
High DHT

Description
This page has 46 references
"High DHT" is a hormonal condition where elevated dihydrotestosterone levels contribute to issues like male pattern baldness, acne, and prostate enlargement. DHT forms from testosterone via the enzyme 5-alpha reductase, and excess activity can negatively affect hair follicles and skin. Reducing DHT involves balancing hormones through lifestyle changes, anti-androgenic foods, or medical treatments. Understanding this hormone’s impact is essential for managing hair loss, supporting skin health, and lowering risks related to prostate function in aging men.
Symptoms & Signs
Body System
Endocrine System
Causes
Excess Testosterone Production
Things To Do
For high DHT levels, it is recommended to:
consume a whole-foods-based diet consisting of fresh vegetables, fruits, meat, fish, whole grains, legumes, and healthy fats.
Incorporate foods high in zinc, a natural DHT inhibitor. Zinc-rich foods include meat, fish, seafood, eggs, and dairy products. Zinc obtained from animal products has a much higher bioavailability than zinc obtained from plant-based sources.
Eat lycopene-rich foods that inhibit DHT activity, such as tomatoes, watermelon, pink grapefruit, apricots, etc.
include foods that can inhibit the activity or block the production of DHT. These include turmeric, onions, coconut oil, green tea, and pumpkin seeds.
Eat soy foods, such as soy beans, tofu, edamame, soy sprouts, tempeh, miso, etc. Isoflavones found in soy products can inhibit the conversion of testosterone to DHT.
Stay hydrated and drink quality mineral water and green tea.
Furthermore, do the following:
exercise regularily.
get quality sleep.
practice stress reduction. Try meditation, mindfulness, or yoga.
lose excess weight.
Things To Avoid
Avoid the following if you have elevated levels of DHT:
processed, packaged, junk, and fast foods. They contain trans fats. Trans fats have been shown to increase DHT.
Plant-based margarines also contain hydrogenated oils and tannins.
sugar, desserts, sweet pastries, candy, etc. Sugar increases DHT.
refined carbohydrates that boost DHT production.
Limit [don't exclude] saturated fat intake. Dietary cholesterol supports hormone production and the testosterone-to-DHT conversion.
caffeine, caffeinated drinks, and teas.
Furthermore, avoid:
smoking tobacco.
sedentary lifestyle.
social isolation.
spending too much time indoors.
lack of sleep.
chronic stress.
Supplements
Direct Support
(Most Helpful → Least Helpful)
These supplements directly affect high DHT by inhibiting its production, blocking its binding to receptors, or supporting hormonal balance to reduce its impact.
Zinc: Zinc helps regulate testosterone by inhibiting 5-alpha-reductase, the enzyme responsible for converting testosterone into DHT. This inhibition may reduce DHT production, supporting hormonal balance.
Indirect Support
(Most Helpful → Least Helpful)
These supplements do not target DHT directly but may support liver detoxification, reduce inflammation, or improve endocrine regulation that influences DHT levels.
No replicated and convincing research studies are available, and there is no anecdotal evidence supporting the effectiveness of this method.
Natural Compounds
These natural compounds may help manage high DHT by modulating androgen activity, supporting hormonal detox, or reducing inflammatory effects associated with elevated DHT.
Pumpkin Seed Oil: Pumpkin seed oil is rich in phytosterols that inhibit 5-alpha-reductase, reducing the conversion of testosterone into DHT. This effect supports healthier DHT levels and hormonal balance.
Flaxseed Flour: Whole flaxseed flour is a natural source of lignans—particularly secoisolariciresinol diglucoside (SDG)—which support hormonal balance by modulating androgen metabolism. These lignans help reduce the impact of DHT by increasing sex hormone-binding globulin (SHBG), making less free DHT available to bind to receptors.
Plant Extracts
Direct Support
(Most Helpful → Least Helpful)
These plant extracts directly support DHT reduction by inhibiting 5-alpha reductase activity, modulating androgen receptors, or balancing hormonal output.
Saw Palmetto Extract: Saw palmetto blocks 5-alpha-reductase, reducing the conversion of testosterone into DHT. This natural inhibition helps regulate DHT levels and supports hormonal balance.
Stinging Nettle Extract: Stinging nettle inhibits 5-alpha-reductase, decreasing the conversion of testosterone into DHT. This action helps regulate DHT levels and supports hormonal health.
Green Tea Extract: Green tea contains epigallocatechins that inhibit 5-alpha-reductase, reducing testosterone conversion into DHT. This anti-androgenic effect helps manage DHT levels naturally.
Reishi Extract: Reishi inhibits 5-alpha-reductase and modulates androgen receptor activity. Though also available as a plant extract, its studied effect in human DHT metabolism (notably in prostate health) warrants consideration in supplement form.
Curcumin Extract: Curcumin inhibits 5-alpha-reductase, reducing the conversion of testosterone into DHT. This natural pathway supports better regulation of DHT levels.
Lycopene: Lycopene down-regulates androgen metabolism, reducing the activity of 5-alpha-reductase and helping to lower DHT levels. This modulation supports hormonal balance.
Fenugreek Extract: Fenugreek inhibits both aromatase and 5-alpha-reductase, reducing testosterone breakdown and DHT production. This effect helps maintain balanced hormone levels.
Sterols: Sterols, such as beta-sitosterol, inhibit 5-alpha-reductase, decreasing testosterone conversion into DHT. This action helps lower DHT levels and supports hormonal regulation.
Indirect Support
(Most Helpful → Least Helpful)
These extracts do not act directly on DHT but may promote detoxification, reduce oxidative stress, or support metabolic processes that influence hormone regulation.
No replicated and convincing research studies are available, and there is no anecdotal evidence supporting the effectiveness of this method.
Alternative Treatments
These alternative therapies support hormonal balance, reduce androgenic stress, and promote systemic stability in individuals affected by high DHT.
Infrared Sauna: Infrared sauna helps reduce systemic inflammation and may promote hormonal detoxification, including androgens like DHT. Though indirect, there is credible support for its endocrine-balancing benefits.
Functional Lab Tests You May Wish to Explore
Books Worth Considering for Deeper Insight
Currently, no high-quality books meeting our functional, integrative, and natural healing standards are available for this condition. As soon as trusted resources are published, we will review and feature them here.
Podcasts That Offer Valuable Perspectives
Currently, no high-quality books meeting our functional, integrative, and natural healing standards are available for this condition. As soon as trusted resources are published, we will review and feature them here.
Educational Videos To Learn From
How Key Nutrients Support the Body
Fruit Extracts: Rich in antioxidants, vitamins, and fiber, fruit extracts offer numerous health benefits, including anti-inflammatory, anti-cancer, and immune-boosting properties. They also support digestive health and contribute to overall well-being.
Herbal Extracts: Herbal extracts contain bioactive compounds with various medicinal properties, including antioxidant, anti-inflammatory, and antimicrobial effects. They have been used traditionally to support digestion, immunity, and overall health.
Minerals: Minerals are essential for various physiological functions, including bone health, nerve transmission, and enzyme activity. They support overall health by ensuring proper cellular function and metabolic processes.
Essential Nutrients Explained
References
[1] Di Silverio F, Monti S, Sciarra A, et al. Effects of long-term treatment with Serenoa repens (Permixon) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia. Prostate. 1998;37(2):77-83.
[2] Marks LS, Hess DL, Dorey FJ, Luz Macairan M, Cruz Santos PB, Tyler VE. Tissue effects of saw palmetto and finasteride: use of biopsy cores for in situ quantification of prostatic androgens. Urology. 2001;57(5):999-1005.
[3] Wadsworth TL, Carroll JM, Mallinson RA, Roberts CT Jr, Roselli CE. Saw palmetto extract suppresses insulin-like growth factor-I signaling and induces stress-activated protein kinase/c-Jun N-terminal kinase phosphorylation in human prostate epithelial cells. Endocrinology. 2004;145(7):3205-3214.
[4] Opoku-Acheampong AB, Penugonda K, Lindshield BL. Effect of Saw Palmetto Supplements on Androgen-Sensitive LNCaP Human Prostate Cancer Cell Number and Syrian Hamster Flank Organ Growth. Evidence-Based Complementary and Alternative Medicine. 2016.
[5] Pais P, Villar A, Rull S. Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system. Res Rep Urol. 2016;8:41-49. Published 2016 Apr 21.
[6] [1] Ghorbanibirgani A, Khalili A, Zamani L. The efficacy of stinging nettle (urtica dioica) in patients with benign prostatic hyperplasia: a randomized double-blind study in 100 patients. Iran Red Crescent Med J. 2013;15(1):9-10.
[7] Wong KV. Stinging Nettles for Benign Prostatic Hyperplasia and Other Health Benefits. EC Nutrition. 2016, 5.5, 1228- 1231.
[8] Konrad L, Müller HH, Lenz C, Laubinger H, Aumüller G, Lichius JJ. Antiproliferative effect on human prostate cancer cells by a stinging nettle root (Urtica dioica) extract. Planta Med. 2000;66(1):44-47.
[9] Men C, Wang M, Aiyireti M, Cui Y. The Efficacy And Safety Of Urtica Dioica In Treating Benign Prostatic Hyperplasia: A Systematic Review And Meta-Analysis. Men et al., Afr J Tradit Complement Altern Med. 2016, 13(2):143-150.
[10] Johnson JJ, Bailey HH, Mukhtar H. Green tea polyphenols for prostate cancer chemoprevention: a translational perspective. Phytomedicine. 2010;17(1):3-13.
[11] Miyata Y, Shida Y, Hakariya T, Sakai H. Anti-Cancer Effects of Green Tea Polyphenols Against Prostate Cancer. Molecules. 2019;24(1):193.
[12] Khan N, Adhami VM, Mukhtar H. Review: Green Tea Polyphenols in Chemoprevention of Prostate Cancer: Preclinical and Clinical Studies. Nutrition and Cancer. 2009, 61:6, pages 836-841.
[13] H. Lee Moffitt Cancer Center & Research Institute. Component in green tea may help reduce prostate cancer in men at high risk. ScienceDaily. 2015, May.
[14] Teiten MH, Gaascht F, Eifes S, Dicato M, Diederich M. Chemopreventive potential of curcumin in prostate cancer. Genes Nutr. 2010;5(1):61-74.
[15] Piantino CB, Salvadori FA, Ayres PP, et al. An evaluation of the anti-neoplastic activity of curcumin in prostate cancer cell lines. International braz j urol. 2009, 35(3), 354-361.
[16] Killian PH, Kronski E, Michalik KM, et al. Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2 . Carcinogenesis. 2012, Vol 33, Issue 12, pp 2507–2519.
[17] Dorai T, Gehani N, Katz A. Therapeutic potential of curcumin in human prostate cancer Ð I. curcumin induces apoptosis in both androgen-dependent and androgen-independent prostate cancer cells. Department of Urology, Columbia University, College of Physicians and Surgeons, New York. Prostate Cancer and Prostatic Diseases. 2000, 3, 84±93.
[18] Rao KVK, Boukli NM, Samikkannu T, et al. Proteomics Profiling and Cytotoxic Effect of Curcuma longa on Prostate Cancer. The Open Proteomics Journal. 2011, 4, 1-11.
[19] Dhariwala MY, Ravikumar P. An overview of herbal alternatives in androgenetic alopecia. J Cosmet Dermatol. 2019;18(4):966-975.
[20] Zhu HL, Gao YH, Yang JQ, Li JB, Gao J. Serenoa repens extracts promote hair regeneration and repair of hair loss mouse models by activating TGF-ß and mitochondrial signaling pathway. Eur Rev Med Pharmacol Sci. 2018;22(12):4000-4008.
[21] Pekmezci E, Dundar C, Turkoglu M. Proprietary Herbal Extract Downregulates the Gene Expression of IL-1α in HaCaT Cells: Possible Implications Against Nonscarring Alopecia. Med Arch. 2018;72(2):136-140.
[22] Chrubasik JE, Roufogalis BD, Wagner H, Chrubasik S. A comprehensive review on the stinging nettle effect and efficacy profiles. Part II: urticae radix. Phytomedicine. 2007;14(7-8):568-579.
[23] Nakayama A, Ide H, Lu Y, et al. Effects of Curcumin Combined With the 5-alpha Reductase Inhibitor Dutasteride on LNCaP Prostate Cancer Cells. In Vivo. 2021;35(3):1443-1450.
[24] Ide H, Lu Y, Noguchi T, et al. Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer. Cancer Sci. 2018;109(4):1230-1238.
[25] Cheng Y, Yang Y, Wu Y, et al. The Curcumin Derivative, H10, Suppresses Hormone-Dependent Prostate Cancer by Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3. Front Pharmacol. 2020;11:637. Published 2020 May 8.
[26] Liu X, Allen JD, Arnold JT, Blackman MR. Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells. Carcinogenesis. 2008;29(4):816-823.
[27] Wan, Lei et al. “Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis.” Cancer prevention research (Philadelphia, Pa.) vol. 7,12 (2014): 1228-39.
[28] Applegate CC, Rowles JL 3rd, Erdman JW Jr. Can Lycopene Impact the Androgen Axis in Prostate Cancer?: A Systematic Review of Cell Culture and Animal Studies. Nutrients. 2019;11(3):633. Published 2019 Mar 15.
[29] Campbell JK, Stroud CK, Nakamura MT, Lila MA, Erdman JW Jr. Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats. J Nutr. 2006;136(11):2813-2819.
[30] Raj MV, Selvakumar K, Krishnamoorthy G, Revathy S, Elumalai P, Arunakaran J. Impact of lycopene on epididymal androgen and estrogen receptors' expression in polychlorinated biphenyls-exposed rat. Reprod Sci. 2014;21(1):89-101.
[31] Minutoli L, Bitto A, Squadrito F, et al. Serenoa Repens, lycopene and selenium: a triple therapeutic approach to manage benign prostatic hyperplasia. Curr Med Chem. 2013;20(10):1306-1312.
[32] Wilborn C, Taylor L, Poole C, Foster C, Willoughby D, Kreider R. Effects of a purported aromatase and 5α-reductase inhibitor on hormone profiles in college-age men. Int J Sport Nutr Exerc Metab. 2010;20(6):457-465.
[33] Medizin, Kosmetische & Schoen, Christiane & Bielfeldt, Stephan & Reimann, Jürgen. (2006). Fenugreek+micronutrients: Efficacy of a food supplement against hair loss. Kosmetische Medizin. 27.
[34] Umar S, Carter MJ. A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases. Case Rep Dermatol Med. 2021;2021:6659943. Published 2021 Feb 4.
[35] Stamatiadis D, Bulteau‐Portois MC, Mowszowicz I. Inhibition of 5α‐reductase activity in human skin by zinc and azelaic acid. British Journal of Dermatology. 1988 Nov;119(5):627-32.
[36] Leake A, Chisholm GD, Habib FK. The effect of zinc on the 5α-reduction of testosterone by the hyperplastic human prostate gland. Journal of steroid Biochemistry. 1984 Feb 1;20(2):651-5.
[37] Zamani P, Mokhtari O, Dehghanian F. Identification of beta-sitosterol and stigmasterol as possible inhibitors of 5 alpha-reductase 1: an in-silico study. Precision Medicine and Clinical OMICS. 2021 Dec 31;1(1).
[38] Cabeza M, Bratoef E, Heuze I, Ramírez E, Sánchez M, Flores E. Effect of beta-sitosterol as inhibitor of 5alpha-reductase in hamster prostate. InProceedings-Western Pharmacology Society 2003 Jan 1 (Vol. 46, pp. 153-155). [Western Pharmacology Society]; 1998.
[39] Ramak P, Mahboubi M. The beneficial effects of pumpkin (Cucurbita pepo L.) seed oil for health condition of men. Food Reviews International. 2019 Feb 17;35(2):166-76.
[40] Gossell-Williams M, Davis A, O'connor N. Inhibition of testosterone-induced hyperplasia of the prostate of sprague-dawley rats by pumpkin seed oil. Journal of Medicinal Food. 2006 Jun 1;9(2):284-6.
[41] Fujita R, Liu J, Shimizu K, Konishi F, Noda K, Kumamoto S, Ueda C, Tajiri H, Kaneko S, Suimi Y, Kondo R. Anti-androgenic activities of Ganoderma lucidum. Journal of ethnopharmacology. 2005 Oct 31;102(1):107-12.
[42] Liu J, Shimizu K, Konishi F, Noda K, Kumamoto S, Kurashiki K, Kondo R. Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum. Food Chemistry. 2007 Jan 1;100(4):1691-6.
[43] Zhang W, Wang X, Liu Y, Tian H, Flickinger B, Empie MW, Sun SZ. Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyperplasia. Journal of medicinal food. 2008 Jun 1;11(2):207-14.
[44] Bisson JF, Hidalgo S, Simons R, Verbruggen M. Preventive effects of lignan extract from flax hulls on experimentally induced benign prostate hyperplasia. Journal of medicinal food. 2014 Jun 1;17(6):650-6.
[45] Laukkanen JA, Laukkanen T. Sauna bathing and systemic inflammation. Eur J Epidemiol. 2018;33(3):351-353.
[46] Kunutsor SK, Laukkanen T, Laukkanen JA. Longitudinal associations of sauna bathing with inflammation and oxidative stress: the KIHD prospective cohort study. Annals of medicine. 2018 Jul 4;50(5):437-42.