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Essential4Health

Evidence-based natural health

Essential4Health

Evidence-based natural health

portrait-senior-man-holding-glasses-macular-degeneration-concept
"Macular Degeneration" is a progressive eye disorder that damages the macula, the part of the retina responsible for sharp central vision. This condition is one of the leading causes of vision loss in older adults. Early symptoms include blurred vision or trouble seeing in low light. The condition occurs in two types: dry (gradual) and wet (rapid). Nutrients like lutein, zinc, and vitamin A may help slow progression. Regular eye exams are vital for early detection and vision preservation.

Description

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"Macular Degeneration" is a progressive eye disorder that damages the macula, the part of the retina responsible for sharp central vision. This condition is one of the leading causes of vision loss in older adults. Early symptoms include blurred vision or trouble seeing in low light. The condition occurs in two types: dry (gradual) and wet (rapid). Nutrients like lutein, zinc, and vitamin A may help slow progression. Regular eye exams are vital for early detection and vision preservation.

Symptoms & Signs

Blurred Vision, Color Vision Problems, Low Vision, Poor Night Vision, Straight Lines Look Curvy, Visual Dark-Spots

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Macular Degeneration

Body System

Eyes and Vision

Causes

Atherosclerosis, Oxidative Stress, Aging, Hypertension, Environmental Toxins, Obesity, Smoking

Things To Do

The dietary recommendations for macular degeneration include:


  • consuming a whole-foods-based diet consisting of fresh vegetables and fruits, meat, fish, legumes, whole grains [in moderation], and healthy fats.

  • a low-carbohydrate diet that may slow down the progression of the condition.

  • high-fiber diet promotes gut health and has a positive impact on eye health.

  • incorporate a large amount of fresh vegetables and low-glycemic fruits [such as berries]. They are rich sources of antioxidant compounds, vitamins, and minerals. Antioxidants help combat the free radicals that cause damage to the maticula.

  • Three carotenes, lutein, lycopene, and zeaxanthin, are especially beneficial for eye health. They are the yellow and orange pigments found in fruits and vegetables.

  • include sulforaphane-rich foods, such as broccoli, brussel sprouts, dark leafy greens, cabbage, watercress, etc. Sulforaphane has been found to promote retinal regeneration.

  • include zinc-containing foods, such as fish, seafood, shellfish, meat, eggs, etc. Zinc supports eye health.

  • Drink moderate amounts of red wine if your health allows you to. Red wine contains anthocyanins, which are potent antioxidants.

  • Coffee consumption can promote eye health. Chlorogenic acid is a potent antioxidant that protects the eyes.

  • Stay hydrated. Drink quality mineral water and herbal teas.


Other helpful habits include:


  • getting enough quality sleep. Sleep deprivation increases the risk of developing macular degeneration.

  • regular physical exercise. Low-to-moderate-intensity physical activity benefits eye health.

  • Intermittent fasting induces autophagy. Autophagy slows down the progression of macular degeneration and has protective effects on eye health.

  • Wear sunglasses and blue light-blocking glasses when staying outdoors and using screens. Blue light is strenuous for the eyes and may induce oxidative damage to the retina.

  • maintain a healthy weight, blood sugar, and blood pressure levels.

Things To Avoid

Avoid the following products and foods:


  • processed, junk, and fast foods. They contain trans fatty acids, sugar, refined carbohydrates, food additives, and food preservatives.

  • Trans fats and hydrogenated vegetable and seed oils increase the risk of developing macular degeneration.

  • sugar, which contributes to the formation of AGEs [advanced glycation end products]. AGEs are highly inflammatory and speed up the progression of degenerative diseases.

  • deep-fried and grilled foods. They are high in AGEs.

  • food additives, such as monosodium glutamate [MSG]. MSG is a flavor enhancer that has harmful effects on eye health.

  • Refined carbohydrates increase blood glucose levels and therefore impact the development and progression of macular degeneration.

  • Beer consumption contributes to drusen accumulation. Large drusen are associated with age-related macular degeneration.


Furthermore, avoid the following:


  • sleep deprivation and insomnia.

  • lack of physical activity.

  • being overweight and obese.

  • metabolic issues, such as hypertension and diabetes.

  • smoking, which contributes to systemic inflammation.

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ℹ️ Guidance Note
Not a protocol—each modality is listed individually with references; anecdotes are flagged
 

Usage rules
 

  • Use one modality per session within the listed frequency and duration

  • Add new modalities one at a time, week by week

  • Stop immediately if adverse symptoms occur
     

Combining rules
 

  • Combine modalities only if explicitly allowed in the entry

  • Avoid overlapping heat or intensive manual therapies on the same day unless specified

  • Use only listed synergies; otherwise do not combine in the same session


Professional Care
 

  • Follow the fixed safe-use lines where indicated (e.g., acupuncture requires a licensed practitioner)

  • See Global Safety Note below

ℹ️ Guidance Note
Not a protocol—each plant active is listed individually with references; anecdotes are flagged
 

Introduce gradually
 

  • Start with one plant active

  • Add one new plant active every 7 days if tolerated

  • Keep ≤2 changes at once
     

Stacking rules
 

  • Avoid combining herbs with the same primary Effect

  • Always check for drug–herb interactions and photosensitivity

  • Use only listed synergies; avoid antagonisms or separate by the stated time


Use Window
 

  • Respect each item’s Timing and Duration caps

  • Patch-test topicals and dilute essential oils to the listed %

  • See Global Safety Note below

Clinician-managed


These options do not replace prescribed care. “Therapeutic Dose” denotes the upper limit (“Up to …”), and “Duration” denotes the Safe Duration cap — at the Recommended Dose you may continue or cycle beyond this window if symptoms persist and no adverse effects occur; at the Therapeutic Dose do not extend without clinician oversight. A clinician may extend or cycle beyond this window with clinical justification. Coordinate changes, lab-guided dosing, cycling, and peri-procedure holds with your clinician, and review drug–nutrient interactions. Use quality-tested products; patch test topicals; dilute essential oils; avoid eyes/mucosa.

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Supplements

Direct Support

(Most Helpful → Least Helpful)

These supplements directly affect macular degeneration by protecting retinal cells, reducing oxidative damage, or supporting macular pigment density.

1. Zinc 🔗 (view details)

  • Function: Zinc helps reduce the risk of age-related macular degeneration by supporting retinal cell health. It also stimulates autophagy, a cellular recycling process that improves nutrient flow and waste clearance, enhancing overall retinal function.

  • Recommended Dose: 15–25 mg/day elemental

  • Therapeutic Dose: Up to 40 mg/day elemental

  • Form: Capsule

  • Timing: With meals

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: Long-term high doses may lower copper; consider copper if extended; separate from iron/calcium by ≥2 h.


2. Taurine 🔗 (view details)

  • Function: Taurine supports retinal health by enhancing antioxidants like glutathione and reducing oxidative stress markers. It also boosts enzymes like superoxide dismutase and catalase, protecting the retina from degeneration.

  • Recommended Dose: 1,000–2,000 mg/day

  • Therapeutic Dose: Up to 3,000 mg/day

  • Form: Capsule or powder

  • Timing: With meals

  • Duration: Ongoing

  • Cautions & Safety Notes: May lower blood pressure; caution with antihypertensives.


3. Astaxanthin Extract 🔗 (view details)

  • Function: Astaxanthin is a potent antioxidant that helps reduce oxidative stress and inflammation in the retina, protecting the integrity of retinal cells. Its effects contribute to long-term visual health and overall eye protection.

  • Recommended Dose: 4–6 mg/day

  • Therapeutic Dose: Up to 12 mg/day

  • Form: Softgel or capsule

  • Timing: With meals

  • Duration: 4–12 weeks

  • Cautions & Safety Notes: May cause mild skin pigmentation at higher doses.


4. Omega 3 🔗 (view details)

  • Function: Omega-3 supports retinal cell health and may improve visual acuity by protecting the retina from damage. It helps maintain healthy retinal cell membranes, which is crucial for preventing the progression of macular degeneration.

  • Recommended Dose: 1,000–2,000 mg/day (EPA + DHA)

  • Therapeutic Dose: Up to 3,000 mg/day (EPA + DHA)

  • Form: Softgel or oil

  • Timing: With meals

  • Duration: Ongoing

  • Cautions & Safety Notes: May thin blood at higher doses; choose purified products.


5. Vitamin E 🔗 (view details)

  • Function: Vitamin E acts as an antioxidant that protects the retina and macula from oxidative stress. By reducing cellular damage in these areas, it contributes to preserving vision and slowing degenerative eye conditions over time.

  • Recommended Dose: 100–200 IU/day

  • Therapeutic Dose: Up to 400 IU/day

  • Form: Softgel or liquid drops

  • Timing: With meals

  • Duration: 4–6 weeks

  • Cautions & Safety Notes: May thin blood; caution with anticoagulants.


6. Vitamin C 🔗 (view details)

  • Function: Vitamin C, as a powerful antioxidant, combats oxidative stress in the retina and macula, helping protect these critical areas from damage. Its role in neutralizing free radicals supports long-term eye health and can slow the progression of degenerative changes.

  • Recommended Dose: 1,000–2,000 mg/day (ascorbic acid; divided doses) or 80–160 mg/day (fruit-extract capsules; divided doses)

  • Therapeutic Dose: Up to 3,000 mg/day (ascorbic acid; divided doses) or up to 240 mg/day (fruit-extract capsules; divided doses)

  • Form: Capsule or powder

  • Timing: With meals

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: GI upset/loose stools are more common with ascorbic acid; fruit-extract vitamin C is usually gentler. Kidney-stone history—use caution and hydrate. Vitamin C increases iron absorption—if you have high iron levels or were told to limit iron, check with your clinician. Separate from aluminum-containing antacids by 2 hours.


7. Selenium 🔗 (view details)

  • Function: Selenium helps protect the retina from oxidative damage, supporting overall eye health. Its antioxidant properties play a crucial role in preserving the structural integrity of retinal cells.

  • Recommended Dose: 100–200 mcg/day elemental

  • Therapeutic Dose: Up to 400 mcg/day elemental

  • Form: Capsule or tablet

  • Timing: With meals

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: Do not exceed 400 mcg/day; selenosis risk (hair/nail changes, GI upset).


8. Copper 🔗 (view details) 

  • Function: Copper supports retinal health by preventing deficiencies when taking high doses of zinc. It also helps maintain healthy blood vessels and protects the retina from oxidative stress, contributing to the long-term preservation of vision.

  • Recommended Dose: 2 mg/day elemental

  • Therapeutic Dose: Up to 4 mg/day elemental

  • Form: Capsule or tablet

  • Timing: With meals

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Balance with zinc; avoid excess.


9. Vitamin B-Complex 🔗 (view details)

  • Function: B vitamins reduce homocysteine levels, which are associated with increased risk of AMD progression. Vitamin B-complex supplementation slows the development of AMD, particularly in high-risk individuals.

  • Recommended Dose: B1 (Thiamine) 10–25 mg/day; B2 (Riboflavin) 10–25 mg/day; B3 (Niacinamide) 16–50 mg/day; B5 (Pantothenic acid) 50–100 mg/day; B6 2–10 mg/day; B7 (Biotin) 30–100 mcg/day; Folate (5-MTHF) 400–800 mcg/day; B12 250–500 mcg/day

  • Therapeutic Dose: B1 up to 100 mg/day; B2 up to 100 mg/day; B3 (Niacinamide) up to 500 mg/day; B5 up to 500 mg/day; B6 up to 25 mg/day; B7 (Biotin) up to 300 mcg/day; Folate (5-MTHF) up to 1,000 mcg/day; B12 up to 1,000 mcg/day

  • Form: Capsule or tablet

  • Timing: With meals

  • Duration: Ongoing

  • Cautions & Safety Notes: High-dose B6 neuropathy >100 mg/day; nicotinic acid may cause flushing—prefer niacinamide in complexes; high-dose niacinamide may affect glycemic control/liver; biotin can interfere with lab tests (thyroid, troponin); folate can mask B12 deficiency—ensure B12 replete before >400 mcg/day; bright yellow urine from riboflavin is normal.

Indirect Support

(Most Helpful → Least Helpful)

These supplements do not target macular degeneration directly but may support vascular health, improve antioxidant capacity, or enhance nutrient delivery to the eyes.

1. Vitamin D 🔗 (view details)

  • Function: Vitamin D helps protect retinal cells from damage by reducing inflammation and supporting immune function. It plays a critical role in maintaining healthy eye tissues and may help prevent the progression of macular degeneration.

  • Recommended Dose: 2,000–4,000 IU/day D3 + K2 MK-7 90–200 mcg/day

  • Therapeutic Dose: Up to 10,000 IU/day D3

  • Form: Softgel or liquid drops

  • Timing: With meals

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: Monitor 25(OH)D and calcium at higher intakes; avoid unsupervised high doses in granulomatous disease or primary hyperparathyroidism; caution with thiazides/digoxin; vitamin K2 may antagonize warfarin.


2. Alpha Lipoic Acid 🔗 (view details)

  • Function: Alpha-lipoic acid boosts antioxidant defenses by regenerating glutathione and other antioxidants. This reduction of oxidative stress in retinal cells helps protect against damage and supports long-term retinal health in individuals with AMD.

  • Recommended Dose: 300–600 mg/day

  • Therapeutic Dose: Up to 1,200 mg/day

  • Form: Capsule or tablet

  • Timing: Empty stomach

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: May lower blood glucose—monitor if using antidiabetic drugs; caution in thyroid disorders; ensure thiamine sufficiency (alcohol misuse, malnutrition); avoid during chemotherapy/radiation unless clinician-approved; GI upset or insomnia possible.


3. N-Acetyl-L-Cysteine [NAC] 🔗 (view details)

  • Function: N-acetyl-L-cysteine (NAC) boosts glutathione levels in the retina, helping protect against oxidative stress. Its ability to support antioxidant activity helps prevent retinal cell damage, offering potential benefits for macular health.

  • Recommended Dose: 600 mg/day

  • Therapeutic Dose: Up to 1,800 mg/day

  • Form: Capsule or powder

  • Timing: Empty stomach

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: GI upset possible; avoid with nitrates (e.g., nitroglycerin, isosorbide); caution in asthma (inhaled forms).


4. Coenzyme Q10 [CoQ10] 🔗 (view details)

  • Function: Coenzyme Q10 supports retinal cell function by enhancing mitochondrial energy production and reducing oxidative damage. Its antioxidant properties help preserve visual function and slow the degenerative changes in AMD.

  • Recommended Dose: 100–200 mg/day

  • Therapeutic Dose: Up to 300 mg/day

  • Form: Softgel

  • Timing: With meals

  • Duration: Ongoing

  • Cautions & Safety Notes: May reduce warfarin effect (↓INR).

Natural Compounds

These natural compounds may help manage macular degeneration by supporting retinal nourishment, reducing light-induced damage, or promoting antioxidant protection.

No replicated and convincing research studies are available, and there is no anecdotal evidence supporting the effectiveness of this method.

Plant Actives

Direct Support

(Most Helpful → Least Helpful)

These plant extracts directly support macular health by providing retinal antioxidants, reducing inflammation in ocular tissues, or protecting photoreceptor cells.

1. Lutein 🔗 (view details)

  • Function: Lutein increases macular pigment density, which enhances visual clarity and protects the retina from oxidative stress. This pigment enhancement supports long-term eye health and helps maintain sharp vision.

  • Recommended Dose: 10–20 mg

  • Therapeutic Dose: Up to 40 mg

  • Form & Preparation: Capsule

  • Timing: With meals

  • Duration: Ongoing

  • Cautions & Safety Notes: Orlistat and bile-acid sequestrants may reduce absorption—separate by 2 hours; rare carotenoderma (yellowing of skin) with high intakes; discontinue if hypersensitivity.


2. Zeaxanthin 🔗 (view details)

  • Function: Zeaxanthin helps protect the macula and retina from oxidative stress, which is essential for supporting healthy vision. It plays a crucial role in preserving long-term eye function and clarity.

  • Recommended Dose: 2–4 mg

  • Therapeutic Dose: Up to 10 mg

  • Form & Preparation: Capsule

  • Timing: With meals

  • Duration: Ongoing

  • Cautions & Safety Notes: Generally well tolerated; fat-soluble—take with food; rare GI upset or headache; discontinue if hypersensitivity.


3. Saffron Extract

  • Function: Saffron improves visual function and slows retinal degeneration in early AMD. Its antioxidant and neuroprotective properties directly benefit macular health.

  • Recommended Dose: 28–60 mg (3.5% bioactives)

  • Therapeutic Dose: Up to 90 mg (3.5% bioactives)

  • Form & Preparation: Capsule

  • Timing: With meals

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: May increase bleeding risk—use caution with blood thinners; may lower blood pressure—use caution with antihypertensives; possible interaction with antidepressants—monitor for agitation, restlessness, or GI upset; stop 7 days before surgery; discontinue if hypersensitivity.


4. Bilberry Extract 🔗 (view details)

  • Function: Bilberry boosts antioxidant defenses, inhibits lipid peroxidation, and helps prevent retinal cell death. These protective effects support better retinal function and contribute to maintaining optimal eye health.

  • Recommended Dose: 160–320 mg (25–36% anthocyanins) (capsule) or 1–2 mL (tincture; ≈ 20–40 drops)

  • Therapeutic Dose: Up to 480 mg (25–36% anthocyanins) (capsule) or 3 mL (tincture; ≈ 60 drops)

  • Form & Preparation: Capsule or tincture

  • Timing: With meals

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: May increase bleeding risk—use caution with blood thinners and stop 7 days before surgery; may modestly lower blood sugar—monitor if using diabetes medications; possible stomach upset or headache; discontinue if hypersensitivity.


5. Beta Carotene Extract 🔗 (view details)

  • Function: Beta carotene acts as an antioxidant that protects the retina and macula from free radical damage. Though it’s not recommended for smokers, non-smokers may benefit from its ability to reduce oxidative stress and support eye health.

  • Recommended Dose: 3–6 mg/day

  • Therapeutic Dose: Up to 15 mg/day

  • Form: Softgel or capsule

  • Timing: With meals

  • Duration: Ongoing

  • Cautions & Safety Notes: High-dose beta-carotene has been linked to increased lung cancer risk in current/former smokers or with asbestos exposure—avoid high doses in these groups; may cause benign yellow-orange skin discoloration; avoid combining with high-dose vitamin A or retinoid medicines; seek guidance with liver disease.

Indirect Support

(Most Helpful → Least Helpful)

These extracts do not act directly on macular degeneration but may support circulation, reduce oxidative stress, or enhance overall visual function.

1. Curcumin 🔗 (view details)

  • Function: Curcumin, known for its anti-inflammatory properties, helps combat oxidative stress in the retina. Its protective role in retinal cells supports long-term eye function and helps prevent damage to sensitive tissues.

  • Recommended Dose: 500–1,000 mg

  • Therapeutic Dose: Up to 1,500 mg

  • Form & Preparation: Capsule

  • Timing: With meals

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: May increase bleeding risk—use caution with blood thinners and stop 1–2 weeks before surgery; avoid in bile duct obstruction and use caution with gallstones; may lower blood sugar—monitor if using diabetes medicines; black pepper extracts (piperine) can increase absorption and affect medicine levels; possible stomach upset or reflux.


2. Chlorella 🔗 (view details)

  • Function: Chlorella contains lutein, zeaxanthin, and chlorophyll, all of which support eye health. Though research is limited, its antioxidant profile aligns with known AMD protection pathways.

  • Recommended Dose: 2,000–3,000 mg/day (powder ≈ 2/3–1 tsp)

  • Therapeutic Dose: Up to 6,000 mg/day (powder ≈ 2 tsp)

  • Form: Tablet or powder

  • Timing: With meals

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: High vitamin K may reduce warfarin effect; start low to minimize GI upset (bloating, loose stools); rare hypersensitivity—discontinue if rash or significant irritation.


3. Spirulina 🔗 (view details)

  • Function: Spirulina is rich in zeaxanthin, beta-carotene, and antioxidants, and may support retinal health by reducing oxidative stress, while also benefiting overall eye health and visual acuity.

Alternative Treatments

These alternative therapies support visual preservation, promote eye tissue resilience, and help slow progression in individuals with macular degeneration.

1. Red Light Therapy 🔗 (view details)

  • Function: Red light therapy uses controlled wavelengths of red and near-infrared light to improve retinal mitochondrial function and may help slow visual deterioration in early AMD.

  • Safe & Effective Eye protection; 620–670 nm; clean, dry skin; 10–20 cm distance; 5–15 min per area; follow device max time

  • Session Frequency: 3–5 sessions/week

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Do not shine into eyes; photosensitizing medicines/conditions require clinician guidance; stop if burning, blistering, or headache occurs; avoid use over known skin cancers.


2. Acupuncture 🔗 (view details)

  • Function: Acupuncture may improve visual health by stimulating points like BL1 (Jingming), at the inner corner of the eye, and ST2 (Sibai), just below the eye socket, to boost circulation and reduce pressure. Additionally, GB20 (Fengchi), at the base of the skull, helps relieve tension and support overall eye function.

  • Safe & Effective Use: Licensed practitioner; sterile single-use needles; 30 min/session.

  • Session Frequency: 1–2 sessions/week

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Increased bleeding risk—use caution with anticoagulants or bleeding disorders; avoid needling over infection, open wounds, or active rash; pregnancy—avoid contraindicated points; implanted devices—avoid electroacupuncture over pacemakers/ICDs; recent surgery or lymphedema—practitioner guidance required.


3. Ayurveda 🔗 (view details)

  • Function: Ayurveda supports visual health through herbs like triphala, turmeric, and ashwagandha, which offer strong antioxidant protection. Practices such as Netra Tarpana and specific dietary adjustments are traditionally used to maintain healthy vision and eye function.

  • Safe & Effective Use: Initial consult; individualized diet and herb plan; daily routine

  • Session Frequency: Daily home practice; practitioner follow-up every 2–4 weeks

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: Herb–drug interactions are possible—ask your doctor or pharmacist. Use quality-controlled products tested for heavy metals. Intensive detox (Panchakarma) needs clinician supervision due to dehydration/electrolyte risks. Stop herbal formulas 7 days before surgery if they may affect bleeding. Discontinue if hypersensitivity.


4. Eye Exercises

  • Function: Eye exercises are primarily anecdotal practices that aim to stimulate visual processing and eye-muscle coordination, and may help slow decline or improve contrast sensitivity in early-stage AMD.

Global Safety Note

ℹ️ Guidance Note
Not a protocol—each supplement is listed individually with references; anecdotes are flagged
 

Introduce gradually
 

  • Start with one supplement

  • Add one new supplement every 3–7 days if tolerated

  • Keep ≤3 changes at once
     

Stacking rules
 

  • Don’t combine supplements with the same primary Effect

  • Use only listed synergies; avoid antagonisms or separate by the stated time

  • Track total exposure when items share an active or pathway (e.g., melatonin, zinc)


Use Window
 

  • Respect each item’s Timing and Duration caps

  • Stop early once goals are met; re-evaluate at 8–12 weeks

  • See Global Safety Note below

ℹ️ Guidance Note
Not a protocol—each natural compound is listed individually with references; anecdotes are flagged
 

Introduce gradually
 

  • Start with one natural compound

  • Add one new compound every 3–7 days if tolerated

  • Keep ≤2 changes at once
     

Stacking rules
 

  • Don’t combine compounds with the same primary Effect

  • Use only listed synergies; avoid antagonisms or separate by the stated time

  • Track total exposure when compounds share an active or pathway (e.g., organic acids like ACV, alkalizers like sodium bicarbonate, metal ions like colloidal silver)


Use Window
 

  • Respect each item’s Timing and Duration caps

  • Always patch-test topical applications

  • Do not layer potential irritants on the same area

  • Stop at first signs of irritation or intolerance

  • See Global Safety Note below

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Direct / Indirect Support 

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Direct / Indirect Support 

(Most Helpful → Least Helpful)

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Functional Lab Tests You May Wish to Explore

Currently, no functional lab tests aligned with our integrative and natural health standards are available for this condition. Once reliable tests are identified and validated, we will review and feature them here.

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Books Worth Considering for Deeper Insight

ancestral-dietary-strategy-to-prevent-and-treat-macular-degeneration-book
See Book

Ancestral Dietary Strategy to Prevent and Treat Macular Degeneration

eat-right-for-your-sight-book
See Book

Eat Right for Your Sight

how-i-beat-macular-degeneration-in-the-early-stages-and-how-you-can-too-book
See Book

How I Beat Macular Degeneration in the Early Stages

overcoming-macular-degeneration-book
See Book

Overcoming Macular Degeneration

stop-vision-loss-now-book
See Book

Stop Vision Loss Now!

the-eye-care-revolution-book
See Book

The Eye Care Revolution

what-you-must-know-about-age-related-macular-degeneration-book
See Book

What You Must Know About Age-Related Macular Degeneration

Currently, no high-quality books meeting our functional, integrative, and natural healing standards are available for this condition. As soon as trusted resources are published, we will review and feature them here.

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Podcasts That Offer Valuable Perspectives

Currently, no high-quality podcast episodes meeting our functional, integrative, and natural healing standards are available for this condition. We will review and feature trusted resources here as soon as they become available.

natural-eye-care-with-dr-marc-grossman-holistic-optometrist-podcast-cover
See Episode

Herbs for Macular Degeneration and Diabetic Retinopathy

natural-eye-care-with-dr-marc-grossman-holistic-optometrist-podcast-cover
See Episode

How to Help Prevent Macular Degeneration

the-well-mans-podcast-cover
See Episode

Macular Degeneration: Age-Related Eyesight Changes

the-jazzy-eyes-podcast-cover
See Episode

Navigating Macular Degeneration

dishing-up-nutrition-podcast-cover
See Episode

Nutritional Support for Macular Degeneration

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Educational Videos To Learn From

Currently, no high-quality podcast episodes meeting our functional, integrative, and natural healing standards are available for this condition. We will review and feature trusted resources here as soon as they become available.

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How Key Nutrients Support the Body

Amino Acids: Amino acids serve as the building blocks of proteins, crucial for muscle growth and repair. Additionally, they play key roles in maintaining proper pH levels, storing nitrogen, synthesizing hormones, and facilitating enzymatic reactions.


Antioxidants: Antioxidants protect cells from oxidative stress caused by free radicals, potentially reducing the risk of chronic diseases such as cancer and cardiovascular ailments. They safeguard DNA integrity, slow down aging processes, and support overall cellular health.


Enzymes and Coenzymes: Enzymes catalyze biochemical reactions, while coenzymes assist in these processes by binding temporarily to enzymes. Together, they regulate digestion, energy production, immune responses, and various metabolic pathways.


Fatty Acids: Fatty acids serve as energy sources, structural components of cell membranes, and precursors to signaling molecules. Essential fatty acids, like omega-3 and omega-6, play critical roles in brain function, cardiovascular health, and inflammation regulation.


Fruit Extracts: Rich in antioxidants, vitamins, and fiber, fruit extracts offer numerous health benefits, including anti-inflammatory, anti-cancer, and immune-boosting properties. They also support digestive health and contribute to overall well-being.


Herbal Extracts: Herbal extracts contain bioactive compounds with various medicinal properties, including antioxidant, anti-inflammatory, and antimicrobial effects. They have been used traditionally to support digestion, immunity, and overall health.


Minerals: Minerals are essential for various physiological functions, including bone health, nerve transmission, and enzyme activity. They support overall health by ensuring proper cellular function and metabolic processes.


Other Nutrients: Other nutrients encompass a wide array of essential compounds crucial for various physiological functions. This category includes neurotransmitters and their precursors, which facilitate nerve signaling and are vital for central nervous system function. Additionally, naturally occurring structural components and biological detergents, such as phospholipids and bile salts, play critical roles in tissue repair, fat digestion, and overall bodily function. Phospholipids contribute to cell membrane integrity and fat emulsification, while bile salts are key to digesting and absorbing dietary fats. Hormones and their precursors regulate numerous physiological processes, including metabolism, growth, and reproduction. Furthermore, naturally occurring chemicals and metals play pivotal roles in enzymatic reactions, immune function, and overall health maintenance.


Vitamins: Vitamins are essential micronutrients that play diverse roles in supporting cellular processes, immune function, and overall health. They must be obtained through diet or supplementation to ensure proper bodily function.

Essential Nutrients Explained

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References

[1] Alves-Rodrigues A, Shao A. The science behind lutein. Toxicol Lett. 2004;150(1):57-83.
[2] Feng L, Nie K, Jiang H, Fan W. Effects of lutein supplementation in age-related macular degeneration. PLoS One. 2019;14(12):e0227048. Published 2019 Dec 30.
[3] Liu R, Wang T, Zhang B, et al. Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014;56(1):252-258. Published 2014 Dec 16.
[4] Zhao L, Sweet BV. Lutein and zeaxanthin for macular degeneration. Am J Health Syst Pharm. 2008;65(13):1232-1238.
[5] Age-Related Eye Disease Study 2 (AREDS2) Research Group, Chew EY, Clemons TE, et al. Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3. JAMA Ophthalmol. 2014;132(2):142-149.
[6] Gale CR, Hall NF, Phillips DI, Martyn CN. Lutein and zeaxanthin status and risk of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2003;44(6):2461-2465.
[7] Granado F, Olmedilla B, Blanco I. Nutritional and clinical relevance of lutein in human health. Br J Nutr. 2003;90(3):487-502.
[8] Bone RA, Landrum JT, Guerra LH, Ruiz CA. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans [published correction appears in J Nutr. 2003 Jun;133(6):1953]. J Nutr. 2003;133(4):992-998.
[9] Eisenhauer B, Natoli S, Liew G, Flood VM. Lutein and Zeaxanthin—Food Sources, Bioavailability and Dietary Variety in Age‐Related Macular Degeneration Protection. Nutrients. 2017; 9(2):120.
[10] Lem DW, Davey PG, Gierhart DL, Rosen RB. A Systematic Review of Carotenoids in the Management of Age-Related Macular Degeneration. Antioxidants (Basel). 2021;10(8):1255. Published 2021 Aug 5.
[11] Ma L, Dou HL, Wu YQ, et al. Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. Br J Nutr. 2012;107(3):350-359.
[12] Ma L, Yan SF, Huang YM, et al. Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration. Ophthalmology. 2012;119(11):2290-2297.
[13] Fursova AZh, Gesarevich OG, Gonchar AM, Trofimova NA, Kolosova NG. Adv Gerontol. 2005;16:76-79.
[14] Wang Y, Zhao L, Lu F, et al. Retinoprotective Effects of Bilberry Anthocyanins via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Mechanisms in a Visible Light-Induced Retinal Degeneration Model in Pigmented Rabbits. Molecules. 2015;20(12):22395-22410. Published 2015 Dec 14.
[15] Osada H, Okamoto T, Kawashima H, et al. Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina. PLoS One. 2017;12(6):e0178627. Published 2017 Jun 1.
[16] Wang Y, Zhao L, Lu F, et al. Retinoprotective Effects of Bilberry Anthocyanins via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Mechanisms in a Visible Light-Induced Retinal Degeneration Model in Pigmented Rabbits. Molecules. 2015;20(12):22395-22410. Published 2015 Dec 14.
[17] Chu W, Cheung SCM, Lau RAW, et al. Bilberry (Vaccinium myrtillus L.) In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 4.
[18] Huang WY, Wu H, Li DJ, et al. Protective Effects of Blueberry Anthocyanins against H2O2-Induced Oxidative Injuries in Human Retinal Pigment Epithelial Cells. J Agric Food Chem. 2018;66(7):1638-1648.
[19] Castelli V, Paladini A, d'Angelo M, et al. Taurine and oxidative stress in retinal health and disease. CNS Neurosci Ther. 2021;27(4):403-412.
[20] Tao Y, He M, Yang Q, et al. Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments. Drug Des Devel Ther. 2019;13:2689-2702. Published 2019 Aug 7.
[21] Froger N, Cadetti L, Lorach H, et al. Taurine provides neuroprotection against retinal ganglion cell degeneration. PLoS One. 2012;7(10):e42017.
[22] Hayes KC, Carey RE, Schmidt SY. Retinal degeneration associated with taurine deficiency in the cat. Science. 1975;188(4191):949-951.
[23] Lombardini JB. Taurine: retinal function. Brain Res Brain Res Rev. 1991;16(2):151-169.
[24] Chew EY, Clemons TE, Agrón E, et al. Long-term effects of vitamins C and E, ß-carotene, and zinc on age-related macular degeneration: AREDS report no. 35 [published correction appears in Ophthalmology. 2016 Dec;123(12 ):2634]. Ophthalmology. 2013;120(8):1604-11.e4.
[25] Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8 [published correction appears in Arch Ophthalmol. 2008 Sep;126(9):1251]. Arch Ophthalmol. 2001;119(10):1417-1436.
[26] van Leeuwen R, Boekhoorn S, Vingerling JR, et al. Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA. 2005;294(24):3101-3107.
[27] Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group [published correction appears in JAMA 1995 Feb 22;273(8):622]. JAMA. 1994;272(18):1413-1420.
[28] Lim JC, Caballero Arredondo M, Braakhuis AJ, Donaldson PJ. Vitamin C and the Lens: New Insights into Delaying the Onset of Cataract. Nutrients. 2020;12(10):3142. Published 2020 Oct 14.
[29] Antioxidant Status and Neovascular Age-Related Macular Degeneration. Arch Ophthalmol. 1993;111(1):104–109.
[30] Wong, I.Y.H., Koo, S.C.Y. & Chan, C.W.N. Prevention of age-related macular degeneration. Int Ophthalmol 31, 73–82 (2011).
[31] Snodderly DM. Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr. 1995;62(6 Suppl):1448S-1461S.
[32] SanGiovanni JP, Chew EY, Agrón E, et al. The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23. Arch Ophthalmol. 2008;126(9):1274-1279.
[33] Merle BM, Benlian P, Puche N, et al. Circulating omega-3 Fatty acids and neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014;55(3):2010-2019. Published 2014 Mar 28.
[34] Souied EH, Aslam T, Garcia-Layana A, et al. Omega-3 Fatty Acids and Age-Related Macular Degeneration. Ophthalmic Res. 2015;55(2):62-69.
[35] Jiang H, Shi X, Fan Y, et al. Dietary omega-3 polyunsaturated fatty acids and fish intake and risk of age-related macular degeneration. Clin Nutr. 2021;40(12):5662-5673.
[36] Prokopiou E, Kolovos P, Kalogerou M, et al. Therapeutic potential of omega-3 fatty acids supplementation in a mouse model of dry macular degeneration. BMJ Open Ophthalmology 2017;1:e000056.
[37] McCarty MF. The putative therapeutic value of high-dose selenium in proliferative retinopathies may reflect down-regulation of VEGF production by the hypoxic retina. Med Hypotheses. 2005;64(1):159-161.
[38] Ananth S, Miyauchi S, Thangaraju M, et al. Selenomethionine (Se-Met) Induces the Cystine/Glutamate Exchanger SLC7A11 in Cultured Human Retinal Pigment Epithelial (RPE) Cells: Implications for Antioxidant Therapy in Aging Retina. Antioxidants (Basel). 2020;10(1):9. Published 2020 Dec 24.
[39] Vishwanathan R, Chung M, Johnson EJ. A systematic review on zinc for the prevention and treatment of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2013;54(6):3985-3998. Published 2013 Jun 12.
[40] Blasiak J, Pawlowska E, Chojnacki J, Szczepanska J, Chojnacki C, Kaarniranta K. Zinc and Autophagy in Age-Related Macular Degeneration. Int J Mol Sci. 2020;21(14):4994. Published 2020 Jul 15.
[41] Smailhodzic D, van Asten F, Blom AM, et al. Zinc supplementation inhibits complement activation in age-related macular degeneration. PLoS One. 2014;9(11):e112682. Published 2014 Nov 13.
[42] Erie JC, Good JA, Butz JA, Pulido JS. Reduced zinc and copper in the retinal pigment epithelium and choroid in age-related macular degeneration. American journal of ophthalmology. 2009 Feb 1;147(2):276-82.
[43] Flinn JM, Kakalec P, Tappero R, Jones B, Lengyel I. Correlations in distribution and concentration of calcium, copper and iron with zinc in isolated extracellular deposits associated with age-related macular degeneration. Metallomics. 2014 Jul;6(7):1223-8.
[44] Garcia Layana A, Minnella AM, Garhöfer G, Aslam T, Holz FG, Leys A, Silva R, Delcourt C, Souied E, Seddon JM. Vitamin D and age-related macular degeneration. Nutrients. 2017 Oct 13;9(10):1120.
[45] Millen AE, Meyers KJ, Liu Z, Engelman CD, Wallace RB, LeBlanc ES, Tinker LF, Iyengar SK, Robinson JG, Sarto GE, Mares JA. Association between vitamin D status and age-related macular degeneration by genetic risk. JAMA ophthalmology. 2015 Oct 1;133(10):1171-9.
[46] Sun YD, Dong YD, Fan R, Zhai LL, Bai YL, Jia LH. Effect of (R)-α-lipoic acid supplementation on serum lipids and antioxidative ability in patients with age-related macular degeneration. Annals of Nutrition and Metabolism. 2012 Jun 1;60(4):293-7.
[47] Tao Y, Jiang P, Wei Y, Wang P, Sun X, Wang H. α-Lipoic acid treatment improves vision-related quality of life in patients with dry age-related macular degeneration. The Tohoku journal of experimental medicine. 2016;240(3):209-14.
[48] Terluk MR, Ebeling MC, Fisher CR, Kapphahn RJ, Yuan C, Kartha RV, Montezuma SR, Ferrington DA. N‐Acetyl‐L‐cysteine Protects Human Retinal Pigment Epithelial Cells from Oxidative Damage: Implications for Age‐Related Macular Degeneration. Oxidative medicine and cellular longevity. 2019;2019(1):5174957.
[49] de Almeida Torres RJ, dos Anjos Ferreira AL, Luchini A, de Almeida Torres RJ, Correa CR. The role of non-enzymatic antioxidants on age-related macular degeneration. Front. Drug Chem. Clin. Res. 2022 Jan 6;5:1-9.
[50] Blasi MA, Bovina C, Carella G, Genova ML, Jansen A, Lenaz G, Brancato R. Does coenzyme Q10 play a role in opposing oxidative stress in patients with age-related macular degeneration?. Ophthalmologica. 2001 Feb 1;215(1):51-4.
[51] Zhang X, Tohari AM, Marcheggiani F, Zhou X, Reilly J, Tiano L, Shu X. Therapeutic potential of co-enzyme Q10 in retinal diseases. Current medicinal chemistry. 2017 Dec 1;24(39):4329-39.
[52] Lem DW, Davey PG, Gierhart DL, Rosen RB. A systematic review of carotenoids in the management of age-related macular degeneration. Antioxidants. 2021 Aug 5;10(8):1255.
[53] Van Leeuwen R, Boekhoorn S, Vingerling JR, Witteman JC, Klaver CC, Hofman A, de Jong PT. Dietary intake of antioxidants and risk of age-related macular degeneration. Jama. 2005 Dec 28;294(24):3101-7.
[54] Alugoju P, Krishna Swamy VK, Anthikapalli NV, Tencomnao T. Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review. Critical Reviews in Food Science and Nutrition. 2023 Dec 10;63(31):10709-74.
[55] Bjørklund G, Gasmi A, Lenchyk L, Shanaida M, Zafar S, Mujawdiya PK, Lysiuk R, Antonyak H, Noor S, Akram M, Smetanina K. The role of astaxanthin as a nutraceutical in health and age-related conditions. Molecules. 2022 Oct 23;27(21):7167.
[56] Vallée A. Curcumin and Wnt/β‑catenin signaling in exudative age‑related macular degeneration. International Journal of Molecular Medicine. 2022 Jun 1;49(6):1-3.
[57] Allegrini D, Raimondi R, Angi M, Ricciardelli G, Montericcio A, Borgia A, Romano MR. Curcuma-based nutritional supplement in patients with neovascular age-related macular degeneration. Journal of Medicinal Food. 2021 Nov 1;24(11):1191-6.
[58] Krenn H. Acupuncture may improve vision in patients with age-related macular degeneration (AMD): An observational study. Deutsche Zeitschrift für Akupunktur. 2008 Jan 1;51(3):25-8.
[59] Lundgren AC. An acupuncture protocol for treatment of age-related macular degeneration: a second report. Medical Acupuncture. 2005;16(3):33-5.
[60] Ayurvedic medicine promotes eye health through herbs like Triphala, Turmeric (curcumin), and Ashwagandha for their antioxidant properties. Practices such as Netra Tarpana (using medicated ghee for the eyes) and dietary adjustments are also emphasized to support overall ocular wellness.
[61] Kumar M. The management of age-related macular degeneration (ARMD) in Ayurvedic perspective - A critical review. Int. J. Ayur. Pharma Research. 2015;3(3):8-12.
[62] WeISS JN. Hyperbaric oxygen therapy and age-related macular degeneration. Undersea & Hyperbaric Medicine. 2010 Mar 1;37(2):101.
[63] Merle BM, Barthes S, Féart C, Cougnard-Grégoire A, Korobelnik JF, Rougier MB, Delyfer MN, Delcourt C. B vitamins and incidence of advanced age-related macular degeneration: the Alienor study. Nutrients. 2022 Jul 8;14(14):2821.
[64] Christen WG, Glynn RJ, Chew EY, Albert CM, Manson JE. Folic acid, vitamin B6, and vitamin B12 in combination and age-related macular degeneration in a randomized trial of women. Archives of internal medicine. 2009 Feb 23;169(4):335.
[65] Broadhead GK, Grigg J, McCluskey PJ, Hong T, Schlub TE, Chu E, Chang AA. Saffron therapy for the ongoing treatment of age-related macular degeneration. BMJ Open Ophthalmology. 2024 Mar 13;9(1).
[66] Broadhead GK, Grigg JR, McCluskey P, Hong T, Schlub TE, Chang AA. Saffron therapy for the treatment of mild/moderate age-related macular degeneration: a randomised clinical trial. Graefe's Archive for Clinical and Experimental Ophthalmology. 2019 Jan 28;257:31-40.
[67] Kim KA, Cha KH, Choi SJ, Pan CH, Jung SH. The extract of Chlorella vulgaris protects transformed retinal ganglion cells from oxidative stress‐induced cells death. Journal of Food Biochemistry. 2014 Apr;38(2):129-39.
[68] Yu HY, Cho DH, Seo D, Yoo C, Park SB, Jung WK, Jung JE, Kim HS, Kim J. Microalga Chlorella sp. biomass containing high lutein prevents light-induced photooxidation and retinal degeneration in mice. Algal Research. 2024 Aug 1;82:103620.
[69] Okamoto T, Kawashima H, Osada H, Toda E, Homma K, Nagai N, Imai Y, Tsubota K, Ozawa Y. Dietary spirulina supplementation protects visual function from photostress by suppressing retinal neurodegeneration in mice. Translational Vision Science & Technology. 2019 Nov 1;8(6):20-.
[70] Lixi F, Vitiello L, Giannaccare G. Marine natural products rescuing the eye: A narrative review. Marine Drugs. 2024 Mar 28;22(4):155.
[71] Sivapathasuntharam C, Sivaprasad S, Hogg C, Jeffery G. Aging retinal function is improved by near infrared light (670 nm) that is associated with corrected mitochondrial decline. Neurobiol Aging. 2017;52:66-70.
[72] Nassisi M, Mainetti C, Paparella GR, Belloni Baroni L, Milella P, Leone G, Galli D, Pozzo Giuffrida F, Dell’Arti L, Mapelli C, Casalino G. Short-term efficacy of photobiomodulation in early and intermediate age-related macular degeneration: the PBM4AMD study. Eye. 2024 Dec;38(18):3467-72.

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