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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Pyruvate

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PYR

Description

"Pyruvate" test evaluates pyruvate levels in your blood, a key compound involved in converting food into usable energy. Doctors may recommend this test when symptoms like chronic fatigue, muscle weakness, or neurological changes suggest a mitochondrial or metabolic issue. These imbalances can reflect impaired cellular energy production or signal underlying lactic acidosis. A blood sample is used for analysis. Results help inform treatment strategies like supplements, dietary changes, or further testing to restore energy balance and support mitochondrial health.

"Pyruvate" test evaluates pyruvate levels in your blood, a key compound involved in converting food into usable energy. Doctors may recommend this test when symptoms like chronic fatigue, muscle weakness, or neurological changes suggest a mitochondrial or metabolic issue. These imbalances can reflect impaired cellular energy production or signal underlying lactic acidosis. A blood sample is used for analysis. Results help inform treatment strategies like supplements, dietary changes, or further testing to restore energy balance and support mitochondrial health.

Category

Metabolites

Procedure

Invasive

Sample Type

Blood – Serum

Units

Milligrams Per Deciliter

Procedure Category

Blood Draw

Test Group

Mitochondrial Function Group

Test Group Description

Mitochondrial Function Group: This group evaluates various aspects of mitochondrial health and function, offering insights into cellular energy metabolism and potential mitochondrial disorders.

Optimal Range

For All Individuals:

  • Conventional Unit: 1.20–2.00 mg/dL

  • SI Unit: 0.13–0.22 mmol/L

Normal Range

For All Individuals:

  • Conventional Unit: 1.00–2.50 mg/dL

  • SI Unit: 0.11–0.28 mmol/L

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Acute liver disease (Rapid onset liver dysfunction)

  • Alcoholism

  • Chronic liver disease (Long-term liver dysfunction)

  • Disorders of gluconeogenesis (Defects in glucose synthesis pathway)

  • Pyruvate dehydrogenase deficiency (Genetic disorder affecting the enzyme responsible for converting pyruvate into acetyl-CoA)

  • ...

Key Reasons For Testing

  • Energy Metabolism: Assesses its role as a glycolytic intermediate in ATP production and respiration.

  • Diagnostic Marker: Identifies metabolic disorders like pyruvate dehydrogenase deficiency and mitochondrial diseases.

  • Lactate Production: Provides insights into lactate metabolism, acid-base balance, and lactic acidosis.

  • Gluconeogenesis: Evaluates its role as a precursor in glucose synthesis during fasting or high energy demand.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Robinson BH, Taylor J, Sherwood WG. The relationship between the lactate/pyruvate ratio in blood and cerebrospinal fluid in disorders of mitochondrial metabolism. J Inherit Metab Dis.1985;8(2):119-124.

[2] Stacpoole PW. The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases. Aging Cell. 2012;11(3):371-377.

[3] Labay V, Barbosa E, Mir C, et al. Clinical and biochemical studies in mitochondrial diseases caused by defects in pyruvate metabolism. Biochem Biophys Res Commun. 2005;328(3):751-756.

[4] Koene S, Wortmann SB, van de Heuvel L, et al. Pyruvate therapy for mitochondrial disease. Mol Genet Metab. 2013;109(4):379-381.

[5] DiMauro S, Schon EA. Mitochondrial respiratory-chain diseases. N Engl J Med.2003;348(26):2656-2668.

[6] Saengsirisuwan V, Perez FR, Sloniger JA, et al. Modulation of insulin resistance in skeletal muscle by the pyruvate dehydrogenase complex. Diabetes. 2004;53(4):928-934.

[7] McCormack JG, Denton RM. Role of mitochondrial calcium transport and matrix calcium in signal transduction in mammalian cells. Biochim Biophys Acta. 1993;1141(3):215-234.

[8] Timmons JA, Sundberg CJ, Larsson O, et al. Molecular adaptations to endurance exercise in skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2005;289(5).

[9] Schon EA, Przedborski S. Mitochondria: the next (neurode)generation. Neuron. 2011;70(6):1033-1053.

[10] Patel MS, Korotchkina LG. Regulation of pyruvate dehydrogenase complex. Biochem Soc Trans.2006;34(Pt 2):217-222.

[11] Haas RH, Parikh S, Falk MJ, et al. The in-depth clinical application of lactate and pyruvate measurements in mitochondrial disease. Genet Med. 2008;10(6):404-408.

[12] Veech RL, Chance B, Kashiwaya Y, et al. Ketone bodies, potential therapeutic uses. IUBMB Life.2001;51(4):241-247.

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