Description
"S-Adenosylmethionine" (SAMe) is a biologically active molecule synthesized from methionine and ATP, integral to methylation processes. It contributes to neurotransmitter production, liver detoxification, and joint maintenance while supporting metabolic balance. Cellular repair mechanisms and antioxidant activity also depend on its biochemical role. Found throughout the body, SAMe participates in numerous physiological reactions. Its importance in metabolic pathways makes it essential for maintaining neurological health, liver function, and overall well-being.
Functions in the Body
Category
Deficiency Symptoms
There are no direct deficiency symptoms associated with SAMe.
S-Adenosylmethionine
Warnings
Caution should be exercised when taking SAMe alongside antidepressant medications, as it can amplify serotonin levels and potentially lead to serotonin syndrome. Individuals with bipolar disorder should avoid using SAMe without medical supervision, as it can exacerbate manic episodes.
Food Sources
SAMe is not obtained from food; it is synthesized in the body.
Time Frame
SAMe is most effective when taken on an empty stomach, ideally in the morning or early afternoon, to support energy levels and mood.
Depleted By
SAMe is non-essential and does not get depleted in the body, but its synthesis can be affected by low levels of methionine or B vitamins.