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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Osteocalcin

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OC

Description

"Osteocalcin" test evaluates levels of a key protein involved in bone formation, offering insight into how actively your body is building bone. Doctors often order this test when monitoring osteoporosis, bone metabolism disorders, or treatment response. Elevated or low osteocalcin levels may reflect imbalances in bone turnover. The results help tailor therapies such as supplements or medications. Regular osteocalcin testing supports long-term bone strength and provides a clearer picture of your skeletal health.

"Osteocalcin" test evaluates levels of a key protein involved in bone formation, offering insight into how actively your body is building bone. Doctors often order this test when monitoring osteoporosis, bone metabolism disorders, or treatment response. Elevated or low osteocalcin levels may reflect imbalances in bone turnover. The results help tailor therapies such as supplements or medications. Regular osteocalcin testing supports long-term bone strength and provides a clearer picture of your skeletal health.

Category

Proteins

Procedure

Invasive

Sample Type

Blood – Serum

Units

Nanograms Per Milliliter

Procedure Category

Blood Draw

Test Group

Bone Health Group

Test Group Description

Bone Health Group: This group encompasses tests vital for assessing bone health and detecting conditions related to bone metabolism.

Optimal Range

For All Individuals:

  • Conventional Unit: 13.50–16.00 ng/mL

  • SI Unit: Not Applicable

Normal Range

For All Individuals:

  • Conventional Unit: 8.00–32.00 ng/mL

  • SI Unit: Not Applicable

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Chronic kidney disease

  • Hyperparathyroidism (Overactivity of the parathyroid glands)

  • Hyperthyroidism (Overactive thyroid gland)

  • Menopause

  • Osteoporosis (Weakening of bones)

  • Paget's disease of bone (Bone disorder resulting in enlarged and misshapen bones)

  • Vita...

Key Reasons For Testing

  • Bone Health Assessment: Evaluates bone health by measuring osteocalcin levels, a key bone formation protein.

  • Bone Turnover Marker: Reflects the rate of bone remodeling and provides insights into bone metabolism.

  • Diagnosis of Bone Disorders: Identifies conditions like osteoporosis, osteomalacia, or Paget's disease.

  • Evaluation of Bone Formation: Assesses bone formation activity alongside other diagnostic tools.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Hauschka PV, Lian JB, Cole DE, Gundberg CM. Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiol Rev. 1989;69(3):990-1047.

[2] Khosla S, Westendorf JJ, Mödder UI. Concise review: Insights from normal bone remodeling and stem cell-based therapies for bone repair. Stem Cells. 2010;28(12):2124-2128.

[3] Gundberg CM, Nieman SD, Abrams S, Rosen H. Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin. J Clin Endocrinol Metab. 1998;83(9):3258-3266.

[4] Szulc P, Naylor K, Hoyle NR, Eastell R, Leary ET. Use of biochemical markers of bone turnover in postmenopausal osteoporosis: recommendations of the International Osteoporosis Foundation and the International Federation of Clinical Chemistry and Laboratory Medicine. Clin Chem Lab Med. 2017;55(4):577-591.

[5] Kanazawa I, Sugimoto T. Role of osteocalcin in regulating glucose metabolism: clinical evidence and potential mechanisms. Front Endocrinol (Lausanne). 2021;12:722058.

[6] Ivaska KK, Hentunen TA, Väänänen HK. Biochemical markers of bone metabolism. Clin Biochem. 2004;37(12):867-872.

[7] Reinehr T, Roth CL. A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and adiponectin. J Pediatr Endocrinol Metab. 2010;23(9):913-921.

[8] Lee NK, Sowa H, Hinoi E, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130(3):456-469.

[9] Ferron M, Lacombe J. Regulation of energy metabolism by the skeleton: osteocalcin and beyond. Arch Biochem Biophys. 2014;561:137-146.

[10] Trzeciakiewicz A, Habauzit V, Horcajada MN. When nutrition interacts with osteoblast function: molecular mechanisms of polyphenols. Nutr Res Rev. 2009;22(1):68-81.

[11] Price PA. Role of vitamin K-dependent proteins in bone metabolism. Annu Rev Nutr. 1988;8:565-583.

[12] Delmas PD. Biochemical markers of bone turnover: theoretical considerations and clinical use in osteoporosis. Am J Med. 1993;95(5A):11S-16S.

[13] Confavreux CB. Bone: from a reservoir of minerals to a regulator of energy metabolism. Kidney Int Suppl (2011). 2011;79(121):S14-S19.

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