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Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Tuberculosis Blood

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TBB

Description

"Tuberculosis Blood" test evaluates how your immune system responds to Mycobacterium tuberculosis, the bacteria that cause TB. It’s often used when skin testing isn’t suitable or a more precise result is needed. The test measures interferon-gamma release in response to TB antigens. A positive result indicates exposure and may require follow-up imaging or testing. This blood test supports TB screening in high-risk individuals and helps guide timely treatment to prevent progression or spread.

"Tuberculosis Blood" test evaluates how your immune system responds to Mycobacterium tuberculosis, the bacteria that cause TB. It’s often used when skin testing isn’t suitable or a more precise result is needed. The test measures interferon-gamma release in response to TB antigens. A positive result indicates exposure and may require follow-up imaging or testing. This blood test supports TB screening in high-risk individuals and helps guide timely treatment to prevent progression or spread.

Category

Microbes

Procedure

Invasive

Sample Type

Blood – Serum

Units

International Units Per Milliliter

Procedure Category

Blood Draw

Test Group

Microbial Assessment Group, Infection Group

Test Group Description

Microbial Assessment Group: Tests in this group analyze microbial presence and activity in various samples, offering insights into microbial populations and their impact on health. They help identify specific microorganisms, assess microbial diversity, and evaluate microbial functions in different environments. Infection Group: Tests within this group detect markers indicative of various infections, aiding in the diagnosis and management of infectious diseases.

Optimal Range

For All Individuals:

  • Conventional Unit: TB-Nil: Not Available | Interpretation: Not Available

  • SI Unit: Not Applicable

Normal Range

For All Individuals:

  • Conventional Unit: TB-Nil: <0.35 IU/mL | Interpretation: ≤4 Spots (Negative)

  • SI Unit: Not Applicable

Results That Differ From The Norm (Direct and Indirect Causes)

Abnormal results may indicate:


  • Acquired immunodeficiency syndrome (Advanced stage of HIV infection characterized by severe immune system suppression)

  • Active tuberculosis infection (Presence of active Mycobacterium tuberculosis in the body)

  • Human Immunodeficiency Virus (Virus causing immunodeficiency)

  • Latent tuberculosis infection (Presence of dormant Mycobacterium tuberculosis in the body)

  • ...

Key Reasons For Testing

  • Active Tuberculosis Diagnosis: Detects antibodies or antigens to confirm active tuberculosis infection.

  • Latent Tuberculosis Screening: Identifies individuals exposed to TB bacteria without active disease.

  • Drug-Resistant Tuberculosis Management: Detects drug-resistant strains to guide effective treatment.

  • Testing for Immunocompromised Patients: Essential for HIV/AIDS patients or immunosuppressed individuals at higher TB risk.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Pai M, Denkinger CM, Kik SV, et al. Gamma Interferon Release Assays for Detection of Mycobacterium tuberculosis Infection. Clin Microbiol Rev. 2014;27(1):3-20.

[2] Mazurek GH, Jereb J, LoBue P, et al. Guidelines for Using the QuantiFERON-TB Test for Diagnosing Latent Mycobacterium tuberculosis Infection. MMWR Recomm Rep. 2005;54(RR-15):49-55.

[3] Lewinsohn DM, Leonard MK, LoBue PA, et al. Official ATS/IDSA/CDC Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children. Clin Infect Dis. 2017;64(2).

[4] Rangaka MX, Wilkinson KA, Glynn JR, et al. Predictive Value of Interferon-γ Release Assays for Incident Active Tuberculosis: A Systematic Review and Meta-Analysis. Lancet Infect Dis. 2012;12(1):45-55.

[5] Menzies D, Pai M, Comstock G. New Tests for the Diagnosis of Latent Tuberculosis Infection: Areas of Uncertainty and Recommendations for Research. Ann Intern Med. 2007;146(5):340-354.

[6] Diel R, Loddenkemper R, Nienhaus A. Evidence-Based Comparison of Commercial Interferon-Gamma Release Assays for Detecting Active Tuberculosis: A Meta-Analysis. Chest. 2010;137(4):952-968.

[7] Metcalfe JZ, Everett CK, Steingart KR, et al. Interferon-Gamma Release Assays for Active Pulmonary Tuberculosis Diagnosis in Adults in Low- and Middle-Income Countries: Systematic Review and Meta-Analysis. J Infect Dis. 2011;204(Suppl 4).

[8] Banaei N, Gaur RL, Pai M. Interferon-Gamma Release Assays for Latent Tuberculosis: What Are the Sources of Variability? J Clin Microbiol. 2016;54(4):845-850.

[9] World Health Organization. Use of Interferon-Gamma Release Assays (IGRAs) in Tuberculosis Control in Low- and Middle-Income Countries. Geneva: WHO; 2011.

[10] Mori T, Sakatani M, Yamagishi F, et al. Specific Detection of Tuberculosis Infection: An Interferon-Gamma-Based Assay Using New Antigens. Am J Respir Crit Care Med. 2004;170(1):59-64.

[11] Sester M, Sotgiu G, Lange C, et al. Interferon-γ Release Assays for the Diagnosis of Active Tuberculosis: A Systematic Review and Meta-Analysis. Eur Respir J. 2011;37(1):100-111.

[12] Huebner RE, Schein MF, Bass JB Jr. The Tuberculin Skin Test and Newer Tuberculosis Screening Methods. Clin Infect Dis. 1993;17(6):968-975.

[13] Farhat M, Greenaway C, Pai M, Menzies D. False-Positive Tuberculin Skin Tests: What Is the Absolute Effect of BCG and Non-Tuberculous Mycobacteria? Int J Tuberc Lung Dis. 2006;10(11):1192-1204.

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