Alpha-Synuclein Seed Amplification Assay
ALPHSYN SAA
Description
"Alpha-Synuclein Seed Amplification Assay" (α-Syn-SAA) test detects abnormal clumping of alpha-synuclein protein, a hallmark of neurodegenerative disorders like Parkinson’s disease. Doctors use this test to evaluate patients with motor symptoms or suspected early Parkinsonism. It analyzes cerebrospinal fluid to identify protein aggregates that may not appear on standard imaging. A positive result suggests elevated risk for conditions like Parkinson’s or multiple system atrophy. This test supports early detection, refines diagnosis, and helps guide next steps in neurologic care.
Test Category
Proteins
Procedure
Invasive
Sample Type
Blood – Serum | Fluid
Units
Not Applicable
Procedure Category
Insert, Extract
Test Group
Chronic Illness Group
Test Group Description
Chronic Illness Group: This group encompasses a range of tests specifically tailored to assess markers associated with chronic health conditions, providing comprehensive insights into the management and monitoring of chronic illnesses.
Optimal Range
For All Individuals:
Result: Negative: No abnormalities detected.
Normal Range
For All Individuals:
Result: Negative: No abnormalities detected.
Results That Differ From The Norm (Direct and Indirect Causes)
Abnormal results may indicate:
Dementia with Lewy bodies (Cognitive decline, visual hallucinations, and motor symptoms)
Multiple system atrophy (Neurodegenerative disorder affecting movement and autonomic function)
Parkinson's disease (Neurodegenerative disorder characterized by motor symptoms)
Key Reasons For Testing
Parkinson’s Disease Diagnosis: Detects abnormal alpha-synuclein protein, a hallmark of the disease.
Differential Diagnosis: Distinguishes Parkinson’s from conditions like MSA or dementia with Lewy bodies.
Early Disease Detection: Identifies early signs for prompt treatment and management.
Monitoring Disease Progression: Tracks the spread of protein clumps to assess disease stages.
Health Status Conditions It May Be Used To Assess
Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.
Some Prominent Medical Labs That May Offer This Test
Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.
References
Important Note
Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.
Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.
Disclaimer
This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.
Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.
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[2] Sano K, Kondru NC, Yoshioka H, et al. Early detection of α-synuclein seeds in the CSF of patients with dementia with Lewy bodies and Parkinson's disease. Mov Disord. 2021;36(3):774-783.
[3] Shahnawaz M, Tokuda T, Waragai M, et al. Development of a bioluminescent assay for alpha-synuclein in cerebrospinal fluid. Acta Neuropathol Commun. 2017;5(1):86.
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[8] Groveman BR, Orrú CD, Hughson AG, et al. Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by RT-QuIC. Acta Neuropathol Commun. 2018;6(1):7.
[9] Russo MJ, Orrú CD, Concha-Marambio L, et al. High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of MSA, Parkinson’s disease, and dementia with Lewy bodies. Acta Neuropathol.2021;142(1):77-81.