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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Very Low-Density Lipoprotein Size

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VLDL S

Description

"Very Low-Density Lipoprotein (VLDL) Size" test evaluates the average size of VLDL particles to better understand your risk for heart disease and metabolic conditions. Smaller particles are more likely to enter artery walls and promote plaque buildup. Doctors may recommend this test if triglycerides are high or other risk factors are present. Results inform tailored strategies such as dietary changes, exercise, or medications. Monitoring VLDL size over time helps refine treatment and improve long-term cardiovascular outcomes.

"Very Low-Density Lipoprotein (VLDL) Size" test evaluates the average size of VLDL particles to better understand your risk for heart disease and metabolic conditions. Smaller particles are more likely to enter artery walls and promote plaque buildup. Doctors may recommend this test if triglycerides are high or other risk factors are present. Results inform tailored strategies such as dietary changes, exercise, or medications. Monitoring VLDL size over time helps refine treatment and improve long-term cardiovascular outcomes.

Category

Lipids, Proteins

Procedure

Invasive

Sample Type

Blood – Serum

Units

Nanometers

Procedure Category

Blood Draw

Test Group

Complete Cardiovascular Group, Lipoprotein Fractionation Group

Test Group Description

Complete Cardiovascular Group: This group contains comprehensive tests for an extensive evaluation of cardiovascular health, providing thorough insights into heart-related conditions beyond basic assessments. Lipoprotein Fractionation Group: Analyzes lipoprotein fractions through NMR technology, providing detailed insights into lipid metabolism and cardiovascular health.

Optimal Range

For All Individuals:

  • Conventional Unit: <47.10 nm

  • SI Unit: Not Applicable

Normal Range

For All Individuals:

  • Conventional Unit: 30–60 nm

  • SI Unit: Not Applicable

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Alcoholism

  • Alcoholic liver disease (Liver damage due to alcohol abuse)

  • Chronic kidney disease

  • Familial combined hyperlipidemia (Genetic disorder leading to larger VLDL particles)

  • High-refined carbohydrate diet

  • High trans-fat diet

  • Hypothyroidism (Underactive...

Key Reasons For Testing

  • Cardiovascular Risk Assessment: Smaller VLDL particles indicate higher risk of atherosclerosis and coronary artery disease.

  • Lipid Profile Evaluation: Smaller particles contribute to plaque formation, providing insights into lipid metabolism.

  • Metabolic Syndrome Assessment: Small, dense VLDL particles are linked to metabolic syndrome and its associated risks.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Packard CJ, Demant T, Stewart JP, et al. Apolipoprotein B Metabolism and the Determinants of Very Low-Density Lipoprotein Heterogeneity. Arterioscler Thromb Vasc Biol. 2000;20(2):413-420.

[2] Ginsberg HN. Is Lipoprotein Size Important? Circulation. 2001;104(10):1174-1175.

[3] Adiels M, Taskinen MR, Boren J. Fatty Liver, Insulin Resistance, and Dyslipidemia. Curr Diab Rep. 2008;8(1):60-64.

[4] Fisher EA, Feig JE, Hewing B, et al. High-Density Lipoprotein Function, Dysfunction, and Reverse Cholesterol Transport. Arterioscler Thromb Vasc Biol. 2012;32(12):2813-2820.

[5] Kotronen A, Yki-Järvinen H, Sevastianova K, et al. Comparison of Different Liver Fat Volume Indicators in the Association with Risk of Cardiovascular Disease: The Role of VLDL Size. Clin Endocrinol (Oxf). 2013;79(2):187-192.

[6] McKeone BJ, Patsch JR, Pownall HJ. Plasma Triglycerides Determine Lipoprotein Surface Properties. J Clin Invest. 1993;91(6):1926-1933.

[7] Chapman MJ, Ginsberg HN, Amarenco P, et al. Triglyceride-Rich Lipoproteins and High-Density Lipoprotein Cholesterol in Patients at High Risk of Cardiovascular Disease: Evidence and Guidance for Management. Eur Heart J. 2011;32(11):1345-1361.

[8] Watts GF, Barrett PH, Mamo JC, et al. Metabolic and Structural Heterogeneity in Very Low-Density Lipoproteins of Normolipidemic Subjects: Studies of Apolipoprotein B-100 Kinetics Using Stable Isotope Tracers. J Lipid Res. 1999;40(8):1601-1612.

[9] Couillard C, Bergeron N, Pascot A, et al. Evidence for Impaired Lipolysis in Abdominally Obese Men: A Factor Contributing to the Heterogeneity of VLDL Size. Int J Obes Relat Metab Disord. 2002;26(11):1359-1365.

[10] Sniderman AD, Thanassoulis G, Glavinovic T, et al. Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review. JAMA Cardiol. 2019;4(12):1287-1295.

[11] Griffin BA. Lipoprotein Size and Cardiovascular Risk: Small Dense LDL and Beyond. Curr Opin Lipidol. 2022;33(4):225-232.

[12] Musunuru K. Atherogenic Dyslipidemia: Cardiovascular Risk and Dietary Intervention. Lipidology. 2010;24(6):689-696.

[13] Ramasamy I. Recent Advances in Physiological Lipoprotein Metabolism. Clin Chem Lab Med. 2014;52(12):1695-1727.

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