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Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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Vitamin D 1.25(OH)-to-Vitamin D 25(OH) Ratio

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VIT D 1 25 OH / VIT D 25 OH

Description

"Vitamin D 1.25(OH)-to-Vitamin D 25(OH) Ratio" test compares active and stored vitamin D to evaluate how your body is processing this crucial nutrient. A skewed ratio may suggest issues like vitamin D resistance, kidney dysfunction, or parathyroid imbalance. Doctors often order this test for individuals with unexplained bone weakness or fluctuating calcium levels. Results inform treatment plans including vitamin D dosing or further diagnostics. Tracking this ratio supports balanced metabolism and stronger long-term bone health.

"Vitamin D 1.25(OH)-to-Vitamin D 25(OH) Ratio" test compares active and stored vitamin D to evaluate how your body is processing this crucial nutrient. A skewed ratio may suggest issues like vitamin D resistance, kidney dysfunction, or parathyroid imbalance. Doctors often order this test for individuals with unexplained bone weakness or fluctuating calcium levels. Results inform treatment plans including vitamin D dosing or further diagnostics. Tracking this ratio supports balanced metabolism and stronger long-term bone health.

Category

Vitamins

Procedure

Invasive

Sample Type

Blood – Serum

Units

Ratio

Procedure Category

Blood Draw

Test Group

Vitamin Group, Complete Nutrient Deficiency Group

Test Group Description

Complete Nutrient Deficiency Group: This comprehensive group includes an expanded panel of tests covering a wide range of vitamins, minerals, and other essential nutrients. Vitamin Group: This collection of tests encompasses a range of key vitamins crucial for physiological functions, aiding in nutritional status evaluation and deficiency detection.

Optimal Range

For All Individuals:

  • Conventional Unit: 1.2–1.3 R

  • SI Unit: Not Available

Normal Range

For All Individuals:

  • Conventional Unit: 1.5–1.6 R

  • SI Unit: Not Available

Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Excessive sunlight exposure

  • Excessive vitamin D supplementation

  • Over-fortification of foods with vitamin D

  • Primary hyperparathyroidism (Overactive parathyroid glands)


Decreased levels may indicate:


  • ...

Key Reasons For Testing

  • Active Vitamin D Assessment: Measures 1,25-dihydroxyvitamin D for insights into calcium absorption, bone health, and immune function.

  • Parathyroid Function: Evaluates PTH regulation to maintain calcium homeostasis and metabolic balance.

  • Kidney Function: Monitors renal conversion of vitamin D to its active form, reflecting kidney health.

  • Calcium Regulation: Assesses calcium absorption and balance, providing information on skeletal and metabolic health.

  • Endocrine Disorders: Diagnoses and manages disorders like hyperparathyroidism and renal osteodystrophy.

Health Status Conditions It May Be Used To Assess

Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Holick MF. Vitamin D Deficiency. N Engl J Med. 2007;357(3):266-281.

[2] Bouillon R, Marcocci C, Carmeliet G, et al. Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr Rev. 2019;40(4):1109-1151.

[3] Bikle DD. Vitamin D: Production and Metabolism in Health and Disease. Front Endocrinol (Lausanne). 2020;11:498.

[4] Jones G. Assay of 25-Hydroxyvitamin D: Challenge for Clinical Laboratories. Clin Chem. 2005;51(9):1683-1685.

[5] Vieth R. The Role of the 1,25(OH)₂D/25(OH)D Ratio in the Assessment of Vitamin D Status and Disorders. Nutr Rev. 2008;66(10 Suppl 2).

[6] Pettifor JM, Bikle DD, Cavaleros M, et al. Free 1,25-Dihydroxyvitamin D and Its Relationship to 25-Hydroxyvitamin D in Clinical Disorders. Ann Intern Med. 1995;122(7):511-513.

[7] Christakos S, Ajibade DV, Dhawan P, et al. Vitamin D: Molecular Mechanisms of Action and the Role of the 1,25/25 Ratio. Physiol Rev. 2016;96(1):365-408.

[8] Souberbielle JC, Prié D, Courbebaisse M, et al. The Vitamin D 1,25/25 Ratio in Diagnostic Decision-Making for Disorders of Vitamin D Metabolism. Front Endocrinol (Lausanne). 2018;9:329.

[9] Shroff R, Wan M, Nagler EV, et al. Clinical Utility of Measuring 1,25-Dihydroxyvitamin D in Chronic Kidney Disease. Nephrol Dial Transplant. 2017;32(4):681-690.

[10] Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D and Its Metabolites in the Context of Cardiovascular Risk. Circulation. 2008;117(4):503-511.

[11] Pilz S, März W, Cashman KD, et al. Rationale and Plan for Vitamin D Food Fortification: A Review. Front Endocrinol (Lausanne). 2018;9:373.

[12] Adams JS, Hewison M. Update in Vitamin D. J Clin Endocrinol Metab. 2010;95(2):471-478.

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