top of page

Essential4Health

Evidence-based natural health

Essential4Health

Evidence-based natural health

senior-man-standing-living-room-holding-hand-lower-back-chronic-pain
"Chronic Pain" is a lasting condition defined by persistent discomfort that continues for six months or more. It may stem from nerve damage, injury, illness, or inflammation and often affects areas like the back, joints, or head. The pain can disrupt sleep, mood, and daily functioning. Treatment often involves physical therapy, medication, stress management, or holistic options like acupuncture. Addressing both physical and emotional aspects is key to improving daily comfort and managing symptoms long-term.

Description

This page has 70 references

"Chronic Pain" is a lasting condition defined by persistent discomfort that continues for six months or more. It may stem from nerve damage, injury, illness, or inflammation and often affects areas like the back, joints, or head. The pain can disrupt sleep, mood, and daily functioning. Treatment often involves physical therapy, medication, stress management, or holistic options like acupuncture. Addressing both physical and emotional aspects is key to improving daily comfort and managing symptoms long-term.

Symptoms & Signs

Burning Sensation, Pain, Shooting, Squeezing, Stiffness, Stinging, Throbbing

medical-practitioner-checking-health-status-patient-blood-pressure-check-essential4health

Chronic Pain

Body System

Brain and Nerves, General

Causes

Past Injury, Chronic Inflammation, Musculoskeletal Imbalance, Nerve Damage, Underlying Illness, Psychological Trauma

Things To Do

It is important to focus on proper nutrition when suffering from chronic pain. It includes:


  • a whole-foods-based diet that includes vegetables, fruits, whole grains, protein, and fatty acids from plant and animal products.

  • large amounts of anti-inflammatory foods, such as various types of fish, leafy green vegetables, broccoli, berries, healthy fats [from avocados, walnuts, almonds, extra virgin olive oil, extra virgin coconut oil, grass-fed butter, ghee], turmeric, ginger, garlic, etc.

  • probiotic foods, such as unprocessed and unsweetened yogurt, kefir, sauerkraut, komchi, etc.

  • prebiotic foods, such as leeks, chicory root, onions, garlic, asparagus, apples, bananas, flax seeds, etc.

  • applying a low-carbohydrate diet that reduces inflammation, nervous system sensitivity, and oxidative stress.

  • hot spices, such as cayenne pepper and chili peppers, which have anti-inflammatory constituents and can help manage pain.

  • taking care of sufficient hydration by drinking mineral water and herbal teas.

  • intermittent fasting, which is known to diminish the inflammatory state and oxidative stress.


Other techniques that can help with chronic pain include:


  • regular physical activity that does not cause additional pain.

  • ruling out any allergies that can contribute to the recurring pain sensation.

  • quality sleep.

  • outdoor time.

  • breathing exercises.

  • using natural painkillers, such as essential oils.

  • Depending on the type of pain, consider massage, acupressure, or acupuncture.

  • maintaining a healthy body weight.

Things To Avoid

Dietary don'ts in chronic pain include:


  • sugar, sugary snacks, desserts, baked goods, sweet drinks, and beverages. Sugar is highly inflammatory and can cause damage to the internal organs.

  • artificial sweeteners, e.g., in sodas.

  • white flour in breads and pasta.

  • commercially available sauces and condiments.

  • AGEs [advanced glycation end products] in cooking give grilled and fried foods the browned and smokey look and flavor.

  • MSG [monosodium glutamate] and other flavor enhancers

  • Processed foods and junk foods are high in trans fats, added sugar, refined carbohydrates, salt, and preservatives.

  • oxidizing vegetable oils used in cooking, such as sunflower, canola, and safflower. They aggravate inflammation.

  • alcohol.


Other unhelpful habits and choices include:


  • smoking.

  • being overweight and obese.

  • physical inactivity.

  • lack of sufficient sleep.

  • stress.

  • sendentary lifestyle.

Already a Subscriber? Log In

See a fully unlocked page

Already a Subscriber? Log In

See a fully unlocked page

ℹ️ Guidance Note
Not a protocol—each modality is listed individually with references; anecdotes are flagged
 

Usage rules
 

  • Use one modality per session within the listed frequency and duration

  • Add new modalities one at a time, week by week

  • Stop immediately if adverse symptoms occur
     

Combining rules
 

  • Combine modalities only if explicitly allowed in the entry

  • Avoid overlapping heat or intensive manual therapies on the same day unless specified

  • Use only listed synergies; otherwise do not combine in the same session


Professional Care
 

  • Follow the fixed safe-use lines where indicated (e.g., acupuncture requires a licensed practitioner)

  • See Global Safety Note below

ℹ️ Guidance Note
Not a protocol—each plant active is listed individually with references; anecdotes are flagged
 

Introduce gradually
 

  • Start with one plant active

  • Add one new plant active every 7 days if tolerated

  • Keep ≤2 changes at once
     

Stacking rules
 

  • Avoid combining herbs with the same primary Effect

  • Always check for drug–herb interactions and photosensitivity

  • Use only listed synergies; avoid antagonisms or separate by the stated time


Use Window
 

  • Respect each item’s Timing and Duration caps

  • Patch-test topicals and dilute essential oils to the listed %

  • See Global Safety Note below

Clinician-managed


These options do not replace prescribed care. “Therapeutic Dose” denotes the upper limit (“Up to …”), and “Duration” denotes the Safe Duration cap — at the Recommended Dose you may continue or cycle beyond this window if symptoms persist and no adverse effects occur; at the Therapeutic Dose do not extend without clinician oversight. A clinician may extend or cycle beyond this window with clinical justification. Coordinate changes, lab-guided dosing, cycling, and peri-procedure holds with your clinician, and review drug–nutrient interactions. Use quality-tested products; patch test topicals; dilute essential oils; avoid eyes/mucosa.

Already a Subscriber? Log In

See a fully unlocked page

Supplements

Direct Support

(Most Helpful → Least Helpful)

These supplements directly affect chronic pain by modulating pain signaling pathways, reducing inflammation, or supporting nerve function.

1. Benfotiamine 🔗 (view details)

  • Function: Benfotiamine improves nerve function and helps reduce pain associated with neuropathy by increasing nerve conduction and lowering HbA1c levels, making it effective for managing chronic neuropathic pain.

  • Recommended Dose: 300 mg/day

  • Therapeutic Dose: Up to 600 mg/day

  • Form: Tablet or capsule

  • Timing: With meals

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: Count total thiamine (B1) from multivitamins/B-complex to avoid unnecessary excess; monitor glucose (especially with antidiabetic medications); GI upset or rash possible.


2. Alpha-Lipoic Acid 🔗 (view details)

  • Function: Alpha-lipoic acid reduces nerve-related pain by lowering oxidative stress and improving mitochondrial function in damaged tissues.

  • Recommended Dose: 300–600 mg/day

  • Therapeutic Dose: Up to 1,200 mg/day

  • Form: Capsule or tablet

  • Timing: Empty stomach

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: May lower blood glucose—monitor if using antidiabetic drugs; caution in thyroid disorders; ensure thiamine sufficiency (alcohol misuse, malnutrition); avoid during chemotherapy/radiation unless clinician-approved; GI upset or insomnia possible.


3. S-Adenosylmethionine [SAMe] 🔗 (view details)

  • Function: SAMe supports joint comfort and mood balance by promoting anti-inflammatory pathways and aiding neurotransmitter synthesis.

  • Recommended Dose: 400–800 mg/day

  • Therapeutic Dose: Up to 1,600 mg/day

  • Form: Enteric-coated tablet

  • Timing: Empty stomach

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: Avoid with SSRIs, MAOIs, and other serotonergic agents (serotonin syndrome risk); avoid in bipolar disorder or history of mania/hypomania; may cause nausea, anxiety, or insomnia; may raise homocysteine—ensure adequate B12 and folate.


4. Magnesium 🔗 (view details)

  • Function: Magnesium blocks NMDA receptors involved in pain transmission, reducing pain sensitivity and promoting muscle relaxation, making it effective for managing chronic pain.

  • Recommended Dose: 200–400 mg/day elemental (divided doses)

  • Therapeutic Dose: Up to 600 mg/day elemental (divided doses)

  • Form: Capsule or tablet

  • Timing: With meals

  • Duration: Ongoing

  • Cautions & Safety Notes: Diarrhea with citrate; caution in kidney disease.


5. Omega 3 🔗 (view details)

  • Function: Omega-3 fatty acids reduce pain by lowering inflammatory markers like cytokines, which are often elevated in chronic conditions. This helps alleviate pain and promote overall well-being.

  • Recommended Dose: 1,000–2,000 mg/day (EPA + DHA)

  • Therapeutic Dose: Up to 3,000 mg/day (EPA + DHA)

  • Form: Softgel or oil

  • Timing: With meals

  • Duration: Ongoing

  • Cautions & Safety Notes: May thin blood at higher doses; choose purified products.


6. Vitamin D 🔗 (view details)

  • Function: Vitamin D helps reduce inflammation and modulate immune responses, which are crucial in managing chronic pain. Adequate levels may help alleviate symptoms in conditions involving inflammatory pain.

  • Recommended Dose: 2,000–4,000 IU/day D3 + K2 MK-7 90–200 mcg/day

  • Therapeutic Dose: Up to 10,000 IU/day D3

  • Form: Softgel or liquid drops

  • Timing: With meals

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: Monitor 25(OH)D and calcium at higher intakes; avoid unsupervised high doses in granulomatous disease or primary hyperparathyroidism; caution with thiazides/digoxin; vitamin K2 may antagonize warfarin.

Indirect Support

(Most Helpful → Least Helpful)

These supplements do not target pain directly but may improve stress resilience, enhance sleep quality, or support tissue repair that contributes to pain reduction.

1. Coenzyme Q10 [CoQ10] 🔗 (view details)

  • Function: CoQ10 reduces chronic pain by supporting mitochondrial energy production and lowering inflammation in muscle and nerve tissues.

  • Recommended Dose: 100–200 mg/day

  • Therapeutic Dose: Up to 300 mg/day

  • Form: Softgel

  • Timing: With meals

  • Duration: Ongoing

  • Cautions & Safety Notes: May reduce warfarin effect (↓INR).

Natural Compounds

These natural compounds may help manage chronic pain by easing inflammation, supporting nerve health, or enhancing the body’s healing capacity.

1. CBD Oil 🔗 (view details)

  • Function: CBD oil interact with the endocannabinoid system to modulate pain perception, reduce inflammation, and offer relief in conditions like neuropathic pain, arthritis, and multiple sclerosis.

  • Typical Amount: 10–40 mg CBD/day (e.g., 0.25–1 mL depending on concentration; 1 mL ≈ 20 drops)

  • Form & Delivery Method: Capsule or fluid; sublingual liquid drops (hold 60–90 s before swallowing)

  • Timing: With meals

  • Frequency: 1–2 times/day

  • Cautions & Safety Notes: May cause drowsiness; do not drive until you know your response; may interact with medicines that carry “grapefruit” warnings (ask your clinician/pharmacist); may raise liver enzymes at higher doses—consider periodic testing if used long term; can lower blood pressure—stand slowly; additive sedation with alcohol, antihistamines, or sleep medicines; discontinue if rash, dizziness, or unusual fatigue.


2. Epsom Salt [Magnesium Sulfate] 🔗 (view details)

  • Function: Epsom salt baths are used to ease chronic muscle pain and stiffness by delivering magnesium through the skin and promoting muscle relaxation.

  • Typical Amount: Bath: 240,000–480,000 mg (240–480 g; ≈ 1–2 cups) in 60–80 L warm water; Foot soak: 60,000–120,000 mg (60–120 g; ≈ ¼–½ cup) in 3–4 L warm water

  • Form & Delivery Method: Topical; dissolve crystals in a warm bath or basin and soak 10–20 minutes

  • Timing: After cleansing

  • Frequency: 3–5 times/week (or as needed)

  • Cautions & Safety Notes: Do not use on open wounds, infections, or fresh surgical incisions; stop if skin irritation, itching, or rash; avoid very hot water (dizziness/dehydration risk); kidney disease or severe heart failure—limit/avoid long soaks; rinse tub/basin after use to prevent slips.

Plant Actives

Direct Support

(Most Helpful → Least Helpful)

These plant extracts directly support detoxification by stimulating liver enzymes, promoting bile flow, or enhancing natural elimination processes.

1. Curcumin 🔗 (view details)

  • Function: Curcumin alleviates pain by inhibiting inflammatory pathways like the COX-2 enzyme and NF-kB, which are responsible for inflammation in conditions like osteoarthritis and rheumatoid arthritis.

  • Recommended Dose: 500–1,000 mg

  • Therapeutic Dose: Up to 1,500 mg

  • Form & Preparation: Capsule

  • Timing: With meals

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: May increase bleeding risk—use caution with blood thinners and stop 1–2 weeks before surgery; avoid in bile duct obstruction and use caution with gallstones; may lower blood sugar—monitor if using diabetes medicines; black pepper extracts (piperine) can increase absorption and affect medicine levels; possible stomach upset or reflux.


2. Ginger Extract 🔗 (view details)

  • Function: Ginger extract reduces chronic pain by inhibiting inflammatory mediators like prostaglandins and leukotrienes, supporting joint and muscle relief.

  • Recommended Dose: 500–1,000 mg (capsule) or 1–2 mL (tincture; ≈ 20–40 drops)

  • Therapeutic Dose: Up to 1,500 mg (capsule) or 3 mL (tincture; ≈ 60 drops)

  • Form & Preparation: Capsule or tincture

  • Timing: With meals

  • Duration: 8–12 weeks

  • Cautions & Safety Notes: Heartburn possible in some—reduce dose or discontinue if reflux worsens; may increase bleeding risk—use caution with anticoagulants/antiplatelets; may lower blood sugar—monitor if using antidiabetic medicines; use caution with gallstones or biliary obstruction; stop 7 days before surgery; discontinue if hypersensitivity.


3. White Willow Bark 🔗 (view details)

  • Function: White willow bark contains salicin, similar to aspirin, providing natural pain relief for conditions like osteoarthritis and lower back pain.

  • Recommended Dose: 240–480 mg (15% salicin) (capsule) or 1–2 mL (tincture; ≈ 20–40 drops)

  • Therapeutic Dose: Up to 720 mg (15% salicin) (capsule) or 3 mL (tincture; ≈ 60 drops)

  • Form & Preparation: Capsule or tincture

  • Timing: With meals

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Salicylate allergy risk; increased bleeding—use caution with anticoagulants/antiplatelets; do not combine with aspirin or other NSAIDs due to additive effects; stomach upset possible; stop 7 days before surgery; avoid with active peptic ulcer or significant kidney disease.


4. Boswellia Serrata Extract 🔗 (view details)

  • Function: Boswellia serrata contains boswellic acids, which reduce inflammation and help alleviate pain in chronic conditions, improving function and quality of life.

  • Recommended Dose: 500–1,000 mg (≥65% boswellic acids)

  • Therapeutic Dose: Up to 1,500 mg (≥65% boswellic acids)

  • Form & Preparation: Capsule

  • Timing: With meals

  • Duration: 8–12 week

  • Cautions & Safety Notes: Possible GI upset or reflux; rare allergy or skin rash; may have additive effects with anti-inflammatory medicines; discontinue if irritation or hypersensitivity.


5. Devil's Claw Extract 🔗 (view details)

  • Function: Devil’s claw contains harpagosides, active compounds that reduce inflammation and alleviate pain, enhancing function in individuals with chronic pain.

  • Recommended Dose: 450–900 mg (2.5–3% harpagoside) (capsule) or 1–2 mL (tincture; ≈ 20–40 drops)

  • Therapeutic Dose: Up to 1,500 mg (2.5–3% harpagoside) (capsule) or 3 mL (tincture; ≈ 60 drops)

  • Form & Preparation: Capsule or tincture

  • Timing: With meals

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: May increase bleeding risk—use caution with anticoagulants/antiplatelets; stomach irritation/ulcer risk—avoid with active peptic ulcer; may lower blood sugar—monitor if using antidiabetic medicines; rare liver enzyme elevation; stop 7 days before surgery; discontinue if hypersensitivity.


6. Stinging Nettle Extract 🔗 (view details)

  • Function: Stinging nettle contains flavonoids and other compounds that provide pain-relieving and anti-inflammatory benefits, making it useful for managing chronic pain.

  • Recommended Dose: 360–600 mg

  • Therapeutic Dose: Up to 1,200 mg

  • Form & Preparation: Capsule

  • Timing: With meals

  • Duration: 8–24 weeks

  • Cautions & Safety Notes: May lower blood pressure or blood sugar—monitor if using antihypertensives or diabetes medications; possible additive diuretic effect; use caution with blood thinners; gastrointestinal upset or rash possible; discontinue if hypersensitivity.

Indirect Support

(Most Helpful → Least Helpful)

These extracts do not act directly on pain but may support recovery, improve circulation, or help regulate mood and stress, which influence pain perception.

No replicated and convincing research studies are available, and there is no anecdotal evidence supporting the effectiveness of this method.

Alternative Treatments

These alternative therapies support pain relief, reduce inflammation, and promote physical and emotional resilience in the context of chronic pain.

1. Acupuncture 🔗 (view details)

  • Function: Acupuncture promotes pain relief by stimulating points such as LI4 (Hegu) on the hand and ST36 (Zusanli) just below the knee, modulating nerve signals.

  • Safe & Effective Use: Licensed practitioner; sterile single-use needles; 30 min/session.

  • Session Frequency: 1–2 sessions/week

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Increased bleeding risk—use caution with anticoagulants or bleeding disorders; avoid needling over infection, open wounds, or active rash; pregnancy—avoid contraindicated points; implanted devices—avoid electroacupuncture over pacemakers/ICDs; recent surgery or lymphedema—practitioner guidance required.


2. Transcutaneous Electrical Nerve Stimulation [TENS] 🔗 (view details)

  • Function: TENS therapy uses low-voltage electrical currents to block pain signals, offering a non-invasive, drug-free way to manage pain.

  • Safe & Effective Use: Portable unit with adhesive pads; place pads around (not on) the painful area on clean, dry skin; set intensity to a strong, comfortable tingling (not painful); 20–30 min per area

  • Session Frequency: 5–7 sessions/week

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Do not use with a pacemaker/ICD or over the chest/neck; avoid over broken skin, open wounds, or numb areas; do not use while driving or sleeping; pregnancy—avoid abdomen/lower back unless clinician-approved; post-surgery—avoid direct placement over incisions/staples until cleared; abdominal pain (e.g., pancreatitis) requires clinician guidance; epilepsy or heart-rhythm disorders—use only with clinician advice.


3. Massage Therapy 🔗 (view details)

  • Function: Massage therapy reduces pain, inflammation, and muscle tension, improving muscle function and offering long-lasting relief from discomfort.

  • Safe & Effective Use: Licensed therapist; light to moderate pressure adjusted to comfort; 30–60 min/session

  • Safe & Effective Use: Licensed therapist; light to moderate pressure adjusted to comfort; 30–60 min/session

  • Session Frequency: 1–2 sessions/week

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Avoid over open wounds, active infection, burns, acute DVT, fresh fractures, or severe osteoporosis. Use gentle pressure with anticoagulants or bleeding disorders. Avoid deep abdominal work in acute abdominal pain. During acute gout flares avoid the inflamed joint. Reduced sensation (neuropathy) requires lighter pressure and monitoring.


4. Osteopathy 🔗 (view details)

  • Function: Osteopathy uses manual manipulation to relieve pain, improve circulation, and support musculoskeletal health, helping the body function optimally.

  • Safe & Effective Use: Assessment by a qualified osteopath/physician; gentle soft-tissue, muscle-energy, articulation, cranial/lymphatic work; stay within a comfortable range; do prescribed home exercises

  • Session Frequency: 1 session/week for 2–4 weeks, then every 2–4 weeks as needed

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Defer with acute fracture, severe osteoporosis with recent fragility fracture, active DVT, open wounds, or fever/infection. New numbness/weakness or loss of bowel/bladder control needs urgent medical evaluation.


5. Ozone IV 🔗 (view details)

  • Function: Ozone therapy modulates pain receptors and neurotransmitter levels, reducing discomfort and inflammation, which may help alleviate pain.

  • Safe & Effective Use: Licensed clinician; sterile closed-circuit methods (e.g., major autohemotherapy or ozonated saline) per protocol; medical-grade oxygen; calibrated device

  • Session Frequency: 1–2 sessions/week

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Do not inject ozone gas directly into a vein (embolism risk). Avoid inhaling ozone (lung irritation). Stop and seek care for chest pain, shortness of breath, dizziness, severe vein irritation, or faintness. Chronic lung disease requires strict avoidance of airway exposure.


6. Hyperbaric Chamber Therapy 🔗 (view details)

  • Function: Hyperbaric oxygen therapy reduces inflammation, enhances tissue regeneration, and increases oxygen levels in the blood, supporting healing and pain relief over time.

  • Safe & Effective Use: Certified chamber with trained staff; 1.5–2.0 ATA; 60–90 min sessions with scheduled air breaks; follow facility rules (no petroleum products, electronics, or open flames)

  • Session Frequency: 3–5 sessions/week

  • Duration: 2–6 weeks

  • Cautions & Safety Notes: Do not use with untreated collapsed lung. Equalize often; postpone if congested. Claustrophobia: request a clear chamber and two-way comms; agree on a stop signal. Severe COPD/CO₂ retention, recent ear surgery, or fever—clinician clearance. Tell staff about chemo or lung disease.


7. Yoga 🔗 (view details)

  • Function: Yoga alleviates pain by improving flexibility, reducing muscle tension, and enhancing circulation. Through its calming effect on the nervous system and the release of endorphins, yoga promotes physical and mental well-being.

  • Safe & Effective Use: Begin with gentle Hatha or restorative sequences; steady nasal breathing; smooth, pain-free range; slow transitions; neutral spine; no forcing end range

  • Session Frequency: 3–5 sessions/week

  • Duration: Ongoing

  • Cautions & Safety Notes: Stop with pain, numbness, dizziness, or visual changes. Unstable cardiac or uncontrolled blood pressure—keep intensity low and avoid breath-holding. Osteoporosis—limit deep forward flexion and strong spinal twists. Glaucoma—avoid prolonged inversions. Hernia/hiatal hernia—avoid high intra-abdominal pressure.


8. Tai Chi 🔗 (view details)

  • Function: Tai chi combines gentle movements and breathing techniques to reduce pain, enhance mobility, and promote relaxation, supporting overall physical and mental health.

  • Safe & Effective Use: Qualified instructor or trusted video course; slow, controlled forms; neutral spine; smooth nasal breathing; supportive flat shoes or barefoot on safe surface

  • Session Frequency: 3–5 sessions/week

  • Duration: 8–12 weeks (then ongoing)

  • Cautions & Safety Notes: Stop if dizziness or chest pain occurs. Modify or skip deep knee bends during joint flares. Use stable support if fall risk is present. Post-surgery or significant heart/lung disease requires clinician clearance.


9. Chiropractic Care 🔗 (view details)

  • Function: Chiropractic care adjustments realign the spine, alleviate pain, and improve musculoskeletal function, supporting overall health.

  • Safe & Effective Use: Assessment and spinal adjustments by a qualified chiropractor

  • Session Frequency: 1–2 sessions/week

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Skip manipulation over fractures, spinal instability, or immediately after spine surgery. Use gentle methods for severe osteoporosis. Avoid high-velocity neck techniques with known carotid/vertebral artery disease or recent stroke/TIA. Stop if pain sharply worsens or if new numbness, weakness, or bladder/bowel changes appear. Use added caution when on blood thinners.


10. Hydrotherapy 🔗 (view details)

  • Function: Hydrotherapy through warm water immersion soothes muscles, reduces tension, and alleviates pain, promoting relaxation and comfort.

  • Safe & Effective Use: Warm soak or bath: 10–20 min; gentle range-of-motion in water; Contrast shower: warm 2–3 min → cool 30–60 sec; repeat 3–5 cycles; finish cool; Warm compress to painful area: 10–15 min; refresh as needed

  • Session Frequency: 3–5 sessions/week

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Test temperature to avoid burns or cold injury; reduced sensation or cardiovascular disease—use clinician guidance; stop if dizziness, chest pain, shortness of breath, or worsening symptoms.


11. Hypnotherapy 🔗 (view details)

  • Function: Hypnotherapy uses deep focus and relaxation techniques to help manage pain, offering a natural, non-pharmacological method for improved mental and physical health.

  • Safe & Effective Use: Certified hypnotherapist; guided relaxation and imagery; optional home audio; 30–60 min/session

  • Session Frequency: 1–2 sessions/week

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Not a substitute for medical care; continue prescribed treatments; do not use hypnosis to “recover” memories; stop if distress or symptom worsening occurs.


12. Biofeedback 🔗 (view details)

  • Function: Biofeedback teaches individuals how to control physiological responses, providing a powerful self-management tool for pain relief.

  • Safe & Effective Use: Sessions with trained clinician using biofeedback device; home practice as instructed

  • Session Frequency: 1–2 sessions/week + 10–20 min home practice most days (consistency is key)

  • Duration: 4–8 weeks

  • Cautions & Safety Notes: Noninvasive technique. Stop and rest if you feel lightheaded or overbreathing symptoms. People with serious heart rhythm conditions, uncontrolled seizures, or recent stroke should work under clinician supervision.

Global Safety Note

ℹ️ Guidance Note
Not a protocol—each supplement is listed individually with references; anecdotes are flagged
 

Introduce gradually
 

  • Start with one supplement

  • Add one new supplement every 3–7 days if tolerated

  • Keep ≤3 changes at once
     

Stacking rules
 

  • Don’t combine supplements with the same primary Effect

  • Use only listed synergies; avoid antagonisms or separate by the stated time

  • Track total exposure when items share an active or pathway (e.g., melatonin, zinc)


Use Window
 

  • Respect each item’s Timing and Duration caps

  • Stop early once goals are met; re-evaluate at 8–12 weeks

  • See Global Safety Note below

ℹ️ Guidance Note
Not a protocol—each natural compound is listed individually with references; anecdotes are flagged
 

Introduce gradually
 

  • Start with one natural compound

  • Add one new compound every 3–7 days if tolerated

  • Keep ≤2 changes at once
     

Stacking rules
 

  • Don’t combine compounds with the same primary Effect

  • Use only listed synergies; avoid antagonisms or separate by the stated time

  • Track total exposure when compounds share an active or pathway (e.g., organic acids like ACV, alkalizers like sodium bicarbonate, metal ions like colloidal silver)


Use Window
 

  • Respect each item’s Timing and Duration caps

  • Always patch-test topical applications

  • Do not layer potential irritants on the same area

  • Stop at first signs of irritation or intolerance

  • See Global Safety Note below

Already a Subscriber? Log In

See a fully unlocked page

Already a Subscriber? Log In

See a fully unlocked page

Direct / Indirect Support 

(Most Helpful → Least Helpful)

Direct / Indirect Support 

(Most Helpful → Least Helpful)

Already a Subscriber? Log In

See a fully unlocked page

Already a Subscriber? Log In

See a fully unlocked page

Functional Lab Tests You May Wish to Explore

Currently, no functional lab tests aligned with our integrative and natural health standards are available for this condition. Once reliable tests are identified and validated, we will review and feature them here.

Already a Subscriber? Log In

See a fully unlocked page

Books Worth Considering for Deeper Insight

Back Mechanic

Chronically Painful

Fixing You: Hip & Knee Pain

Fixing You: Shoulder & Elbow Pain

Foundations of Health

Heal Your Pain Now

Healthy Joints for Life in Just 8 Weeks

Holistic Pain Relief

Living Beyond Pain

Living a Healthy Life with Chronic Conditions

Maximum Pain Relief with Your TENS Unit

No Grain, No Pain

Outsmart Your Pain

Pain Free

Pain Is Not What It Seems

Currently, no high-quality books meeting our functional, integrative, and natural healing standards are available for this condition. As soon as trusted resources are published, we will review and feature them here.

Already a Subscriber? Log In

See a fully unlocked page

Podcasts That Offer Valuable Perspectives

Currently, no high-quality podcast episodes meeting our functional, integrative, and natural healing standards are available for this condition. We will review and feature trusted resources here as soon as they become available.

A Menu of Strategies for Chronic Pain

Chronic Pain and How to Combat It

Chronic Pain and Neurological Rewiring

Control Pain and Heal Faster With Your Brain

Everything You Know About Back Pain Is Wrong

Got Pain?: Use Your Lymphatic System to Fix It

Managing Chronic Pain: Coping Tips for Relief

Medical Marijuana

Relieve Chronic Pain

Already a Subscriber? Log In

See a fully unlocked page

Using Cannabis for Symptom Management

Educational Videos To Learn From

Currently, no high-quality podcast episodes meeting our functional, integrative, and natural healing standards are available for this condition. We will review and feature trusted resources here as soon as they become available.

Already a Subscriber? Log In

See a fully unlocked page

How Key Nutrients Support the Body

Fatty Acids: Fatty acids serve as energy sources, structural components of cell membranes, and precursors to signaling molecules. Essential fatty acids, like omega-3 and omega-6, play critical roles in brain function, cardiovascular health, and inflammation regulation.


Herbal Extracts: Herbal extracts contain bioactive compounds with various medicinal properties, including antioxidant, anti-inflammatory, and antimicrobial effects. They have been used traditionally to support digestion, immunity, and overall health.


Minerals: Minerals are essential for various physiological functions, including bone health, nerve transmission, and enzyme activity. They support overall health by ensuring proper cellular function and metabolic processes.


Vitamins: Vitamins are essential micronutrients that play diverse roles in supporting cellular processes, immune function, and overall health. They must be obtained through diet or supplementation to ensure proper bodily function.

References

[1] Helde-Frankling M, Björkhem-Bergman L. Vitamin D in Pain Management. Int J Mol Sci. 2017;18(10):2170.
[2] Riehemann K, Behnke B, Schulze-Osthoff K. Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-kappaB. FEBS Lett. 1999;442(1):89-94.
[3] Jacquet A, Girodet PO, Pariente A, Forest K, Mallet L, Moore N. Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. Arthritis Res Ther. 2009;11(6):R192.
[4] Johnson TA, Sohn J, Inman WD, Bjeldanes LF, Rayburn K. Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders. Phytomedicine. 2013;20(2):143-147.
[5] Obertreis B, Ruttkowski T, Teucher T, Behnke B, Schmitz H. Ex-vivo in-vitro inhibition of lipopolysaccharide stimulated tumor necrosis factor-alpha and interleukin-1 beta secretion in human whole blood by extractum urticae dioicae foliorum [published correction appears in Arzneimittelforschung 1996 Sep;46(9):936]. Arzneimittelforschung. 1996;46(4):389-394.
[6] Kragstrup TW. Vitamin D supplementation for patients with chronic pain. Scand J Prim Health Care. 2011;29(1):4-5.
[7] Shipton EE, Shipton EA. Vitamin D Deficiency and Pain: Clinical Evidence of Low Levels of Vitamin D and Supplementation in Chronic Pain States. Pain Ther. 2015, Vol 4, pp 67–87.
[8] Sánchez-Ramírez GM, Caram-Salas NL, Rocha-González HI, et al. Benfotiamine relieves inflammatory and neuropathic pain in rats. Eur J Pharmacol. 2006;530(1-2):48-53.
[9] Winkler G, Pál B, Nagybéganyi E, Ory I, Porochnavec M, Kempler P. Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy. Arzneimittelforschung. 1999;49(3):220-224.
[10] Balakumar P1, Rohilla A, Krishan P, Solairaj P, Thangathirupathi A. The Multifaceted Therapeutic Potential Of Benfotiamine. Pharmacol Res. 2010 Jun;61(6):482-8.
[11] Woelk H, Lehrl S, Bitsch R, Koepcke W. Benfotiamine in treatment of alcoholic polyneuropathy: an 8-week randomized controlled study (BAP I Study). Alcohol and alcoholism. 1998, 33 6, 631 8.
[12] DSM Pharma Solutions Editors. Back to Basics: The Impact of B-Vitamins on Low Back Pain. DSM. 2018, Apr.
[13] Montiel-Ruiz R, et al. Synergistic Interaction of Diclofenac, Benfotiamine, and Resveratrol in Experimental Acute Pain. Drug Development Research. 2011, vol 72. pp 397 - 404.
[14] Randall CF. Treatment of musculoskeletal pain with the sting of the stinging nettle: Urtica dioica.
University of Plymouth. 2001, Apr.
[15] Hajhashemi V, Klooshani V. Antinociceptive and anti-inflammatory effects of Urtica dioica leaf extract in animal models. Avicenna J Phytomed. 2013;3(2):193-200.
[16] Liao JC, et al. Evaluation of a root extract gel from Urtica dioica (Urticaceae) as analgesic and anti-inflammatory therapy in rheumatoid arthritis in mice. Tropical Journal of Pharmaceutical Research. 2016, Vol 15, Issue 4.
[17] Committee on Herbal Medicinal Products. Assessment report on Urtica dioica L., Urtica urens L., folium. European Medicines Agency. 2010, Jan.
[18] Prego-Dominguez J, Hadrya F, Takkouche B. Polyunsaturated fatty acids and chronic pain: a systematic review and meta-analysis. Pain physician. 2016;19(8):521.
[19] Unda SR, Villegas EA, Toledo ME, Asis Onell G, Laino CH. Beneficial effects of fish oil enriched in omega-3 fatty acids on the development and maintenance of neuropathic pain. Journal of Pharmacy and Pharmacology. 2020 Mar;72(3):437-47.
[20] Cortes ML, Castro MM, Jesus RP, Barros Neto JA, Kraychete DC. Therapy with omega-3 fatty acids for patients with chronic pain and anxious and depressive symptoms. Revista Dor. 2013;14:48-51.
[21] Hasriadi, Dasuni Wasana PW, Vajragupta O, Rojsitthisak P, Towiwat P. Mechanistic insight into the effects of curcumin on neuroinflammation-driven chronic pain. Pharmaceuticals. 2021 Aug 7;14(8):777.
[22] Sun J, Chen F, Braun C, Zhou YQ, Rittner H, Tian YK, Cai XY, Ye DW. Role of curcumin in the management of pathological pain. Phytomedicine. 2018 Sep 15;48:129-40.
[23] Jeon Y, Kim CE, Jung D, Kwak K, Park S, Lim D, Kim S, Baek W. Curcumin could prevent the development of chronic neuropathic pain in rats with peripheral nerve injury. Current Therapeutic Research. 2013 Jun 1;74:1-4.
[24] Urits I, Jung JW, Amgalan A, Fortier L, Anya A, Wesp B, Orhurhu V, Cornett EM, Kaye AD, Imani F, Varrassi G. Utilization of magnesium for the treatment of chronic pain. Anesthesiology and Pain Medicine. 2021 Feb;11(1).
[25] Tarleton EK, Kennedy AG, Rose GL, Littenberg B. Relationship between magnesium intake and chronic pain in US adults. Nutrients. 2020 Jul 16;12(7):2104.
[26] Yu G, Xiang W, Zhang T, Zeng L, Yang K, Li J. Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC complementary medicine and therapies. 2020 Dec;20(1):1-6.
[27] Lampl C, Haider B, Schweiger C. Long-term efficacy of Boswellia serrata in four patients with chronic cluster headache. Cephalalgia. 2012 Jul;32(9):719-22.
[28] Chrubasik S. Devil’s claw extract as an example of the effectiveness of herbal analgesics. Der Orthopäde. 2004 Jul;33:804-8.
[29] Chamberland G. Chronic Pain Management: Use of a Devil’s claw agent to inhibit cytokine release.
[30] Shara M, Stohs SJ. Efficacy and safety of white willow bark (Salix alba) extracts. Phytotherapy Research. 2015 Aug;29(8):1112-6.
[31] Saller R, Melzer J, Felder M. Pain relief with a proprietary extract of Willow bark in rheumatology. An Open Trial. Schweizerische Zeitschrift für Ganzheitsmedizin/Swiss Journal of Integrative Medicine. 2008;20(3):156-62.
[32] Villanueva MR, Joshaghani N, Villa N, Badla O, Goit R, Saddik SE, Dawood SN, Rabih AM, Niaj A, Raman A, Uprety M. Efficacy, safety, and regulation of cannabidiol on chronic pain: a systematic review. Cureus. 2022 Jul 16;14(7).
[33] Henson JD, Vitetta L, Hall S. Tetrahydrocannabinol and cannabidiol medicines for chronic pain and mental health conditions. Inflammopharmacology. 2022 Aug;30(4):1167-78.
[34] Boehnke KF, Gagnier JJ, Matallana L, Williams DA. Substituting cannabidiol for opioids and pain medications among individuals with fibromyalgia: a large online survey. The journal of pain. 2021 Nov 1;22(11):1418-28.
[35] Vickers AJ, Cronin AM, Maschino AC, Lewith G, MacPherson H, Foster NE, Sherman KJ, Witt CM, Linde K, Acupuncture Trialists' Collaboration FT. Acupuncture for chronic pain: individual patient data meta-analysis. Archives of internal medicine. 2012 Oct 22;172(19):1444-53.
[36] Vickers AJ, Vertosick EA, Lewith G, MacPherson H, Foster NE, Sherman KJ, Irnich D, Witt CM, Linde K, Acupuncture Trialists' Collaboration. Acupuncture for chronic pain: update of an individual patient data meta-analysis. The Journal of Pain. 2018 May 1;19(5):455-74.
[37] Vickers AJ, Linde K. Acupuncture for chronic pain. Jama. 2014 Mar 5;311(9):955-6.
[38] Jensen MP, Gertz KJ, Kupper AE, Braden AL, Howe JD, Hakimian S, Sherlin LH. Steps toward developing an EEG biofeedback treatment for chronic pain. Applied psychophysiology and biofeedback. 2013 Jun;38:101-8.
[39] Sielski R, Rief W, Glombiewski JA. Efficacy of biofeedback in chronic back pain: a meta-analysis. International journal of behavioral medicine. 2017 Feb;24:25-41.
[40] Urits I, Schwartz RH, Orhurhu V, Maganty NV, Reilly BT, Patel PM, Wie C, Kaye AD, Mancuso KF, Kaye AJ, Viswanath O. A comprehensive review of alternative therapies for the management of chronic pain patients: acupuncture, tai chi, osteopathic manipulative medicine, and chiropractic care. Advances in therapy. 2021 Jan;38:76-89.
[41] Herman PM, Kommareddi M, Sorbero ME, Rutter CM, Hays RD, Hilton LG, Ryan GW, Coulter ID. Characteristics of chiropractic patients being treated for chronic low back and neck pain. Journal of manipulative and physiological therapeutics. 2018 Jul 1;41(6):445-55.
[42] Haavik H, Niazi IK, Holt K, Murphy B. Effects of 12 weeks of chiropractic care on central integration of dual somatosensory input in chronic pain patients: a preliminary study. Journal of manipulative and physiological therapeutics. 2017 Mar 1;40(3):127-38.
[43] Tsao JC. Effectiveness of massage therapy for chronic, non-malignant pain: a review. Evidence-based complementary and alternative medicine. 2007 Jun 1;4(2):165-79.
[44] Walach H, Güthlin C, König M. Efficacy of massage therapy in chronic pain: a pragmatic randomized trial. The Journal of Alternative & Complementary Medicine. 2003 Dec 1;9(6):837-46.
[45] Tul Y, Unruh A, Dick BD. Yoga for chronic pain management: a qualitative exploration. Scandinavian journal of caring sciences. 2011 Sep;25(3):435-43.
[46] Chang DG, Holt JA, Sklar M, Groessl EJ. Yoga as a treatment for chronic low back pain: A systematic review of the literature. Journal of orthopedics & rheumatology. 2016 Jan 1;3(1):1.
[47] Peng PW. Tai chi and chronic pain. Regional Anesthesia & Pain Medicine. 2012 Jul 1;37(4):372-82.
[48] Kong LJ, Lauche R, Klose P, Bu JH, Yang XC, Guo CQ, Dobos G, Cheng YW. Tai Chi for chronic pain conditions: a systematic review and meta-analysis of randomized controlled trials. Scientific reports. 2016 Apr 29;6(1):25325.
[49] Taylor DA, Genkov KA. Hypnotherapy for the treatment of persistent pain: a literature review. Journal of the American Psychiatric Nurses Association. 2020 Mar;26(2):157-61.
[50] Roja Z, Kalkis V, Roja I, Kalkis H. The effects of a medical hypnotherapy on clothing industry employees suffering from chronic pain. Journal of Occupational Medicine and Toxicology. 2013 Dec;8(1):1-5.
[51] Kuchera ML. Applying osteopathic principles to formulate treatment for patients with chronic pain. Journal of Osteopathic Medicine. 2007 Nov 1;107(s6):E28-38.
[52] Rehman Y, Ferguson H, Bozek A, Blair J, Allison A, Johnston R. Osteopathic manual treatment for pain severity, functional improvement, and return to work in patients with chronic pain. Journal of Osteopathic Medicine. 2020 Dec 1;120(12):888-906.
[53] Rowen RJ, Robins H. Ozone therapy for complex regional pain syndrome: review and case report. Current pain and headache reports. 2019 Jun;23:1-5.
[54] Alsawy TT, Sabry LS, Elmulla AF, Kamel MA, Eldemrdash AM, Hashem EY. Efficacy of Medical Ozone for Treatment of Chronic Musculoskeletal Pain with Abnormal Mitochondrial Redox State.
[55] Kiralp MZ, Yildiz Ş, Vural D, Keskin I, Ay H, Dursun H. Effectiveness of hyperbaric oxygen therapy in the treatment of complex regional pain syndrome. Journal of international medical research. 2004 May;32(3):258-62.
[56] Schiavo S, DeBacker J, Djaiani C, Bhatia A, Englesakis M, Katznelson R. Mechanistic rationale and clinical efficacy of hyperbaric oxygen therapy in chronic neuropathic pain: an evidence-based narrative review. Pain Research and Management. 2021 Apr 22;2021.
[57] Johnson MI, Paley CA, Jones G, Mulvey MR, Wittkopf PG. Efficacy and safety of transcutaneous electrical nerve stimulation (TENS) for acute and chronic pain in adults: A systematic review and meta-analysis of 381 studies (the meta-TENS study). BMJ open. 2022 Feb 1;12(2):e051073.
[58] Paley CA, Wittkopf PG, Jones G, Johnson MI. Does TENS reduce the intensity of acute and chronic pain? A comprehensive appraisal of the characteristics and outcomes of 169 reviews and 49 meta-analyses. Medicina. 2021 Oct 4;57(10):1060.
[59] Mao S, Xiao K, Zhou W, Xu H, Zhang S. The impact of hot spring hydrotherapy on pain perception and dysfunction severity in patients with chronic low back pain: a systematic review and meta-analysis. Journal of Pain Research. 2023 Dec 31:3925-44.
[60] Christakou A, Boulnta F. The effectiveness of hydrotherapy in patients with chronic low back pain. Physiotherapy Quarterly. 2020 Jun 1;28(3):32-8.
[61] Battisti E, Albanese A, Guerra L, Argnani L, Giordano N. Alpha lipoic acid and superoxide dismutase in the treatment of chronic low back pain. Eur J Phys Rehabil Med. 2013 Oct 1;49(5):659-4.
[62] Rodrigues P, Cassanego GB, Peres DS, Viero FT, Kudsi SQ, Ruviaro NA, de Vargas Aires K, Portela VM, Bauermann LD, Trevisan G. Alpha-lipoic acid reduces nociception by reducing oxidative stress and neuroinflammation in a model of complex regional pain syndrome type I in mice. Behavioural Brain Research. 2024 Feb 29;459:114790.
[63] Jacobsen S, Danneskiold-Samsøe B, Andersen RB. Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation. Scandinavian journal of rheumatology. 1991 Jan 1;20(4):294-302.
[64] Di Padova C. S-adenosylmethionine in the treatment of osteoarthritis: review of the clinical studies. The American journal of medicine. 1987 Nov 20;83(5):60-5.
[65] Sawaddiruk P, Apaijai N, Paiboonworachat S, Kaewchur T, Kasitanon N, Jaiwongkam T, Kerdphoo S, Chattipakorn N, Chattipakorn SC. Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction. Free radical research. 2019 Aug 3;53(8):901-9.
[66] Lee J, Hong YS, Jeong JH, Yang EJ, Jhun JY, Park MK, Jung YO, Min JK, Kim HY, Park SH, Cho ML. Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines. PLoS One. 2013 Jul 22;8(7):e69362.
[67] Rondanelli M, Fossari F, Vecchio V, Gasparri C, Peroni G, Spadaccini D, Riva A, Petrangolini G, Iannello G, Nichetti M, Infantino V. Clinical trials on pain lowering effect of ginger: A narrative review. Phytotherapy Research. 2020 Nov;34(11):2843-56.
[68] Rondanelli M, Riva A, Morazzoni P, Allegrini P, Faliva MA, Naso M, Miccono A, Peroni G, Degli Agosti I, Perna S. The effect and safety of highly standardized Ginger (Zingiber officinale) and Echinacea (Echinacea angustifolia) extract supplementation on inflammation and chronic pain in NSAIDs poor responders. A pilot study in subjects with knee arthrosis. Natural product research. 2017 Jun 3;31(11):1309-13.
[69] Sankar L. Effectiveness of Epsom salt with hot water application on knee joint pain among elderly in a selected rural area at Puducherry. Pondicherry Journal of Nursing (PJN). 2019;12(2):42-5p.
[70] Damor DC, Pujari J, Mansuri MU, Rawat VS. A Comparative Study to Assess the Effectiveness of Epsom Salt with Hot Water Versus Plain Water on Pain and Functional Performance Among Arthritis Patients at Selected Hospital, Udaipur.

Already a Subscriber? Log In

See a fully unlocked page

Medical Disclaimer

The information provided above is for general educational purposes and is intended to support individuals seeking to better understand natural options for managing specific health concerns. It includes guidance on supplements, plant extracts, natural compounds, and alternative therapies.
 

This content is not intended to diagnose, treat, cure, or prevent any disease and should not be used as a substitute for personalized medical advice. Individual needs may vary based on diagnosis, medication use, or underlying health conditions.
 

Always consult a qualified healthcare practitioner before starting any new supplement, remedy, or therapeutic approach—especially if you have a medical condition, take prescription medications, or are pregnant or breastfeeding.
 

Use of any protocols or products discussed is at the sole discretion and risk of the individual.

bottom of page