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Get Healthy ~ Stay Healthy

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Jaundice

man-pointing-to-yellowish-eyes-jaundice

Description

Jaundice is a condition characterized by the yellowing of the skin and the whites of the eyes, caused by the buildup of bilirubin in the bloodstream. Bilirubin is a yellow-orange pigment that is a natural byproduct of the breakdown of red blood cells. Under normal conditions, the liver processes bilirubin and eliminates it through stool and urine. However, when the liver cannot efficiently process bilirubin—due to liver diseases such as hepatitis, bile duct blockages, or gallstones—or when red blood cells are broken down excessively, bilirubin accumulates in the blood. This accumulation leads to the visible yellow discoloration associated with jaundice. The condition can have a variety of underlying causes, including liver dysfunction, viral infections, or genetic disorders affecting red blood cell production. Identifying and addressing the root cause of jaundice is essential for effective treatment and preventing further complications, making early diagnosis crucial.

Jaundice is a condition characterized by the yellowing of the skin and the whites of the eyes, caused by the buildup of bilirubin in the bloodstream. Bilirubin is a yellow-orange pigment that is a natural byproduct of the breakdown of red blood cells. Under normal conditions, the liver processes bilirubin and eliminates it through stool and urine. However, when the liver cannot efficiently process bilirubin—due to liver diseases such as hepatitis, bile duct blockages, or gallstones—or when red blood cells are broken down excessively, bilirubin accumulates in the blood. This accumulation leads to the visible yellow discoloration associated with jaundice. The condition can have a variety of underlying causes, including liver dysfunction, viral infections, or genetic disorders affecting red blood cell production. Identifying and addressing the root cause of jaundice is essential for effective treatment and preventing further complications, making early diagnosis crucial.

Body System

[1] Katakam PK, Hegde AP, Venkataramaiahyappa M. Vitamin B12 deficiency: unusual cause of jaundice in an adolescent. BMJ Case Rep. 2018;2018:bcr2017222302. Published 2018 Jan 12.
[2] Komar VI. Uroven' kobalaminemii kak pokazatel' funktsional'nogo sostoianiia pecheni pri zheltukhakh razlichnoĭ étiologii [The blood level of cobalamin as an indicator of the functional status of the liver in jaundice of different etiologies]. Lab Delo. 1991;(9):11-12.
[3] Naha K, Dasari S, Vivek G, Hande M, Acharya V. Severe unconjugated hyperbilirubinaemia: one and one makes three?. BMJ Case Rep. 2013;2013:bcr2013009962. Published 2013 Jun 18.
[4] Erdol S, Ozgur T. Vitamin B12 deficiency associated with hyperbilirubinemia and cholestasis in infants. Pak J Med Sci. 2018;34(3):714-718.
[5] Dasari S, Naha K, Prabhu M. An unusual cause for recurrent jaundice in an otherwise healthy male. Australas Med J. 2012;5(10):541-543.
[6] Gillessen A, Schmidt HH. Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review. Adv Ther. 2020;37(4):1279-1301.
[7] Saller R, Meier R, Brignoli R. The use of silymarin in the treatment of liver diseases. Drugs. 2001;61(14):2035-2063.
[8] Šuk J, Jašprová J, Biedermann D, et al. Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice. Oxid Med Cell Longev. 2019;2019:6026902. Published 2019 Feb 12.
[9] Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010;24(10):1423-1432.
[10] Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol. 1998;93(2):139-143.
[11] El-Kamary SS, Shardell MD, Abdel-Hamid M, et al. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis. Phytomedicine. 2009;16(5):391-400.
[12] Janghel V, Patel P, Chandel SS. Plants used for the treatment of icterus (jaundice) in Central India: A review. Ann Hepatol. 2019;18(5):658-672.
[13] Hong M, Li S, Tan HY, Wang N, Tsao SW, Feng Y. Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects. Int J Mol Sci. 2015;16(12):28705-28745. Published 2015 Dec 2.
[14] Lin SC, Lin CH, Lin CC, et al. Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. J Biomed Sci. 2002;9(5):401-409.
[15] Alhusaini A, Fadda L, Hasan IH, et al. Arctium lappa Root Extract Prevents Lead-Induced Liver Injury by Attenuating Oxidative Stress and Inflammation, and Activating Akt/GSK-3ß Signaling. Antioxidants (Basel). 2019;8(12):582. Published 2019 Nov 24.
[16] Caglikulekci M, Dirlik M, Pata C, Plasse M, Tamer L, Ogetman Z, Ercan B. Effect of N-acetylcysteine on blood and tissue lipid peroxidation in lipopolysaccharide-induced obstructive jaundice. Journal of Investigative Surgery. 2006 Jan 1;19(3):175-84.
[17] Çağlıkülekci M, Pata C, Apa DD, Dirlik M, Tamer L, Yaylak F, Kanik A, Aydin S. The effect of N-acetylcysteine (NAC) on liver and renal tissue inducible nitric oxide synthase (iNOS) and tissue lipid peroxidation in obstructive jaundice stimulated by lipopolysaccharide (LPS). Pharmacological research. 2004 Mar 1;49(3):227-38.
[18] Elfarargy MS, Ali DA, Al-Ashmawy GM, Mohamed SA. Detection of serum levels of Vitamin C, D, and e in neonatal jaundice. Journal of Clinical Neonatology. 2019 Oct 1;8(4):222-6.
[19] Abdulateef Abdulrazzaq N, Habib Saifullah P, Khalied Mohammed S. Oxidative stress and antioxidant defense in patients with jaundice. Kerbala Journal of Medicine. 2014 Dec 28;7(2):2000-8.
[20] Chen J, Wu F, Long Y, Yu W. Glutathione supplementation attenuates oxidative stress and improves vascular hyporesponsiveness in experimental obstructive jaundice. Oxidative medicine and cellular longevity. 2015;2015(1):486148.
[21] Hirota M, Sugi K, Inoue M. Dynamic aspects of glutathione metabolism in obstructive jaundice. Journal of Gastroenterology. 1994 Oct;29:588-92.
[22] Turgut M, Başaran O, Cekmen MU, Karataş F, Kurt A, Aygün AD. Oxidant and antioxidant levels in preterm newborns with idiopathic hyperbilirubinaemia. Journal of paediatrics and child health. 2004 Nov;40(11):633-7.
[23] Dworkin B, Rosenthal WS, Jankowski RH, Gordon GG, Haldea D. Low blood selenium levels in alcoholics with and without advanced liver disease: Correlations with clinical and nutritional status. Digestive diseases and sciences. 1985 Sep;30:838-44.
[24] Atalay E, Ozdemir M, Tur B, Erdogdu H, Sisman P. The effect of alpha-lipoic acid on oxidative parameters and liver injury in rats with obstructive jaundice. Bratislava Medical Journal/Bratislavské Lekárske Listy. 2019 Nov 1;120(11).
[25] Somi MH, Kalageychi H, Hajipour B, Musavi G, Khodadadi A, Shokri N, Hashemi R, Bagheri I, Laleh FM. Lipoic acid prevents hepatic and intestinal damage induced by obstruction of the common bile duct in rats. European Review for Medical & Pharmacological Sciences. 2013 May 15;17(10).
[26] Kidd PM. Phosphatidylcholine, a superior protectant against liver damage. Altern Med Rev. 1996;1(4):258-74.
[27] Masood AK, Faisal SM, Mushahid MK, Nadeem A, Siddiqui MU, Owais M. Binding of bilirubin with albumin-coupled liposomes: implications in the treatment of jaundice. Biochimica et Biophysica Acta (BBA)-Biomembranes. 2002 Aug 19;1564(1):219-26.
[28] Karatepe O, Gulcicek OB, Adas G, Battal M, Kamali G, Kemik A, Altug T, Karahan S. The use of curcumin in obstructive jaundice. Archives of Medical Science. 2009 Oct 1;5(4):513-8.
[29] Tokaç M, Taner G, Aydın S, Özkardeş AB, Dündar HZ, Taşlıpınar MY, Arıkök AT, Kılıç M, Başaran AA, Basaran N. Protective effects of curcumin against oxidative stress parameters and DNA damage in the livers and kidneys of rats with biliary obstruction. Food and Chemical Toxicology. 2013 Nov 1;61:28-35.
[30] Celepli S, Çolak B, Celepli P, Bigat İ, Batur HG, Soysal F, Karakurt S, Hücümenoğlu S, Kismet K, Şahin M. Artichoke for biochemistry, histology, and gene expression in obstructive jaundice. Revista da Associação Médica Brasileira. 2022 May 13;68(5):647-52.
[31] El Sayed AM, Hussein R, Motaal AA, Fouad MA, Aziz MA, El-Sayed A. Artichoke edible parts are hepatoprotective as commercial leaf preparation. Revista Brasileira de Farmacognosia. 2018 Apr;28:165-78.
[32] Mahboubi M, Mahboubi M. Hepatoprotection by dandelion (Taraxacum officinale) and mechanisms. Asian Pacific Journal of Tropical Biomedicine. 2020 Jan 1;10(1):1-0.
[33] Elhady MM, Hassan NS. Hepatoprotective, therapeutic and in vitro cytotoxic activities of dandelion in comparison with silymarin. Egypt. J. Pure Appl. Sci.. 2014;52(2):55-63.
[34] Durkin M. Ayurvedic treatment for jaundice in Nepal. Social Science & Medicine. 1988 Jan 1;27(5):491-5.
[35] Sinha N, Ojha NK. Ayurveda management of jaundice: A case study. Journal of Research in Ayurvedic Sciences. 2023 Jul 1;7(3):166-70.

1. Vitamin B12 [Cobalamin]: Vitamin B12 is essential for proper red blood cell breakdown and bilirubin regulation. Ensuring sufficient levels helps prevent elevated bilirubin, which in turn supports healthy liver function.

2. N-Acetyl-L-Cysteine [NAC]: NAC, a precursor to glutathione, plays a critical role in liver detoxification by reducing oxidative stress and supporting liver recovery, making it beneficial for maintaining overall liver health.

3. Vitamin E: Vitamin E, a potent antioxidant, helps reduce oxidative stress in the liver. By protecting liver cells from oxidative damage, it supports the management of liver conditions associated with oxidative stress.

4. Glutathione: Glutathione, the body’s primary antioxidant, is essential for liver detoxification. It reduces oxidative stress and aids the liver in processing and eliminating toxins, helping maintain healthy liver function.

5. Selenium: Selenium enhances antioxidant defenses, particularly in the liver. By protecting liver cells from oxidative damage, it supports detoxification and overall liver health, promoting better detox capacity.

6. Alpha-Lipoic Acid [ALA]: Alpha-lipoic acid (ALA) is a powerful antioxidant that regenerates glutathione and Vitamin C. It helps protect the liver from oxidative stress and supports detoxification, enhancing liver function.

7. Phosphatidylcholine: Phosphatidylcholine supports liver health by maintaining the integrity of liver cell membranes and aiding in tissue regeneration, promoting healthy liver function during detoxification.

1. Milk Thistle Extract: Milk thistle, rich in silymarin, protects liver cells and supports detoxification processes, offering valuable support for liver health and overall detoxification.

2. Burdock Root Extract: Burdock root supports liver detoxification and may promote a healthy bilirubin profile, contributing to improved liver function and overall liver health.

3. Curcumin: Curcumin’s strong anti-inflammatory and antioxidant properties help reduce liver inflammation, support bile production, and may assist in maintaining healthy bilirubin levels, supporting liver function.

4. Artichoke Leaf Extract: Artichoke leaf promotes bile production and supports liver function, aiding in detoxification and potentially helping to maintain healthy bilirubin levels, making it beneficial for liver health.

5. Dandelion Root Extract: Dandelion root is traditionally used to support liver and gallbladder health. Its natural diuretic properties help eliminate excess fluids and toxins, supporting liver detoxification and overall liver health.

No replicated and convincing research studies are available, and there is no anecdotal evidence supporting the effectiveness of this method.

1. Ayurveda: Ayurveda incorporates specific herbs and dietary practices to improve liver function, enhance bile flow, and detoxify the body. Common herbs like Kutki (Picrorhiza kurroa), Guduchi (Tinospora cordifolia), and Bhumyamalaki (Phyllanthus niruri) are frequently used to support liver health.

Supplements

Plant Extracts

Natural Compounds

Alternative Treatments

Symptoms & Signs

Causes

Liver Cirrhosis, Preniciius Anemia, Hepatitis, Hemolysis, Biliary Tract Obstruction, Gilbert's Syndrome

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How Nutrients Function

Antioxidants: Antioxidants protect cells from oxidative stress caused by free radicals, potentially reducing the risk of chronic diseases such as cancer and cardiovascular ailments. They safeguard DNA integrity, slow down aging processes, and support overall cellular health.


Herbal Extracts: Herbal extracts contain bioactive compounds with various medicinal properties, including antioxidant, anti-inflammatory, and antimicrobial effects. They have been used traditionally to support digestion, immunity, and overall health.


Minerals: Minerals are essential for various physiological functions, including bone health, nerve transmission, and enzyme activity. They support overall health by ensuring proper cellular function and metabolic processes.


Other Nutrients: Other nutrients encompass a wide array of essential compounds crucial for various physiological functions. This category includes neurotransmitters and their precursors, which facilitate nerve signaling and are vital for central nervous system function. Additionally, naturally occurring structural components and biological detergents, such as phospholipids and bile salts, play critical roles in tissue repair, fat digestion, and overall bodily function. Phospholipids contribute to cell membrane integrity and fat emulsification, while bile salts are key to digesting and absorbing dietary fats. Hormones and their precursors regulate numerous physiological processes, including metabolism, growth, and reproduction. Furthermore, naturally occurring chemicals and metals play pivotal roles in enzymatic reactions, immune function, and overall health maintenance.


Vitamins: Vitamins are essential micronutrients that play diverse roles in supporting cellular processes, immune function, and overall health. They must be obtained through diet or supplementation to ensure proper bodily function.

Nutrients Explained In Nutritional Guide

Podcast Episodes To Listen To

Educational Videos To Learn From

Functional Lab Tests That You Might Consider

References

Things To Do

The dietary recommendations for jaundice include foods that help detoxify the liver. Incorporate the following:


  • a whole-foods-based diet composed of fresh vegetables and fruits, legumes, fish, and whole grains.

  • A high-fiber diet and antioxdiant-rich whole foods improve digestion and detoxification of the body.

  • Steam, boil, or bake your meals.

  • soups and broths.

  • whole foods rich in vitamin B12, folic acid, calcium, magnesium, and postassium. They support liver health.

  • Use coriander and turmeric to spice your meals and cleanse the liver.

  • Drink a lot of quality mineral water and coconut water.

  • Implement liver detoxifying juices, such as lemon water, beet green juice, and beet juice.

  • consume fats from whole foods, such as avocado, nuts, seeds, fish, etc.

  • Make your meals smaller but nutrient-dense. Incorporate healthy snacks.

  • Drink moderate amounts of coffee and herbal tea. They influence detoxification.


Furthermore, try the following:


  • get a lot of rest.

  • Take care of your sleep hygiene.

  • expose your body to sunlight. It helps break down bilirubin.

Things To Avoid

The foods and products you should avoid at all times when suffering from jaundice include items that can contribute to poor liver function. These include:


  • processed, junk, and fast foods high in trans fats, sugar, refined carbohydrates, added salt, food additives, and preservatives.

  • deep-fried foods, fatty foods, and grilled foods.

  • beef and pork, which require a lot of effort from the liver to support their digestion.

  • raw and undercooked seafood, including fish and shellfish.

  • packaged and smoked products, which are high in AGEs.

  • alcohol, which affects the liver.

  • white refined sugar in any form. Sugar is harmful to the liver and contributes to the development of NAFLD.

  • refined carbohydrates, such as pastas, breads, pastries, pizza dough, etc.

  • restaurant and takeout food.

  • large, heavy meals.

  • too much sodium in the diet. Sodium promotes water retention. Use other herbs and spices to flavor your meals.


Furthermore, avoid the following:


  • chronic stress.

  • strenuous physical activity.

  • smoking.

  • insufficient sleep.

  • medications.

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