Myeloperoxidase
MPO
Description
"Myeloperoxidase" (MPO) test measures an enzyme produced by white blood cells that signals inflammation within your blood vessels. Elevated MPO levels can indicate oxidative stress and unstable plaque, raising the risk of heart attack or stroke. This test is especially valuable for those with high cholesterol or a family history of cardiovascular disease. Results help doctors refine your care plan through lifestyle changes, medications, or further testing. Ongoing monitoring supports early detection and long-term vascular health management.
Category
Enzymes
Procedure
Invasive
Sample Type
Blood – Serum
Units
Picomoles Per Liter
Procedure Category
Blood Draw
Test Group
Basic Cardiovascular Group, Enzyme Group, Complete Cardiovascular Group, Complete Inflammation Group
Test Group Description
Basic Cardiovascular Group: This group includes fundamental tests targeting essential markers related to cardiovascular health, providing foundational insights into cholesterol levels, blood pressure, and other key factors. Complete Cardiovascular Group: This group contains comprehensive tests for an extensive evaluation of cardiovascular health, providing thorough insights into heart-related conditions beyond basic assessments. Complete Inflammation Group: Extensive tests offer a comprehensive assessment of inflammatory markers, yielding detailed insights into inflammation levels and related health conditions. Enzyme Group: Evaluates enzyme levels and activity, offering insights into enzymatic function and related health conditions.
Optimal Range
For All Individuals:
Conventional Unit: < 470.00 pmol/L
SI Unit: Not Applicable
Normal Range
For All Individuals:
Conventional Unit: < 470.00 pmol/L
SI Unit: Not Applicable
Results That Differ From The Norm (Direct and Indirect Causes)
Increased levels may indicate:
Atherosclerosis (Buildup of plaque in the arteries)
Bronchitis (Inflammation of the bronchial tubes)
Chronic kidney disease (Long-term impairment of kidney function)
Chronic obstructive pulmonary disease (Progressive lung disease)
Crohn's disease (Chronic inflammatory bowel disease)
Myocar...
Key Reasons For Testing
Neutrophilic Inflammation Identification: Detects elevated MPO levels to differentiate inflammatory processes.
Inflammatory Response Assessment: Monitors neutrophil activation in conditions like arthritis and inflammatory bowel disease.
Cardiovascular Risk Evaluation: Predicts risks for heart attacks and strokes through MPO levels.
Acute Coronary Syndromes Diagnosis: Assists in diagnosing unstable angina and myocardial infarction.
Infection Detection: Identifies inflammatory responses to bacterial, viral, and fungal infections.
Health Status Conditions It May Be Used To Assess
Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.
Some Prominent Medical Labs That May Offer This Test
Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.
References
Important Note
Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.
Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.
Disclaimer
This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.
Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.
[1] Khan AA, Alsahli MA, Rahmani AH. Myeloperoxidase as an Active Disease Biomarker: Recent Biochemical and Pathological Perspectives. Med Sci (Basel). 2018;6(2):33.
[2] Tavora F, Burke AP, Zhao X, et al. Monocytes and neutrophils expressing myeloperoxidase occur in fibrous caps and thrombi in unstable coronary plaques. BMC Cardiovasc Disord. 2009;9:27.
[3] Hazen SL, Heinecke JW. 3-chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low-density lipoprotein isolated from human atherosclerotic intima. J Clin Invest. 1997;99(9):2075-2081.
[4] Fu X, Kassim SY, Parks WC, Heinecke JW. Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7): a mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase. J Biol Chem. 2001;276(44):41279-41287.
[5] Meuwese MC, Stroes ES, Hazen SL, et al. Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: The EPIC-Norfolk Prospective Population Study. J Am Coll Cardiol. 2007;50(2):159-165.
[6] Karakas M, Koenig W, Zierer A, et al. Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: Results from the MONICA/KORA Augsburg study. J Intern Med. 2012;271(1):43-50.
[7] Baldus S, Heeschen C, Meinertz T, et al. Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation. 2003;108(12):1440-1445.
[8] Cavusoglu E, Ruwende C, Chopra V, et al. Usefulness of baseline plasma myeloperoxidase levels as an independent predictor of myocardial infarction at two years in patients presenting with acute coronary syndrome. Am J Cardiol. 2007;99(10):1364-1368.
[9] Heslop CL, Frohlich JJ, Hill JS. Myeloperoxidase and C-reactive protein have combined utility for long-term prediction of cardiovascular mortality after coronary angiography. J Am Coll Cardiol. 2010;55(11):1102-1109.
[10] Shao B, Tang C, Heinecke JW. Orchestrated catabolism of apolipoprotein A-I by myeloperoxidase and plasmin generates dysfunctional high-density lipoprotein. J Biol Chem. 2010;285(48):32656-32665.
[11] Brennan ML, Penn MS, Van Lente F, et al. Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med. 2003;349(17):1595-1604.
[12] Buhlin K, Gustafsson A, Pockley AG, et al. Periodontitis is associated with angiographically verified coronary artery disease. J Clin Periodontol. 2011;38(11):1007-1014.