Description
"Gamma-Linolenic Acid" (GLA) is an omega-6 fatty acid derived from plant-based sources such as evening primrose, borage, and black currant seed oils. It participates in enzymatic pathways that regulate inflammatory balance, hormonal activity, and vascular elasticity. GLA also contributes to metabolic interactions that influence immune modulation and cellular resilience. Additionally, it engages with biochemical processes tied to lipid metabolism and skin barrier integrity. Recognized for its physiological applications, this fatty acid remains integral to systemic equilibrium and nutritional wellness.
Functions in the Body
Category
Deficiency Symptoms
A deficiency in GLA may lead to pain, nausea, cramps, vomiting, headaches, bloating, dry hair, cracked skin, and brittle nails.
Synergists & Antagonists
GLA works synergistically with omega-3 fatty acids, like EPA and DHA, to promote anti-inflammatory effects and support overall health. There are no significant antagonistic interactions reported, though caution should be taken with medications affecting blood clotting.
Gamma-Linolenic Acid
Warnings
GLA should be avoided by individuals with seizure disorders or bleeding disorders. It may interact with anticoagulants, antiplatelet medications, and phenothiazines. Use caution when combining with blood-thinning medications.
Food Sources
Rich food sources of GLA include borage oil, evening primrose oil, blackcurrant oil, fungal oil, and hemp seed oil.
Time Frame
Best consumed with a meal containing fat, as GLA is fat-soluble and requires dietary fats for optimal absorption.
Depleted By
Factors such as alcohol, laxatives, immunosuppressants, hormone replacements, statins, and anti-cancer medications may deplete GLA levels or impair its effectiveness.