Description
"Berberine" is a naturally occurring isoquinoline alkaloid found in plants such as Oregon grape, goldenseal, and barberry. It modulates cellular enzymes and biochemical pathways involved in metabolic regulation, redox balance, and microbial interactions. This compound also engages with molecular targets linked to lipid metabolism, glucose homeostasis, and cellular signaling. Furthermore, berberine influences enzymatic reactions associated with gut microbiota composition and bile acid metabolism. As a plant-derived alkaloid, berberine remains an integral component of botanical formulations and metabolic research.
Functions in the Body
Category
Deficiency Symptoms
As berberine is not an essential nutrient, there are no deficiency symptoms associated with its absence.
Synergists & Antagonists
Berberine is commonly used with alpha-lipoic acid, CoQ10, milk thistle, and pancreatic enzymes for blood sugar and liver support. However, it may interact with supplements that lower blood sugar or blood pressure, including arginine, fish oil, and sedative herbs.
Berberine
Warnings
Berberine should not be combined with diabetes medication, Cyclosporine, blood clotting medication, or high blood pressure medication without medical supervision, as it may amplify their effects.
Food Sources
Berberine is found in natural sources such as European barberry, goldenseal, Oregon grape, bayberry, coptis, and tree turmeric.
Time Frame
Berberine is best taken before meals to optimize its effects on blood sugar and digestion.
Depleted By
Berberine is not depleted by any specific dietary or lifestyle factors.