Small Dense Low-Density Lipoprotein Cholesterol
SDLDL C
Description
"Small Dense Low-Density Lipoprotein (sdLDL) Cholesterol" test identifies the amount of compact sdLDL particles in your blood, which are more likely to penetrate artery walls and promote plaque buildup. Elevated levels are linked to increased heart disease risk. This test is especially helpful for individuals with diabetes, high triglycerides, or a strong family history of cardiovascular issues. Results inform care strategies such as dietary changes, medications, or exercise plans. Ongoing monitoring helps support cardiovascular protection and lower long-term risk.
Category
Lipids, Proteins
Procedure
Invasive
Sample Type
Blood – Serum
Units
Milligrams Per Deciliter | Millimoles Per Liter
Procedure Category
Blood Draw
Test Group
Basic Cardiovascular Group, Complete Cardiovascular Group, Complete Lipid Group, Cardio Risk Group
Test Group Description
Basic Cardiovascular Group: This group includes fundamental tests targeting essential markers related to cardiovascular health, providing foundational insights into cholesterol levels, blood pressure, and other key factors. Cardio Risk Group: This group focuses on assessing various markers associated with cardiovascular health and risk factors, aiding in the early detection and management of cardiovascular diseases. Complete Cardiovascular Group: This group contains comprehensive tests for an extensive evaluation of cardiovascular health, providing thorough insights into heart-related conditions beyond basic assessments. Complete Lipid Group: Extensive tests offer a comprehensive evaluation of lipid levels, providing detailed insights into cholesterol and triglyceride profiles and their implications for cardiovascular health.
Optimal Range
For All Individuals:
Conventional Unit: 1–36 mg/dL
SI Unit: 0.026–0.93 mmol/L
Normal Range
For All Individuals:
Conventional Unit: <50 mg/dL
SI Unit: <1.3 mmol/L
Results That Differ From The Norm (Direct and Indirect Causes)
Increased levels may indicate:
Alcoholism
Chronic kidney disease
Chronic obstructive pulmonary disease (Chronic lung disease)
Crohn's disease (Chronic inflammatory bowel disease)
Familial hypercholesterolemia (Inherited high cholesterol)
High carbohydrate intake
High transfats intake
...
Key Reasons For Testing
Cardiovascular Risk Assessment: Identifies individuals at higher risk of coronary artery disease due to atherogenic small dense LDL particles.
Dyslipidemia Evaluation: Detects elevated sdLDL-C in individuals with normal LDL-C levels, providing deeper risk insights.
Diabetes Management: Highlights increased cardiovascular risk in diabetic patients, guiding lipid-lowering therapies.
Response to Lipid-Lowering Therapy: Monitors sdLDL-C reductions to evaluate treatment effectiveness and cardiovascular risk improvement.
Health Status Conditions It May Be Used To Assess
Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.
Some Prominent Medical Labs That May Offer This Test
Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.
References
Important Note
Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.
Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.
Disclaimer
This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.
Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.
[1] Austin MA, King MC, Vranizan KM, Krauss RM. Atherogenic lipoprotein phenotype: a proposed genetic marker for coronary heart disease risk. Circulation. 1990;82(2):495-506.
[2] Hoogeveen RC, Gaubatz JW, Sun W, et al. Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. Arterioscler Thromb Vasc Biol. 2014;34(5):1069-1077.
[3] Hirano T, Ito Y, Saegusa H, et al. A novel and simple method for quantification of small, dense LDL. J Lipid Res. 2003;44(11):2193-2201.
[4] Ikezaki H, Lim E, Cupples LA, et al. Small dense low-density lipoprotein cholesterol is the most atherogenic lipoprotein parameter in the prospective Framingham Offspring Study. J Am Heart Assoc. 2021;10(5).
[5] Krauss RM. Lipoprotein subfractions and cardiovascular disease risk. Curr Opin Lipidol. 2010;21(4):305-311.
[6] Ito Y, Fujimura M, Ohta M, et al. Development of a homogeneous assay for measurement of small dense LDL cholesterol. Clin Chem. 2011;57(1):57-65.
[7] Koba S, Hirano T, Ito Y, et al. Significance of small dense LDL cholesterol levels as a risk factor for coronary heart disease in the Japanese population. Atherosclerosis. 2002;160(1):187-194.
[8] Cheung MC, Brown BG, Wolf AC, Albers JJ. Altered particle size distribution of apolipoprotein B-containing lipoproteins in subjects with coronary artery disease. J Lipid Res. 1991;32(3):383-394.
[9] Liou L, Kaptoge S. Association of small, dense LDL-cholesterol concentration and lipoprotein particle characteristics with coronary heart disease: A systematic review and meta-analysis. PLoS One. 2020;15(11).
[10] Tsai MY, Steffen BT, Guan W, et al. New automated assay of small dense low-density lipoprotein cholesterol identifies risk of coronary heart disease: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34(1):196-201.
[11] Williams PT, Krauss RM. VLDL remnants, IDL, and LDL subclasses in the atherogenic dyslipidemia of obesity. Arterioscler Thromb Vasc Biol. 2005;25(8):1696-1704.
[12] Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;73(24).