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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Methionine

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MET

Description

"Methionine" test evaluates how much methionine, an essential amino acid, is present in your blood. It’s often ordered to investigate methylation issues, liver dysfunction, or suspected metabolic disorders like homocystinuria. High levels may indicate enzyme defects or dietary imbalance, while low levels suggest malabsorption or deficiency. Doctors use the results to tailor treatment with nutritional support or further testing. Tracking methionine helps manage amino acid metabolism, reduce symptom flare-ups, and support long-term cellular health.

"Methionine" test evaluates how much methionine, an essential amino acid, is present in your blood. It’s often ordered to investigate methylation issues, liver dysfunction, or suspected metabolic disorders like homocystinuria. High levels may indicate enzyme defects or dietary imbalance, while low levels suggest malabsorption or deficiency. Doctors use the results to tailor treatment with nutritional support or further testing. Tracking methionine helps manage amino acid metabolism, reduce symptom flare-ups, and support long-term cellular health.

Category

Amino Acids, Metabolites

Procedure

Invasive

Sample Type

Blood – Plasma

Units

Micromoles Per Liter

Procedure Category

Blood Draw

Test Group

Methylation Group

Test Group Description

Methylation Group: Centered on evaluating methylation levels and associated parameters, this group provides insights into methylation processes and their related health implications.

Optimal Range

For All Individuals:

  • Conventional Unit: Not Available

  • SI Unit: Not Available

Normal Range

For All Individuals:

  • Conventional Unit: 12.70–41.10 µmol/L

  • SI Unit: 12.70–41.10 µmol/L

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Cystathionine beta-synthase deficiency (Genetic disorder affecting methionine metabolism)

  • Excessive supplementation

  • Homocystinuria (Genetic disorder resulting in elevated homocysteine and methionine levels)

  • Kidney dysfunction

  • Hepatic failure (Liver dysfunction)

  • Methionine adenosyltransfera...

Key Reasons For Testing

  • Diagnosis of Methionine Metabolism Disorders: Detects conditions like homocystinuria and sulfur amino acid metabolism disorders.

  • Newborn Screening: Identifies inherited metabolic disorders early for prompt intervention.

  • Assessment of Liver Function: Evaluates methionine metabolism linked to liver health.

  • Evaluation of Nutritional Status: Assesses dietary intake of this essential amino acid.

  • Monitoring of Homocysteine Levels: Provides insights into cardiovascular risk and related health conditions.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Brosnan JT, Brosnan ME. The sulfur-containing amino acids: an overview. J Nutr. 2006;136(6 Suppl):1636S-1640S.
[2] Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. 1990;1(5):228-237.
[3] Lu SC. Regulation of hepatic S-adenosylmethionine synthesis and its role in liver disease. Hepatology. 2000;32(5):1343-1345.
[4] Zeisel SH. Methionine. Encyclopedia of Human Nutrition. 2nd ed. Elsevier; 2005:155-161.
[5] Mudd SH, Finkelstein JD, Refsum H, Ueland PM, Malinow MR, Lentz SR, Jacobsen DW. Homocysteine and its disulfide derivatives: a suggested consensus terminology. J Nutr. 2000;130(2):605-607.
[6] Storch KJ, Wagner DA, Burke JF, Young VR. Methionine kinetics in adult men: effects of dietary protein intake and tracer label selection. Am J Physiol. 1990;258(2 Pt 1).
[7] McCully KS. Homocysteine and vascular disease. Nat Med. 1996;2(4):386-389.
[8] Finkelstein JD, Martin JJ. Methionine metabolism in mammals. Adaptation to methionine excess. J Biol Chem. 1986;261(4):1582-1587.
[9] Refsum H, Ueland PM, Nygård O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med. 1998;49:31-62.
[10] Brosnan JT, da Silva RP, Brosnan ME. The metabolic burden of methionine metabolism in liver. J Nutr. 2007;137(6 Suppl):1736S-1741S.
[11] Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999;19:217-246.
[12] Malinow MR, Bostom AG, Krauss RM. Homocysteine, diet, and cardiovascular diseases: a statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation. 1999;99(1):178-182.

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