, and overall pancreatic function. Complete Metabolic Group: A comprehensive suite of tests designed to evaluate metabolic function, offering detailed insights into various aspects of metabolism and associated health conditions.

Optimal Range

For All Individuals:

  • Conventional Unit: Glucose Nadir: Not Applicable | Cortisol Peak: Not Applicable | Growth Hormone Peak: Not Applicable

  • SI Unit: Glucose Nadir: Not Applicable | Cortisol Peak: Not Applicable | Growth Hormone Peak: Not Applicable

Normal Range

For All Individuals:

  • Conventional Unit: Glucose Nadir: <40 mg/dL | Cortisol Peak: >20 µg/dL | Growth Hormone Peak: >7 µg/L

  • SI Unit: Glucose Nadir: <2.2 mmol/L | Cortisol Peak: >550 nmol/L | Growth Hormone Peak: >7 µg/L

Results That Differ From The Norm (Direct and Indirect Causes)

Abnormal results may indicate:


  • Adrenal insufficiency (Adrenal gland doesn't produce enough hormones)

  • Acromegaly (Excessive growth hormone production)

  • Cirrhosis (Liver scarring)

  • Cushing's syndrome (Excessive cortisol hormone)

  • Donohue syndrome (Rare inherited disorder affecting insulin receptors)

  • Glucocorticoid medication use (Use of medi...

Key Reasons For Testing

  • Evaluation of Insulin Sensitivity: Assesses the body’s response to insulin.

  • Diagnostic Tool for Hypoglycemia: Identifies hypoglycemia and related conditions.

  • Assessment of Pancreatic Function: Evaluates insulin release and glucose regulation.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

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[2] Bonora E, Moghetti P, Zancanaro C, et al. Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J Clin Endocrinol Metab. 1989;68(2):374-378.
[3] Wilcox G. Insulin and insulin resistance. Clin Biochem Rev. 2005;26(2):19-39.
[4] Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia.1985;28(7):412-419.
[5] Muniyappa R, Lee S, Chen H, Quon MJ. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab. 2008;294(1).
[6] Radikova Z. Assessment of insulin sensitivity/resistance in epidemiological studies. Endocr Regul. 2003;37(3):189-194.
[7] DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237(3).
[8] Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, DeFronzo RA. Thiazolidinediones improve beta-cell function in type 2 diabetic patients. Am J Physiol Endocrinol Metab. 2007;292(3).
[9] Tam CS, Xie W, Johnson WD, Cefalu WT, Redman LM, Ravussin E. Defining insulin resistance from hyperinsulinemic-euglycemic clamps. Diabetes Care. 2012;35(7):1605-1610.
[10] Antuna-Puente B, Disse E, Rabasa-Lhoret R, Laville M, Capeau J, Bastard JP. How can we measure insulin sensitivity/resistance? Diabetes Metab. 2011;37(3):179-188.
[11] Pratley RE, Weyer C. The role of impaired early insulin secretion in the pathogenesis of type II diabetes mellitus. Diabetologia. 2001;44(8):929-945.
[12] Templeman NM, Skovsø S, Page MM, Lim GE, Johnson JD. A causal role for hyperinsulinemia in obesity. J Endocrinol. 2017;232(3).
[13] Shanik MH, Xu Y, Skrha J, Dankner R, Zick Y, Roth J. Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse? Diabetes Care. 2008;31(Suppl 2).
[14] Abdul-Ghani MA, Tripathy D, DeFronzo RA. Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care. 2006;29(5):1130-1139.

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