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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Interleukin-1 Beta

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IL-1B

Description

"Interleukin-1 Beta" (IL-1β) test measures levels of this pro-inflammatory cytokine in your blood to assess immune system activity. Doctors may use it when autoimmune conditions, chronic inflammation, or infections are suspected. Elevated IL-1β can signal diseases like rheumatoid arthritis, inflammatory bowel disease, or systemic inflammation. A blood sample reveals your IL-1β level and helps guide diagnosis or treatment adjustments. Ongoing testing supports inflammation tracking and helps personalize therapies that target immune-related symptoms.

"Interleukin-1 Beta" (IL-1β) test measures levels of this pro-inflammatory cytokine in your blood to assess immune system activity. Doctors may use it when autoimmune conditions, chronic inflammation, or infections are suspected. Elevated IL-1β can signal diseases like rheumatoid arthritis, inflammatory bowel disease, or systemic inflammation. A blood sample reveals your IL-1β level and helps guide diagnosis or treatment adjustments. Ongoing testing supports inflammation tracking and helps personalize therapies that target immune-related symptoms.

Test Category

Cytokines, Inflammatory Markers

Procedure

Invasive

Sample Type

Blood – Serum

Units

Picograms Per Milliliter | Nanograms Per Liter

Procedure Category

Blood Draw

Test Group

Complete Inflammation Group, Immune System Group

Test Group Description

Complete Inflammation Group: Extensive tests offer a comprehensive assessment of inflammatory markers, yielding detailed insights into inflammation levels and related health conditions. Immune System Group: By evaluating various aspects of immune system function and health, this group offers insights into immune responses and related health considerations.

Optimal Range

For All Individuals:

  • Conventional Unit: <3.00 pg/mL

  • SI Unit: <3.00 ng/L

Normal Range

For All Individuals:

  • Conventional Unit: <6.70 pg/mL

  • SI Unit: <6.70 ng/L

Results That Differ From The Norm (Direct and Indirect Causes)

Abnormal results may indicate:


  • Allergic reactions

  • Ankylosing spondylitis (Inflammatory arthritis affecting the spine and large joints)

  • Alzheimer's disease (Neurodegenerative disorder leading to cognitive decline)

  • Asthma (Chronic respiratory condition characterized by airway inflammation)

  • Atherosclerosis (Buildup of plaque in arteries leading to heart disease)

  • ...

Key Reasons For Testing

  • Inflammatory Marker: Elevated IL-1β indicates acute and chronic inflammation.

  • Autoimmune Diseases: Increased IL-1β is linked to conditions like rheumatoid arthritis and inflammatory bowel disease.

  • Infections: Reflects immune response to bacterial, viral, and fungal infections.

  • Cardiovascular Health: Elevated levels indicate risks of atherosclerosis and coronary artery disease.

  • Therapeutic Monitoring: Tracks treatment response in inflammatory conditions.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Dinarello CA. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood. 2011;117(14):3720-3732.
[2] Gabay C, Lamacchia C, Palmer G. IL-1 pathways in inflammation and human diseases. Nat Rev Rheumatol.2010;6(4):232-241.
[3] Arend WP, Malyak M, Guthridge CJ, Gabay C. Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol.1998;16:27-55.
[4] Netea MG, van de Veerdonk FL, van der Meer JW, Dinarello CA, Joosten LA. Inflammasome-independent regulation of IL-1-family cytokines. Annu Rev Immunol. 2015;33:49-77.
[5] Fantuzzi G, Dinarello CA. Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1). J Clin Immunol. 1999;19(1):1-11.
[6] Sims JE, Smith DE. The IL-1 family: regulators of immunity. Nat Rev Immunol. 2010;10(2):89-102.
[7] Dinarello CA, Simon A, van der Meer JW. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov. 2012;11(8):633-652.
[8] Kostulas N, Pelidou SH, Kivisakk P, Kostulas V, Link H. Increased IL-1beta, IL-8, and IL-10 mRNA expression in multiple sclerosis and optic neuritis lesions: an in situ hybridization study. J Neuroimmunol. 1999;95(1-2):1-8.
[9] Isoda K, Sawada S, Ayaori M, et al. Deficiency of interleukin-1 receptor antagonist promotes neointimal formation after injury. Circulation. 2003;108(8):1002-1005.
[10] Labzin LI, Heneka MT, Latz E. Innate immunity and neurodegeneration. Annu Rev Med. 2018;69:437-449.
[11] Guma M, Tiziani S, Firestein GS. Metabolomics reveals altered intracellular glucose and myo-inositol levels in rheumatoid arthritis synoviocytes. J Biol Chem. 2013;288(29):22254-22262.
[12] Weiss G, Schaible UE. Macrophage defense mechanisms against intracellular bacteria. Immunol Rev.2015;264(1):182-203.

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