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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Reticulocyte Hemoglobin

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RET HE

Description

"Reticulocyte Relative" test calculates the percentage of new red blood cells compared to the total red blood cell count. It’s commonly ordered to assess bone marrow response in cases of anemia, blood loss, or marrow dysfunction. Elevated percentages may indicate active red blood cell production, while low results suggest impaired marrow activity. This test helps doctors determine the stage of recovery or disease progression. Regular tracking supports treatment planning and ensures red cell production remains on track.

"Reticulocyte Relative" test calculates the percentage of new red blood cells compared to the total red blood cell count. It’s commonly ordered to assess bone marrow response in cases of anemia, blood loss, or marrow dysfunction. Elevated percentages may indicate active red blood cell production, while low results suggest impaired marrow activity. This test helps doctors determine the stage of recovery or disease progression. Regular tracking supports treatment planning and ensures red cell production remains on track.

Category

Blood Cells

Procedure

Invasive

Sample Type

Blood – Whole Blood

Units

Picograms

Procedure Category

Blood Draw

Test Group

Hematology Group, Blood Count Complementary Group

Test Group Description

Blood Count Complementary Group: This set of tests supplements basic blood count assessments, providing additional information to further characterize blood cell composition and identify potential abnormalities. Hematology Group: Tests within this group focus on evaluating various aspects of blood health and function. These assessments provide insights into red blood cells, white blood cells, platelets, and other components of the blood.

Optimal Range

For All Individuals:

  • Conventional Unit: 30.00–36.00 pg

  • SI Unit: 30.00–36.00 pg

Normal Range

For All Individuals:

  • Conventional Unit: 28.0–35.0 pg

  • SI Unit: 28.0–35.0 pg

Results That Differ From The Norm (Direct and Indirect Causes)

Decreased levels may indicate:


  • Alcoholic liver disease (Liver damage due to excessive alcohol consumption)

  • Aplastic anemia (Bone marrow failure resulting in decreased red blood cell production)

  • Celiac disease (Autoimmune disorder affecting the small intestine)

  • Chronic kidney disease

  • Chronic liver disease

  • Crohn's disease...

Key Reasons For Testing

  • Iron Deficiency Assessment: Measures hemoglobin content in reticulocytes to diagnose and manage iron deficiency anemia.

  • Erythropoiesis Evaluation: Reflects the hemoglobinization status of new red blood cells, providing insights into bone marrow function.

  • Anemia Differentiation: Differentiates iron deficiency anemia from other causes of microcytic anemia based on hemoglobinization.

  • Treatment Monitoring: Tracks response to iron therapy or erythropoiesis-stimulating agents, guiding treatment adjustments.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Brugnara C, Schiller B, Moran J. Reticulocyte hemoglobin equivalent (Ret He) and assessment of iron-deficient states. Clin Lab Haematol. 2006;28(5):303-308.

[2] Thomas C, Thomas L. Anemia diagnosis: Ret He as a diagnostic marker for iron deficiency and iron-deficient erythropoiesis. Clin Chem Lab Med. 2002;40(12):1233-1237.

[3] Mast AE, Blinder MA, Lu Q, et al. Reticulocyte hemoglobin content as a diagnostic tool for iron deficiency. Am J Hematol. 2002;72(2):139-143.

[4] Lorenz LB, Wildes TM, Mathias M, et al. Diagnostic utility of reticulocyte hemoglobin content in patients with cancer-associated anemia. J Oncol Pract. 2018;14(10):588-596.

[5] Brugnara C. Reticulocyte hemoglobin equivalent in the evaluation of iron status and erythropoiesis. Curr Opin Hematol. 2013;20(3):172-177.

[6] Ullrich C, Wu A, Armsby C, et al. Reticulocyte hemoglobin content as a marker of iron-deficient erythropoiesis in children. JAMA. 2005;293(8):927-935.

[7] Piva E, Brugnara C, Spolaore F, et al. Clinical utility of reticulocyte hemoglobin in the diagnosis of iron-deficiency anemia. Clin Chem Lab Med. 2006;44(12):1424-1429.

[8] Thomas C, Thomas L. Biochemical markers and reticulocyte indices in the diagnosis of functional iron deficiency. Clin Chem Lab Med. 2006;44(8):940-949.

[9] Brugnara C. Use of reticulocyte hemoglobin content in the diagnosis of iron-deficient states. Curr Opin Hematol. 1998;5(2):132-136.

[10] Joosten E, Lioen P, Vermeersch P, et al. Reticulocyte hemoglobin equivalent in the diagnosis of iron deficiency in elderly hospitalized patients. Clin Chem Lab Med. 2013;51(3):583-589.

[11] D’Angelo G, Rogowski M, Reilly R. Anemia diagnostics: utility of Ret He in chronic kidney disease. Kidney Int Rep. 2021;6(5):1234-1241.

[12] Hoffmann JJ, Urrechaga E, Aguirre U. Reticulocyte and erythrocyte indices in the evaluation of iron status in chronic kidney disease. Clin Chim Acta. 2012;413(17-18):1498-1500.

[13] Munoz M, Gomez-Ramirez S, Campos A, et al. Role of reticulocyte hemoglobin content in the detection of iron deficiency. Anemia. 2017;2017:1093454.

[14] Mast AE, Blinder MA, Gronowski AM, et al. Reticulocyte hemoglobin content in the diagnosis of iron-deficient states in the setting of inflammation. Am J Hematol. 2008;83(10):848-852.

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