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Essential4Health

Get Healthy ~ Stay Healthy

Essential4Health

Get Healthy ~ Stay Healthy

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APO B / APO A1

Description

"Apolipoprotein B-to-Apolipoprotein A1 Ratio" test compares ApoB and ApoA1 levels to assess the balance between harmful and protective cholesterol particles. A high ratio can indicate elevated risk for heart disease, especially when traditional cholesterol numbers appear normal. This test is especially valuable for people with metabolic syndrome or strong family history of cardiovascular conditions. Results help guide prevention strategies—such as dietary shifts, exercise plans, or medications—and track how well your heart health plan is working over time.

"Apolipoprotein B-to-Apolipoprotein A1 Ratio" test compares ApoB and ApoA1 levels to assess the balance between harmful and protective cholesterol particles. A high ratio can indicate elevated risk for heart disease, especially when traditional cholesterol numbers appear normal. This test is especially valuable for people with metabolic syndrome or strong family history of cardiovascular conditions. Results help guide prevention strategies—such as dietary shifts, exercise plans, or medications—and track how well your heart health plan is working over time.

Category

Proteins, Lipids

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Apolipoprotein B-to-Apolipoprotein A1 Ratio

Procedure

Invasive

Sample Type

Blood – Serum

Units

Ratio

Procedure Category

Blood Draw

Test Group

Basic Cardiovascular Group, Complete Cardiovascular Group, Cardio Risk Group, Lipoprotein Group

Test Group Description

Basic Cardiovascular Group: This group includes fundamental tests targeting essential markers related to cardiovascular health, providing foundational insights into cholesterol levels, blood pressure, and other key factors. Cardio Risk Group: This group focuses on assessing various markers associated with cardiovascular health and risk factors, aiding in the early detection and management of cardiovascular diseases. Complete Cardiovascular Group: This group contains comprehensive tests for an extensive evaluation of cardiovascular health, providing thorough insights into heart-related conditions beyond basic assessments. Lipoprotein Group: This small group evaluates lipoprotein levels and related parameters, offering insights into lipid metabolism and cardiovascular health.

Normal Range

Optimal Range

For Men:

  • Conventional Unit: 0.0–0.7 R

  • SI Unit: Not Applicable


For Women:

  • Conventional Unit: 0.0–0.6 R

  • SI Unit: Not Applicable

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For All Individuals:

  • Conventional Unit: 0.0–0.8 R

  • SI Unit: Not Applicable

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Key Reasons For Testing

  • Cardiovascular Risk Assessment: Higher ratios indicate a greater risk of heart disease.

  • Lipid Profile Evaluation: Assesses the balance between "bad" cholesterol (apoB) and "good" cholesterol (apoA1).

  • Atherosclerosis Prediction: Identifies ratios linked to an increased risk of clogged arteries.

  • Treatment Response Monitoring: Tracks changes in the ratio to evaluate the effectiveness of heart disease treatments.

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Results That Differ From The Norm (Direct and Indirect Causes)

Increased levels may indicate:


  • Atherosclerosis (Buildup of fatty deposits in the arteries)

  • Dyslipidemia (Abnormal levels of lipids in the blood)

  • Metabolic syndrome (cluster of conditions including high blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol levels)

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Currently, this test is not directly associated with any conditions listed on the Health Status page. However, it may be included as part of a broader set of tests linked to specific health conditions.

Health Status Conditions It May Be Used To Assess

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Some Prominent Medical Labs That May Offer This Test

Please note that this particular test has not been associated with any of the listed prominent medical labs. We recommend enquiring with your private physician or nearest hospital to determine where this specific test can be performed.

References

Important Note

Any medical procedure yielding results outside the norm may be directly or indirectly linked to the conditions outlined on this page. Various factors, including genetics, medication and supplement usage, recent illnesses, pregnancy, pre-test eating, smoking, and stress, can impact the test's outcome. Additionally, factors like false positives, false negatives, inaccurate analyses, and others can influence results.


Reference ranges, which help healthcare professionals interpret medical tests, may vary depending on age, gender, and other factors. They may also differ between laboratories due to variations in instruments and methods used. Optimal ranges are designed for preventive purposes, aiming to identify trends and potential risks early, while normal ranges reflect conventional laboratory values indicating no current disease or pathology. Your healthcare practitioner may have specific reasons for testing that deviate from the usual or may interpret results differently based on individual circumstances. Proper interpretation typically involves considering clinical findings and other diagnostic tests. Hence, it is crucial to provide your healthcare professionals with a comprehensive medical history, consult with them for result interpretation, and follow their guidance for potential re-testing or additional diagnostics.

Disclaimer

This content is provided solely for informative and educational purposes. It is not intended as a substitute for medical advice or treatment from a personal physician. Regarding the interpretation of their medical test results and/or specific health questions, it is recommended that all readers and viewers consult their physicians or other qualified health professionals. The publisher is not responsible for any adverse health effects that may result from reading or following the information in this educational content. Before beginning any nutrition, supplement, or lifestyle program, all viewers, especially those taking prescription or over-the-counter medications, should consult their physician or health care practitioner.


Please note that while prominent lab names are included in this content, we cannot guarantee that these labs offer all the tests mentioned. For confirmation, individuals should contact the labs directly or consult their medical practitioners. The information provided reflects general knowledge at the time of publication and may not include recent updates or emerging research. Readers should verify details with qualified professionals to ensure the most up-to-date and accurate guidance.

[1] Walldius G, Jungner I. The apoB/apoA-I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy: a review of the evidence. J Intern Med. 2006;259(5):493-519.
[2] McQueen MJ, Hawken S, Wang X, et al. Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study. Lancet. 2008;372(9634):224-233.
[3] Yusuf S, Hawken S, Ounpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364(9438):937-952.
[4] Ridker PM, Rifai N, Cook NR, Bradwin G, Buring JE. Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA. 2005;294(3):326-333.
[5] Farhan S, Jarai R, Tentzeris I, et al. The predictive value of apolipoprotein B/A-I ratio in patients with premature myocardial infarction. Am Heart J. 2011;162(4):702-705.
[6] Kappelle PJ, Gansevoort RT, Hillege HL, et al. Apolipoprotein B/A-I and total cholesterol/high-density lipoprotein cholesterol ratios both predict cardiovascular events in the general population independently of nonlipid risk factors. Hypertension. 2011;58(6):928-936.
[7] Lima LM, Sampaio MF, Ribeiro A, et al. Apo B/apo A-I ratio and cardiovascular risk prediction. Arq Bras Cardiol.2007;88(6):681-687.
[8] Tian M, Wang J, Peng Y, et al. Comparison of Apolipoprotein B/A1 ratio, Framingham risk score, and TC/HDL-c for predicting clinical outcomes in patients undergoing percutaneous coronary intervention. Lipids Health Dis.2019;18(1):202.
[9] Jing F, Mao Y, Guo J, et al. The value of Apolipoprotein B/Apolipoprotein A1 ratio for metabolic syndrome diagnosis in a Chinese population: a cross-sectional study. Lipids Health Dis. 2014;13:81.
[10] Panayiotou A, Griffin M, Georgiou N, et al. ApoB/ApoA1 ratio and subclinical atherosclerosis. Int Angiol.2008;27(1):74-80.
[11] Öhman M, Dahlqvist SR, Rantapää-Dahlqvist S. The apoB/apoA1 ratio predicts future cardiovascular events in patients with rheumatoid arthritis. Scand J Rheumatol. 2014;43(4):259-264.

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