
Tumor Necrosis Factor Alpha

TNF A
Description
"Tumor Necrosis Factor Alpha" (TNF-α) test measures levels of TNF-α, an inflammatory protein involved in immune regulation and chronic disease. Doctors often order this test when autoimmune conditions, persistent inflammation, or infections are suspected. Elevated TNF-α may indicate diseases like rheumatoid arthritis, IBD, or systemic inflammation. A blood sample is used to assess activity. Results help guide treatment plans, including immunosuppressive therapies or monitoring response. Ongoing testing supports inflammation control and long-term immune system management.
Category
Cytokines, Inflammatory Markers
Procedure
Invasive
Sample Type
Blood – Plasma
Units
Picograms Per Milliliter
Procedure Category
Blood Draw
Test Group
Complete Inflammation Group, Immune System Group
Test Group Description
Complete Inflammation Group: Extensive tests offer a comprehensive assessment of inflammatory markers, yielding detailed insights into inflammation levels and related health conditions. Immune System Group: By evaluating various aspects of immune system function and health, this group offers insights into immune responses and related health considerations.
Optimal Range
For All Individuals:
Conventional Unit: Not Available
SI Unit: Not Available
Normal Range
For All Individuals:
Conventional Unit: 0.00–2.20 pg/mL
SI Unit: Not Applicable
Results That Differ From The Norm (Direct and Indirect Causes)
Abnormal results may indicate:
Ankylosing spondylitis (Inflammatory arthritis affecting the spine and large joints)
Alzheimer's disease (Neurodegenerative disorder affecting memory and cognitive function)
Autoimmune hepatitis (Liver inflammation due to autoimmune response)
Cancer
Chronic stress
Crohn's disease (Inflammatory bowel diseas...
Key Reasons For Testing
Inflammation Marker: Diagnoses and monitors inflammatory conditions like rheumatoid arthritis and inflammatory bowel disease.
Autoimmune Disease Evaluation: Detects elevated TNF-alpha levels associated with autoimmune diseases, aiding in management.
Sepsis Diagnosis: Identifies elevated TNF-alpha levels in sepsis, aiding in diagnosis and severity assessment.
Therapeutic Target: Guides treatment and monitoring in conditions treated with TNF-alpha inhibitors.
Diagnostic Tool: Enhances accuracy in diagnosing infectious, autoimmune, and inflammatory diseases.
Health Status Conditions It May Be Used To Assess
Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.
Some Prominent Medical Labs That May Offer This Test
Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.
References
Important Note
Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.
Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.
Disclaimer
This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.
Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.
[1] Beutler B, Cerami A. Tumor Necrosis Factor: The Molecule and Its Role in Inflammatory Disease. Annu Rev Immunol. 1989;7(1):625-655.
[2] Balkwill F. Tumor Necrosis Factor or Tumor Promoting Factor? Cytokine Growth Factor Rev. 2002;13(2):135-141.
[3] Chen G, Goeddel DV. TNF-R1 Signaling: A Beautiful Pathway. Science. 2002;296(5573):1634-1635.
[4] Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology. Cell. 2001;104(4):487-501.
[5] Tracey KJ, Cerami A. Tumor Necrosis Factor, Other Cytokines and Disease. Annu Rev Cell Biol. 1993;9(1):317-343.
[6] Tracey KJ, Wei H, Manogue KR, et al. Cachectin/TNF Induces Cachexia, Anorexia, and Inflammation. J Exp Med. 1988;167(3):1211-1227.
[7] Bradley JR. TNF-Mediated Inflammatory Disease. J Pathol. 2008;214(2):149-160.
[8] Lien E, Aukrust P, Sundre AT, et al. Elevated Levels of Tumor Necrosis Factor-α in Serum from Patients with HIV Infection Correlate with Markers of Immune Activation. Clin Immunol Immunopathol. 1998;87(2):196-202.
[9] Aggarwal BB. Tumor Necrosis Factor Receptor Associated Signaling Molecules and Their Role in TNF-α Mediated Cell Death. J Clin Immunol. 1999;19(6):330-343.
[10] Vassalli P. The Pathophysiology of Tumor Necrosis Factors. Annu Rev Immunol. 1992;10:411-452.
[11] Sherry B, Cerami A. Cachectin/Tumor Necrosis Factor Exerts Endocrine, Paracrine, and Autocrine Control of Inflammatory Responses. J Cell Biol. 1988;107(4):1269-1277.
[12] Carswell EA, Old LJ, Kassel RL, et al. An Endotoxin-Induced Serum Factor That Causes Necrosis of Tumors. Proc Natl Acad Sci USA. 1975;72(9):3666-3670.
[13] Kriegler M, Perez C, DeFay K, et al. A Novel Form of TNF/Cachectin Is a Cell Surface Cytotoxic Transmembrane Protein: Ramifications for the Complex Physiology of TNF. Cell. 1988;53(1):45-53.