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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Small Dense Low-Density Lipoprotein Particle Number

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SDLDL P

Description

"Small Dense Low-Density Lipoprotein (sdLDL) Particle Number" test measures how many smaller, denser LDL particles are circulating in your blood. These particles are more likely to contribute to atherosclerosis, making this test useful for assessing cardiovascular risk. It’s especially important for people with high cholesterol, diabetes, or a family history of heart disease. A higher sdLDL count may prompt treatment. Based on results, your doctor may suggest diet changes, exercise, or medications. Regular tracking helps reduce heart disease risk.

"Small Dense Low-Density Lipoprotein (sdLDL) Particle Number" test measures how many smaller, denser LDL particles are circulating in your blood. These particles are more likely to contribute to atherosclerosis, making this test useful for assessing cardiovascular risk. It’s especially important for people with high cholesterol, diabetes, or a family history of heart disease. A higher sdLDL count may prompt treatment. Based on results, your doctor may suggest diet changes, exercise, or medications. Regular tracking helps reduce heart disease risk.

Category

Lipids, Proteins

Procedure

Invasive

Sample Type

Blood – Serum

Units

Nanomoles Per Liter | Micromoles Per Liter

Procedure Category

Blood Draw

Test Group

Complete Cardiovascular Group, Lipoprotein Fractionation Group

Test Group Description

Complete Cardiovascular Group: This group contains comprehensive tests for an extensive evaluation of cardiovascular health, providing thorough insights into heart-related conditions beyond basic assessments. Lipoprotein Fractionation Group: Analyzes lipoprotein fractions through NMR technology, providing detailed insights into lipid metabolism and cardiovascular health.

Optimal Range

For All Individuals:

  • Conventional Unit: <467 nmol/L

  • SI Unit: <0.467 µmol/L

Normal Range

For All Individuals:

  • Conventional Unit: <1200 nmol/L

  • SI Unit: <1.2 µmol/L

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Chronic kidney disease

  • Familial hypercholesterolemia (Inherited high cholesterol)

  • High carbohydrate intake

  • High transfats intake

  • Insulin resistance (Reduced responsiveness to insulin)

  • Metabolic syndrome (Cluster of conditions including high blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol levels)

  • Obesity

  • Smoking

  • Type 2 diabetes (Metabolic disorder characterized by high blood sugar levels)

Key Reasons For Testing

  • Cardiovascular Risk Assessment: Measures atherogenic sdLDL particles, aiding in risk evaluation and treatment planning.

  • Advanced Lipid Profile: Refines cardiovascular risk prediction by assessing lipid particle size and composition.

  • Dyslipidemia Evaluation: Detects elevated cardiovascular risk in individuals with normal LDL-C but high sdLDL-P.

  • Diabetes Management: Highlights cardiovascular risks in diabetes, supporting tailored lipid-lowering strategies.

  • Response to Lipid-Lowering Therapy: Tracks reductions in sdLDL-P to evaluate treatment effectiveness.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Hoogeveen RC, Gaubatz JW, Sun W, et al. Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. Arterioscler Thromb Vasc Biol. 2014;34(5):1069-1077.

[2] Ikezaki H, Lim E, Cupples LA, et al. Small dense low-density lipoprotein cholesterol is the most atherogenic lipoprotein parameter in the prospective Framingham Offspring Study. J Am Heart Assoc. 2021;10(5):e019140.

[3] Liou L, Kaptoge S. Association of small, dense LDL-cholesterol concentration and lipoprotein particle characteristics with coronary heart disease: A systematic review and meta-analysis. PLoS One. 2020;15(11):e0241993.

[4] Berneis KK, Krauss RM. Metabolic origins and clinical significance of LDL heterogeneity. J Lipid Res. 2002;43(9):1363-1379.

[5] Tsai MY, Steffen BT, Guan W, et al. New automated assay of small dense low-density lipoprotein cholesterol identifies risk of coronary heart disease: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34(1):196-201.

[6] Cheung MC, Brown BG, Wolf AC, Albers JJ. Altered particle size distribution of apolipoprotein B-containing lipoproteins in subjects with coronary artery disease. J Lipid Res. 1991;32(3):383-394.

[7] Krauss RM. Lipoprotein subfractions and cardiovascular disease risk. Curr Opin Lipidol. 2010;21(4):305-311.

[8] Williams PT, Krauss RM. VLDL remnants, IDL, and LDL subclasses in the atherogenic dyslipidemia of obesity. Arterioscler Thromb Vasc Biol. 2005;25(8):1696-1704.

[9] Hovingh GK, Boekholdt SM, Mora S, et al. LDL particle number and small dense LDL: implications for cardiovascular risk assessment. Curr Opin Lipidol. 2015;26(6):636-643.

[10] Toth PP, Granowitz C, Hull M, et al. High levels of small dense low-density lipoprotein cholesterol in hypertriglyceridemia: results of the National Health and Nutrition Examination Survey. J Clin Lipidol. 2007;1(6):469-476.

[11] Rizzo M, Berneis K. Low-density lipoprotein size and cardiovascular risk assessment. QJM. 2006;99(1):1-14.

[12] Sniderman AD, Williams K, Contois JH, et al. A meta-analysis of low-density lipoprotein particle number and cardiovascular risk. J Clin Lipidol. 2014;8(2):207-213.

[13] Otvos JD, Mora S, Shalaurova I, et al. Clinical implications of discordance between low-density lipoprotein cholesterol and particle number. J Clin Lipidol. 2011;5(2):105-113.

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