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Description
"Melatonin" is a supplement containing a naturally occurring hormone that regulates the sleep-wake cycle. It helps synchronize circadian rhythms by responding to light and darkness, promoting a structured sleep pattern. Its antioxidant properties strengthen cellular defense, while its influence on immune signaling supports overall physiological balance. Various sleep-support products feature melatonin as a key ingredient, often combined with calming botanicals. Its connection to biological rhythms makes it a valued addition to nighttime wellness solutions and relaxation blends.
Category
Hormones
When To Take It
Melatonin should be taken shortly before bed to encourage a natural sleep cycle and promote relaxation.
Synergy and Antagonism
Melatonin works in synergy with magnesium, tryptophan, 5-HTP, vitamin B12, and GABA to support restful sleep and regulate circadian rhythm. However, excessive caffeine intake may counteract its effects, disrupting natural sleep cycles.
Melatonin works in synergy with magnesium, tryptophan, 5-HTP, vitamin B12, and GABA to support restful sleep and regulate circadian rhythm. However, excessive caffeine intake may counteract its effects, disrupting natural sleep cycles.

Melatonin
May Help With The Following Conditions
At present, there is no established association between this supplement and any medical condition listed on the Health Status pages.
Warnings
Melatonin supplementation should be approached with caution during pregnancy, when planning to conceive, or while breastfeeding. It may interact with medications such as aspirin, birth control pills, caffeine, diabetes treatments, immunosuppressants, and sedatives. Overuse of melatonin can disturb the body's natural circadian rhythm, potentially worsening sleep quality if taken in high doses or incorrectly.