Description
"Glutamate" is a non-essential amino acid synthesized from glutamine, primarily found in the brain and central nervous system. This neurotransmitter actively modulates excitatory signaling, crucial for memory formation, cognitive performance, and synaptic adaptability. It also serves as a precursor to GABA, balancing neuronal stimulation and preventing overstimulation. Through its metabolic roles, glutamate sustains energy production in muscles and gastrointestinal cells. By sustaining neural communication and metabolic pathways, glutamate remains fundamental to brain function and energy regulation.
Functions in the Body
Category
Deficiency Symptoms
A deficiency in glutamate may result in disrupted nerve health and communication, leading to insomnia, concentration problems, mental fatigue, apathy, paranoia, agitation, and in severe cases, auditory hallucinations.
Synergists & Antagonists
Glutamate works antagonistically with GABA, the main inhibitory neurotransmitter in the brain, as the two maintain a delicate balance in the central nervous system. While glutamate promotes excitatory signaling, GABA tempers it. No well-documented synergistic interactions exist.
Glutamate
Warnings
Glutamate interacts with anti-seizure medications and may affect individuals with monosodium glutamate (MSG) sensitivity, epilepsy, or bipolar disorder. Increased levels of glutamate may exacerbate symptoms in these conditions.
Food Sources
Rich food sources of glutamate include meat, poultry, eggs, tomatoes, cheese, mushrooms, and soy-based products.
Time Frame
Glutamate can be consumed anytime and is naturally present in various protein-rich foods.
Depleted By
Glutamate levels may be reduced by lamotrigine (an anti-epileptic medication), alcohol consumption, and excessive intake of GABA supplements.