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Description
"Palmitoylethanolamide" (PEA) is a supplement derived from fatty acid amides, naturally produced by the body. It is associated with nerve function, cellular signaling, and musculoskeletal support. This compound plays a role in promoting physical resilience, neurological balance, and inflammatory responses. Some formulations combine PEA with quercetin or curcumin to enhance absorption and bioavailability. Frequently included in protocols addressing chronic discomfort, it provides targeted nutritional support for long-term well-being, recovery, and mobility.
Category
Fatty Acids
When To Take It
PEA can be taken any time of day, with or without food, though for consistent relief, dividing the dose between morning and evening may optimize its effects.
Synergy and Antagonism
PEA works well with quercetin, curcumin, and omega-3 fatty acids to enhance pain relief and inflammation control. However, high doses may interfere with immunomodulatory compounds like CBD and adaptogenic herbs, such as ashwagandha extract, rhodiola extract, and holy basil extract, potentially reducing their effects on immune regulation.
PEA works well with quercetin, curcumin, and omega-3 fatty acids to enhance pain relief and inflammation control. However, high doses may interfere with immunomodulatory compounds like CBD and adaptogenic herbs, such as ashwagandha extract, rhodiola extract, and holy basil extract, potentially reducing their effects on immune regulation.
Palmitoylethanolamide
May Help With The Following Conditions
At present, there is no established association between this supplement and any medical condition listed on the Health Status pages.
Warnings
Individuals on immunosuppressive therapy should consult a healthcare provider before using PEA. Pregnant or breastfeeding women should also seek guidance from a healthcare professional before use.