Low-Density Lipoprotein Particle Number
LDL P
Description
"Low-Density Lipoprotein (LDL) Particle Number" test counts LDL particles in your blood to assess cardiovascular risk. Even if LDL cholesterol seems normal, a high particle count may signal increased risk for plaque buildup and atherosclerosis. Doctors use this test to uncover hidden risk in people with diabetes, metabolic syndrome, or borderline cholesterol. Based on results, they may adjust care plans through medications, nutrition, or exercise. Tracking LDL particle number over time helps guide targeted prevention and protect heart health.
Category
Lipids, Proteins
Procedure
Invasive
Sample Type
Blood – Serum
Units
Nanomoles Per Liter
Procedure Category
Blood Draw
Test Group
Complete Cardiovascular Group, Lipoprotein Fractionation Group
Test Group Description
Complete Cardiovascular Group: This group contains comprehensive tests for an extensive evaluation of cardiovascular health, providing thorough insights into heart-related conditions beyond basic assessments. Lipoprotein Fractionation Group: Analyzes lipoprotein fractions through NMR technology, providing detailed insights into lipid metabolism and cardiovascular health.
Optimal Range
For All Individuals:
Conventional Unit: <935 nmol/L
SI Unit: <935 nmol/L
Normal Range
For All Individuals:
Conventional Unit: <1,000 nmol/L
SI Unit: <1,000 nmol/L
Results That Differ From The Norm (Direct and Indirect Causes)
Increased levels may indicate:
Chronic kidney disease
Familial hypercholesterolemia (Genetic disorder causing high levels of cholesterol)
Hypothyroidism (Underactive thyroid gland)
Insulin resistance (Reduced responsiveness to insulin)
Medications (such as antipsychotics and corticosteroids)
Metabolic syndrome (cluster ...
Key Reasons For Testing
Cardiovascular Risk Assessment: Elevated numbers indicate higher risk of atherosclerosis and cardiovascular events.
Atherosclerosis Detection: Identifies individuals at risk of arterial plaque buildup.
Treatment Monitoring: Tracks cholesterol-lowering therapy effectiveness.
Coronary Artery Disease Risk Stratification: Provides insights into CAD progression and preventive care.
Response to Lifestyle Interventions: Reflects the impact of diet and exercise on cardiovascular health.
Health Status Conditions It May Be Used To Assess
Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.
Some Prominent Medical Labs That May Offer This Test
Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.
References
Important Note
Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.
Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.
Disclaimer
This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.
Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.
[1] Mora S, Buring JE, Ridker PM. Association of LDL particle concentration with red meat, but not dairy consumption, in men. J Am Heart Assoc. 2014;3(4).
[2] Otvos JD, Mora S, Shalaurova I, Greenland P, Mackey RH, Goff DC Jr. Clinical implications of discordance between low-density lipoprotein cholesterol and particle number. J Clin Lipidol. 2011;5(2):105-113.
[3] Sniderman AD, St-Pierre AC, Cantin B, Dagenais GR, Després JP, Lamarche B. Concordance/discordance between LDL cholesterol and apolipoprotein B: clinical significance of discordance for cardiovascular risk prediction. J Am Coll Cardiol. 2003;41(11):1859-1865.
[4] Mora S, Szklo M, Otvos JD, et al. LDL particle number, LDL cholesterol, and carotid atherosclerosis: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2007;192(1):211-217.
[5] Cromwell WC, Otvos JD. Low-density lipoprotein particle number and risk for cardiovascular disease. Curr Atheroscler Rep. 2004;6(5):381-387.
[6] Mora S, Otvos JD, Rifai N, Rosenson RS, Buring JE, Ridker PM. Lipoprotein particle profiles by nuclear magnetic resonance compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in women. Circulation. 2009;119(7):931-939.
[7] McQueen MJ, Hawken S, Wang X, et al. Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study. Lancet. 2008;372(9634):224-233.
[8] El Harchaoui K, van der Steeg WA, Stroes ES, et al. Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study. J Am Coll Cardiol. 2007;49(5):547-553.
[9] Otvos JD, Jeyarajah EJ, Cromwell WC. Measurement issues related to lipoprotein heterogeneity. Am J Cardiol. 2002;90(8A):22i-29i.
[10] Sniderman AD, Williams K, Contois JH, Monroe H, McQueen MJ, de Graaf J. A meta-analysis of low-density lipoprotein particle number and cardiovascular outcomes. Clin Chem. 2011;57(5):723-731.
[11] Contois JH, McConnell JP, Sethi AA, et al. Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices. Clin Chem. 2009;55(3):407-419.