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Description
"S-Adenosylmethionine" (SAMe) is a supplement that provides a bioactive form of methionine, an essential compound for methylation processes. It contributes to neurotransmitter activity, influencing mood balance and emotional well-being. In joint health, SAMe plays a role in maintaining cartilage integrity, while its involvement in liver detoxification supports metabolic efficiency. Found in biochemical pathways throughout the body, this compound remains an important element in targeted supplementation for those seeking support in multiple physiological functions.
Category
Other Supplements
When To Take It
SAMe is most effective when taken in the morning on an empty stomach to support mood and energy throughout the day.
Synergy and Antagonism
SAMe works synergistically with B vitamins, particularly B6, B9 (folate), and B12, which are essential for proper methylation and homocysteine metabolism. This combination enhances its mood and joint-supporting benefits.
SAMe works synergistically with B vitamins, particularly B6, B9 (folate), and B12, which are essential for proper methylation and homocysteine metabolism. This combination enhances its mood and joint-supporting benefits.

S-Adenosylmethionine
May Help With The Following Conditions
At present, there is no established association between this supplement and any medical condition listed on the Health Status pages.
Warnings
SAMe should be used with caution by individuals on antidepressants or other psychiatric medications, as interactions may occur. Pregnant or breastfeeding women should seek medical advice before use. Some users may experience digestive issues or restlessness at higher doses.