Description
"Citrulline" is a non-essential amino acid naturally present in watermelon, squash, and cucumbers, as well as synthesized by the body. In the kidneys, it converts into arginine, a nitric oxide precursor that regulates vascular tone and circulation. Citrulline also interacts with metabolic pathways that support muscle recovery and endurance. Additionally, it aids in ammonia clearance, helping reduce exercise-induced fatigue. As a key factor in cardiovascular and muscular function, citrulline plays a vital role in metabolic balance.
Functions in the Body
Category
Deficiency Symptoms
Since citrulline is not an essential nutrient, there are no deficiency symptoms associated with its absence.
Synergists & Antagonists
Citrulline works synergistically with arginine and nitric oxide boosters to improve blood flow and exercise performance. There are no significant antagonistic interactions reported.
Citrulline
Warnings
Caution is advised during pregnancy and breastfeeding, as the safety of citrulline supplementation has not been well established for these groups.
Food Sources
Natural food sources of citrulline include cucumbers, pumpkins, watermelon, cantaloupe, and squash.
Time Frame
Citrulline is best taken before a workout, as it may help improve exercise performance by supporting blood flow and reducing muscle fatigue.
Depleted By
There are no specific dietary or lifestyle factors that deplete citrulline.