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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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S-Adenosylhomocysteine

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SAH

Description

"S-Adenosylhomocysteine" (SAH) test checks how efficiently your body is processing methylation reactions linked to heart and metabolic health. Elevated SAH levels may signal increased cardiovascular risk, oxidative stress, or poor B-vitamin status. Doctors may recommend this test when patients experience fatigue, inflammation, or neurological symptoms. A simple blood draw provides insight into metabolic performance. Results help tailor care using targeted nutrients or lifestyle changes to rebalance methylation and support long-term cardiovascular and cellular function.

"S-Adenosylhomocysteine" (SAH) test checks how efficiently your body is processing methylation reactions linked to heart and metabolic health. Elevated SAH levels may signal increased cardiovascular risk, oxidative stress, or poor B-vitamin status. Doctors may recommend this test when patients experience fatigue, inflammation, or neurological symptoms. A simple blood draw provides insight into metabolic performance. Results help tailor care using targeted nutrients or lifestyle changes to rebalance methylation and support long-term cardiovascular and cellular function.

Category

Amino Acids, Metabolites

Procedure

Invasive

Sample Type

Blood – Plasma

Units

Nanomoles Per Liter

Procedure Category

Blood Draw

Test Group

Methylation Group

Test Group Description

Methylation Group: Centered on evaluating methylation levels and associated parameters, this group provides insights into methylation processes and their related health implications.

Optimal Range

For All Individuals:

  • Conventional Unit: Not Available

  • SI Unit: Not Applicable

Normal Range

For All Individuals:

  • Conventional Unit: 10.00–22.00 nmol/L

  • SI Unit: 10.00–22.00 nmol/L

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Alcoholism (Excessive alcohol consumption)

  • Cardiovascular disease (Disorders affecting the heart and blood vessels)

  • Chronic kidney disease (Progressive loss of kidney function)

  • Chronic stress (Prolonged exposure to stressful situations)

  • Depression (Mood disorder characterized by persistent sadness and loss of interest or ...

Key Reasons For Testing

  • Epigenetic Regulation: Influences methylation and gene expression, impacting cellular function and disease processes.

  • Methylation Potential Indicator: Reflects methyl group availability and enzyme activity, offering insights into cellular methylation status.

  • Cardiovascular Disease Risk: Serves as a biomarker for predicting cardiovascular events such as heart attacks and strokes.

  • Liver Dysfunction Marker: Indicates liver injury and metabolic disturbances, aiding in diagnosing and managing liver diseases like hepatitis or cirrhosis.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Cantoni GL. The role of S-adenosylhomocysteine in the biological utilization of S-methylmethionine. J Biol Chem. 1953;204(1):403-416.

[2] Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. 1990;1(5):228-237.

[3] Ueland PM. S-Adenosylhomocysteine: a biological marker of the methylation potential. Acta Biochim Pol. 1989;36(1):227-234.

[4] Lu SC, Mato JM. S-adenosylmethionine in cell growth, apoptosis and liver cancer. J Gastroenterol Hepatol. 2008;23(Suppl 1).

[5] Yi P, Melnyk S, Pogribna M, et al. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem. 2000;275(38):29318-29323.

[6] James SJ, Melnyk S, Pogribna M, et al. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr. 2002;132(8 Suppl):2361S-2366S.

[7] Struys EA, Jansen EE, de Meer K, et al. Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry. Clin Chem. 2000;46(10):1650-1656.

[8] Castro R, Rivera I, Blom HJ, et al. Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview. J Inherit Metab Dis. 2006;29(1):3-20.

[9] Mudd SH, Finkelstein JD, Refsum H, et al. Homocysteine and its disulfide derivatives: a suggested consensus terminology. J Inherit Metab Dis. 2000;23(3):263-270.

[10] Stabler SP, Marcell PD, Podell ER, et al. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J Clin Invest. 1988;81(2):466-474.

[11] Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999;19:217-246.

[12] Refsum H, Ueland PM, Nygård O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med. 1998;49:31-62.

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