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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Leucine

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LEU

Description

"Leucine" test evaluates the amount of leucine in your blood, an amino acid critical for protein synthesis, muscle repair, and energy production. It’s frequently used to monitor metabolic disorders such as maple syrup urine disease (MSUD) or assess nutritional status. Elevated levels may signal enzyme dysfunction or protein metabolism issues, while low levels might reflect dietary shortfalls or increased demand during illness. This test helps doctors recommend interventions like dietary changes, supplements, or further monitoring for metabolic health.

"Leucine" test evaluates the amount of leucine in your blood, an amino acid critical for protein synthesis, muscle repair, and energy production. It’s frequently used to monitor metabolic disorders such as maple syrup urine disease (MSUD) or assess nutritional status. Elevated levels may signal enzyme dysfunction or protein metabolism issues, while low levels might reflect dietary shortfalls or increased demand during illness. This test helps doctors recommend interventions like dietary changes, supplements, or further monitoring for metabolic health.

Category

Amino Acids

Procedure

Invasive

Sample Type

Blood – Plasma

Units

Nanomoles Per Milliliter

Procedure Category

Blood Draw

Test Group

Amino Acid Group

Test Group Description

Amino Acid Group: Tests in this group analyze amino acid levels in the body, providing valuable insights into protein metabolism and potential genetic or metabolic disorders related to amino acid processing.

Optimal Range

For All Individuals:

  • Conventional Unit: 100.00–150.00 µmol/L

  • SI Unit: 100.00–150.00 µmol/L

Normal Range

For All Individuals:

  • Conventional Unit: 54.90–205.00 µmol/L

  • SI Unit: 54.90–205.00 µmol/L

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Significant BCAA supplementation

  • High protein consumption

  • Maple Syrup Urine Disease (A rare metabolic disorder affecting the breakdown of certain amino acids)

  • Vitamin B1 deficiency

  • Vitamin B6 deficiency


Decreased levels ma...

Key Reasons For Testing

  • Muscle Protein Synthesis: Reflects leucine’s role in muscle growth and repair.

  • Blood Sugar Regulation: Indicates its impact on insulin sensitivity and secretion.

  • Muscle Preservation: Assesses preservation of lean mass during caloric restriction.

  • Wound Healing: Monitors tissue repair and recovery potential.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Layman DK, Walker DA. Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr. 2006;136(1 Suppl):319S-323S.
[2] Holecek M. Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements. Nutr Metab (Lond). 2018;15:33.
[3] Kimball SR, Jefferson LS. Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr. 2006;136(1 Suppl):227S-231S.
[4] Lynch CJ, Adams SH. Branched-chain amino acids in metabolic signalling and insulin resistance. Nat Rev Endocrinol. 2014;10(12):723-736.
[5] Garlick PJ. The role of leucine in the regulation of protein metabolism. J Nutr. 2005;135(6 Suppl):1553S-1556S.
[6] Adeva MM, Calviño J, Souto G, Donapetry C. Insulin resistance and the metabolism of branched-chain amino acids in humans. Amino Acids. 2012;43(1):171-181.
[7] Moberg M, Apró W, Ekblom B, van Hall G, Holmberg HC, Blomstrand E. Activation of mTORC1 by leucine is potentiated by branched-chain amino acids and even more so by essential amino acids following resistance exercise. Am J Physiol Cell Physiol. 2016;310(11).
[8] Zanchi NE, Nicastro H, Lancha AH Jr. Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies. Nutr Metab (Lond). 2008;5:20.
[9] Newgard CB. Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metab. 2012;15(5):606-614.
[10] Drummond MJ, Rasmussen BB. Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis. Curr Opin Clin Nutr Metab Care. 2008;11(3):222-226.

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