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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Total Iron Binding Capacity

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TIBC

Description

"Total Iron-Binding Capacity" (TIBC) test measures your blood’s ability to bind and carry iron, helping assess overall iron metabolism. It’s often used to diagnose iron deficiency anemia or identify conditions linked to iron overload. A blood sample is analyzed to determine if the body is transporting iron efficiently. High TIBC may point to low iron, while low TIBC can suggest excess iron or chronic disease. Doctors use results to confirm diagnosis and tailor treatment approaches.

"Total Iron-Binding Capacity" (TIBC) test measures your blood’s ability to bind and carry iron, helping assess overall iron metabolism. It’s often used to diagnose iron deficiency anemia or identify conditions linked to iron overload. A blood sample is analyzed to determine if the body is transporting iron efficiently. High TIBC may point to low iron, while low TIBC can suggest excess iron or chronic disease. Doctors use results to confirm diagnosis and tailor treatment approaches.

Category

Minerals

Procedure

Invasive

Sample Type

Blood – Serum

Units

Micrograms per Deciliter | Micromoles per Liter

Procedure Category

Blood Draw

Test Group

Iron Group, Basic Nutrient Deficiency Group, Complete Nutrient Deficiency Group

Test Group Description

Basic Nutrient Deficiency Group: This group comprises essential tests aimed at assessing key nutrient levels vital for overall health and well-being. Complete Nutrient Deficiency Group: This comprehensive group includes an expanded panel of tests covering a wide range of vitamins, minerals, and other essential nutrients. Iron Group: Its focus lies on evaluating iron levels and related parameters, offering insights into iron metabolism and associated health conditions. 

Optimal Range

For All Individuals:

  • Conventional Unit: 250–400 µg/dL

  • SI Unit: 44.8–71.6 µmol/L

Normal Range

For All Individuals:

  • Conventional Unit: 240–450 µg/dL

  • SI Unit: 42.9–80.5 µmol/L

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Crohn's disease (Inflammatory bowel disease affecting the gastrointestinal tract)

  • Hemochromatosis (early stages) (Iron overload disorder characterized by excessive absorption of dietary iron)

  • Hypoalbuminemia (Low levels of albumin protein in the blood)

  • Iron deficiency anemia (Anemia caused by insufficient iron levels in the body)

  • ...

Key Reasons For Testing

  • Anemia Evaluation: TIBC evaluates the body’s ability to bind and transport iron, aiding anemia assessment.

  • Iron Deficiency Diagnosis: Elevated TIBC levels indicate iron deficiency anemia, guiding diagnosis and treatment.

  • Iron Overload Monitoring: Detects conditions like hemochromatosis with excess iron accumulation.

  • Assessment of Iron Status: Used with other markers to evaluate iron levels and metabolism.

  • Differential Diagnosis: Helps distinguish between anemia types, such as iron deficiency and chronic disease.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Yamanishi H, Iyama S, Yamaguchi Y, Kanakura Y, Iwatani Y. Total iron-binding capacity calculated from serum transferrin concentration or serum iron concentration and unsaturated iron-binding capacity. Clin Chem. 2003;49(1):175-178.

[2] Kasvosve I, Delanghe J. Total iron binding capacity and transferrin concentration in the assessment of iron status. Clin Chem Lab Med. 2002;40(10):1014-1018.

[3] Gambino R, Desvarieux E, Orth M, et al. The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferrin concentrations in human serum. Clin Chem. 1997;43(12):2408-2412.

[4] Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood. 2003;101(9):3359-3364.

[5] Suominen P, Punnonen K, Rajamäki A, Irjala K. Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits. Blood. 1998;92(8):2934-2939.

[6] Skikne BS, Flowers CH, Cook JD. Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood. 1990;75(9):1870-1876.

[7] Punnonen K, Irjala K, Rajamäki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood. 1997;89(3):1052-1057.

[8] Suominen P, Punnonen K, Rajamäki A, Irjala K. Evaluation of new immunoenzymometric assay for measuring soluble transferrin receptor to detect iron deficiency. Clin Chem. 1997;43(9):1641-1646.

[9] Baynes RD. Assessment of iron status. Clin Biochem. 1996;29(3):209-215.

[10] Cook JD, Skikne BS, Baynes RD. Serum transferrin receptor. Annu Rev Med. 1993;44:63-74.

[11] Gropper SS, Smith JL, Carr TP. Advanced Nutrition and Human Metabolism. 7th ed. Cengage Learning. 2018.

[12] Guyatt GH, Oxman AD, Ali M, et al. Laboratory diagnosis of iron-deficiency anemia: an overview. J Gen Intern Med. 1992;7(2):145-153.

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