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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Vitamin B12

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VIT B12

Description

"Vitamin B12" test measures vitamin B12 levels in your blood to detect deficiency and monitor metabolic health. Low levels can lead to fatigue, anemia, nerve damage, and cognitive decline. It’s recommended for individuals with symptoms like memory issues, numbness, or weakness. This test is especially important for older adults, vegetarians, or those with absorption problems. Results help guide treatment with diet changes, supplements, or injections. Regular monitoring of B12 supports nerve health, brain function, and red blood cell production.

"Vitamin B12" test measures vitamin B12 levels in your blood to detect deficiency and monitor metabolic health. Low levels can lead to fatigue, anemia, nerve damage, and cognitive decline. It’s recommended for individuals with symptoms like memory issues, numbness, or weakness. This test is especially important for older adults, vegetarians, or those with absorption problems. Results help guide treatment with diet changes, supplements, or injections. Regular monitoring of B12 supports nerve health, brain function, and red blood cell production.

Category

Vitamins

Procedure

Invasive

Sample Type

Blood – Serum

Units

Nanograms per Milliliter | Picomoles per Liter

Procedure Category

Blood Draw

Test Group

Vitamin Group, Cognitive Health Group, Basic Nutrient Deficiency Group, Complete Nutrient Deficiency Group

Test Group Description

Basic Nutrient Deficiency Group: This group comprises essential tests aimed at assessing key nutrient levels vital for overall health and well-being. Cognitive Health Group: This group of tailored tests is aimed at evaluating cognitive function and assessing markers related to cognitive health, providing valuable insights for cognitive well-being and potential cognitive disorders. Complete Nutrient Deficiency Group: This comprehensive group includes an expanded panel of tests covering a wide range of vitamins, minerals, and other essential nutrients. Vitamin Group: This collection of tests encompasses a range of key vitamins crucial for physiological functions, aiding in nutritional status evaluation and deficiency detection.

Optimal Range

For All Individuals:

  • Conventional Unit: 800–1200 pg/mL

  • SI Unit: 590–885 pmol/L

Normal Range

For All Individuals:

  • Conventional Unit: 232–1245 pg/mL

  • SI Unit: 172–919 pmol/L

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Chronic myeloid leukemia (Blood cancer)

  • Excessive B12 supplementation

  • Excessive B12-containing food intake

  • Functional B12 deficiency

  • Genetic factors

  • Hemolysis (Red blood cell destruction)

  • Kidney dysfunction

  • Medications (Cert...

Key Reasons For Testing

  • Neurological Health: Identifies deficiency to prevent or address neuropathy, cognitive impairment, and mood disturbances.

  • Anemia Diagnosis: Detects megaloblastic anemia caused by vitamin B12 deficiency.

  • Management of Pernicious Anemia: Guides treatment and monitoring for autoimmune-related B12 deficiency.

  • Evaluation of Malabsorption: Identifies absorption issues linked to gastrointestinal conditions or sur...

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Lindenbaum J, Savage DG, Stabler SP, Allen RH. Diagnosis of Cobalamin Deficiency: II. Relative Sensitivities of Serum Cobalamin, Methylmalonic Acid, and Total Homocysteine Concentrations. Am J Hematol. 1990;34(2):99-107.

[2] Stabler SP, Allen RH, Savage DG, Lindenbaum J. Clinical Spectrum and Diagnosis of Cobalamin Deficiency. Blood. 1990;76(5):871-881.

[3] Yetley EA, Pfeiffer CM, Phinney KW, et al. Biomarkers of Vitamin B-12 Status in NHANES: A Roundtable Summary. Am J Clin Nutr. 2011;94(1):313S-321S.

[4] Allen LH. How Common Is Vitamin B-12 Deficiency? Am J Clin Nutr. 2009;89(2):693S-696S.

[5] Hannibal L, Lysne V, Bjørke-Monsen AL, et al. Biomarkers and Algorithms for the Diagnosis of Vitamin B12 Deficiency. Front Mol Biosci. 2016;3:27.

[6] O'Leary F, Samman S. Vitamin B12 in Health and Disease. Nutrients. 2010;2(3):299-316.

[7] Miller JW, Garrod MG, Rockwood AL, et al. Measurement of Total Vitamin B12 and Methylmalonic Acid in Serum of Elderly Subjects. Clin Chem. 1996;42(6):858-862.

[8] Herrmann W, Obeid R. Causes and Early Diagnosis of Vitamin B12 Deficiency. Dtsch Arztebl Int. 2008;105(40):680-685.

[9] Pawlak R, Lester SE, Babatunde T. The Prevalence of Cobalamin Deficiency Among Vegetarians Assessed by Serum Vitamin B12: A Review of Literature. Eur J Clin Nutr. 2014;68(5):541-548.

[10] Baik HW, Russell RM. Vitamin B12 Deficiency in the Elderly. Annu Rev Nutr. 1999;19:357-377.

[11] Quadros EV. Advances in the Understanding of Cobalamin Assimilation and Metabolism. Br J Haematol. 2010;148(2):195-204.

[12] Carmel R. Current Concepts in Cobalamin (Vitamin B12) Deficiency. Annu Rev Med. 2000;51:357-375.

[13] Green R, Kinsella LJ. Current Concepts in the Diagnosis of Cobalamin Deficiency. Neurology. 1995;45(8):1435-1440.

[14] Antony AC. Cobalamin (Vitamin B12). In: Ross AC, Caballero B, Cousins RJ, et al., eds. Modern Nutrition in Health and Disease. 11th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:432-450.

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